Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Autor: K. George Chandy, Karoline Sanches, Raymond S. Norton

Publikováno v: Channels, Vol 17, Iss 1 (2023)

ABSTRACTThe voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivati

Externí odkaz: https://doaj.org/article/80bfe485ae704710846065fcf1a10db8

Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Autor: Karoline Sanches, Raphael Vinicius Rodrigues Dias, Paulo Henrique da Silva, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fátima Pereira de Souza, Leandro Cristante de Oliveira, Fernando Alves de Melo

Publikováno v: Heliyon, Vol 5, Iss 11, Pp e02869- (2019)

Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome.

Externí odkaz: https://doaj.org/article/2e8b13c322784fc9aaea4b6a5af4bfb2

Dynamics of the SARS-CoV-2 nucleoprotein N-terminal domain triggers RNA duplex destabilization

Autor: Anderson S. Pinheiro, Karoline Sanches, Andrea T. Da Poian, Fabio C. L. Almeida, Ícaro Putinhon Caruso

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biophysical Journal

Made available in DSpace on 2022-04-29T08:30:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-20 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) The nucleocapsid (N) protein of betacoronaviruses is responsible for nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63d4b81367f15662fe2b17a1e598dc1
https://doi.org/10.1016/j.bpj.2021.06.003

The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions

Autor: Karoline Sanches, Fabio C. L. Almeida, Fernando A. Melo, Ícaro Putinhon Caruso

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scientific Reports

Made available in DSpace on 2020-12-12T01:33:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01 Universidade Estadual Paulista Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e3873ca46613eee52fd5db1a5dcd0b
http://link.springer.com/article/10.1038/s41598-020-70034-w

Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA

Autor: Thais Cristtina Neves-Martins, Aline de Luna Marques, Gabriela R. Araujo, Mariana J. do Amaral, Isabella Otenio de Lourenço, Vitor S. Almeida, Ícaro Putinhon Caruso, Francisco Gomes-Neto, Guilherme Caldas Andrade, Andrea T. Da Poian, Talita S. Araujo, Glauce M. Barbosa, Karoline Sanches, Ariana A. Vasconcelos, Clara L. F. Malizia-Motta, Katia M. S. Cabral, Peter Reis Bezerra, Marcos Caique Santana-Silva, Nathane C. Mebus-Antunes, Jessica M. Azevedo, Cristiane D. Anobom, Leonardo Bartkevihi, Gisele Cardoso Amorim, Fabio C. L. Almeida, Jessica M. Sa, Anderson S. Pinheiro, Marcius S. Almeida

The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding protein, which plays a major role in nucleocapsid assembly and discontinuous RNA transcription, facilitating the template switch of transcriptional regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba4092d34b6208964bdc927921ac0ff
https://doi.org/10.1101/2021.07.21.453232