Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karoline E. Kokot"'
Autor:
Jes-Niels Boeckel, Maximilian Möbius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, Laura Schoppe, Rewati Tappu, Karoline E. Kokot, Jasmin M. Kneuer, Susanne Gaul, Diana M. Bordalo, Alan Lai, Jan Haas, Mahsa Ghanbari, Philipp Drewe-Boss, Martin Liss, Hugo A. Katus, Uwe Ohler, Michael Gotthardt, Ulrich Laufs, Katrin Streckfuss-Bömeke, Benjamin Meder
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 129-146 (2022)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Externí odkaz:
https://doaj.org/article/1a62d499b1c84c03a1e970a9381d3d3a
Autor:
Karoline E. Kokot, Jasmin M. Kneuer, David John, Sabine Rebs, Maximilian N. Möbius-Winkler, Stephan Erbe, Marion Müller, Michael Andritschke, Susanne Gaul, Bilal N. Sheikh, Jan Haas, Holger Thiele, Oliver J. Müller, Susanne Hille, Florian Leuschner, Stefanie Dimmeler, Katrin Streckfuss-Bömeke, Benjamin Meder, Ulrich Laufs, Jes-Niels Boeckel
Publikováno v:
Basic Res. Cardiol. 117:32 (2022)
Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA editing in failing human hearts. Transcriptome sequencing showed that adenosine-to-inosine (A-to-I) RNA editing was responsible
Publikováno v:
European Heart Journal. 42
Background and purpose Trimethylamine N-oxide (TMAO) is associated with a higher risk of atherosclerotic diseases. However, the underlying molecular mechanisms are not completely understood. Inflammation and following endothelial-to-mesenchymal trans
Autor:
Benjamin Meder, Holger Thiele, M Andritschke, M. Mueller, S Dimmeler, David John, J.-N Boeckel, Ulrich Laufs, Florian Leuschner, Karoline E. Kokot, Jan Haas, M Moebius-Winkler, S Gaul, B Sheikh, J Kneuer
Publikováno v:
European Heart Journal. 42
Background and purpose Post-transcriptional RNA editing is an important mechanism in the development of human diseases. RNA editing can affect RNA stability and alternative splicing. The aim of our study was to characterize RNA editing and its impact
Autor:
Michael Gotthardt, Jes-Niels Boeckel, Mahsa Ghanbari, Maximilian Möbius-Winkler, Martin Liss, Jasmin M Kneuer, Uwe Ohler, Philipp Drewe-Boss, Sabine Rebs, Alan Lai, Katrin Streckfuss-Bömeke, Nicole Eger, Karoline E. Kokot, Laura Schoppe, Rewati Tappu, Jan Haas, Ulrich Laufs, Diana Martins Bordalo, Susanne Gaul, Marion Müller, Hugo A. Katus, Benjamin Meder
Publikováno v:
Genomics, proteomicsbioinformatics. 20(1)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Autor:
Reinier A. Boon, Jes-Niels Boeckel, David John, Marion Muhly-Reinholz, David Hassel, Patrick Hofmann, Hanjoong Jo, Ariane Fischer, Wesley Abplanalp, Andreas W. Heumüller, Simone F. Glaser, Stefan Günther, Lukas Tombor, Karoline E. Kokot, Stefanie Dimmeler, Sandeep Kumar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(8), 4180-4187. National Academy of Sciences
Glaser, S F, Heumüller, A W, Tombor, L, Hofmann, P, Muhly-Reinholz, M, Fischer, A, Günther, S, Kokot, K E, Hassel, D, Kumar, S, Jo, H, Boon, R A, Abplanalp, W, John, D, Boeckel, J-N & Dimmeler, S 2020, ' The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4180-4187 . https://doi.org/10.1073/pnas.1913481117
Proceedings of the National Academy of Sciences of the United States of America
Glaser, S F, Heumüller, A W, Tombor, L, Hofmann, P, Muhly-Reinholz, M, Fischer, A, Günther, S, Kokot, K E, Hassel, D, Kumar, S, Jo, H, Boon, R A, Abplanalp, W, John, D, Boeckel, J-N & Dimmeler, S 2020, ' The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4180-4187 . https://doi.org/10.1073/pnas.1913481117
Proceedings of the National Academy of Sciences of the United States of America
Significance Here we show that the histone demethylase JMJD2B is induced in endothelial cells by EndMT provoking stimuli and thereby contributes to the acquirement of a mesenchymal/smooth muscle phenotype. Silencing of JMJD2B inhibited EndMT in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754136becad93a43f1599c36463daa9a
https://research.vumc.nl/en/publications/3a5938db-c0be-4c0d-a8bd-2e99765ba490
https://research.vumc.nl/en/publications/3a5938db-c0be-4c0d-a8bd-2e99765ba490
Autor:
Ariane Fischer, Jes Niels Boeckel, Simone F. Glaser, Lukas Tombor, Hanjoong Jo, Hitoshi Okada, Marion Muhly-Reinholz, Reinier A. Boon, David Hassel, David John, Sandeep Kumar, Patrick Hofmann, Karoline E. Kokot, Stefanie Dimmeler, Andreas W. Heumüller, Stefan Günther, Wesley Abplanalp
Publikováno v:
Proceedings of the National Academy of Sciences. 117:8657-8657
Endothelial cells play an important role in maintenance of the vascular system and the repair after injury. Under proinflammatory conditions, endothelial cells can acquire a mesenchymal phenotype by a process named endothelial-to-mesenchymal transiti
Autor:
Karoline E. Kokot, Stefanie Dimmeler, Wei Chen, Jan Haas, Timon Seeger, Hugo A. Katus, Jes-Niels Boeckel, Benjamin Meder, David John, Niels Grabe, Elham Kayvanpour, Andreas M. Zeiher, Stephan von Haehling, Simone F. Glaser, Andreas W. Heumüller, Nicole Ebner, Florian Leuschner, Till Keller, Maximilian K. Lackner, Maya F. Perret, Stephan Fichtlscherer, Sabine Hünecke, Christoph Dieterich
Publikováno v:
Journal of molecular and cellular cardiology. 126
Aims Circulating immune cells have a significant impact on progression and outcome of heart failure. Long non-coding RNAs (lncRNAs) comprise novel epigenetic regulators which control cardiovascular diseases and inflammatory disorders. We aimed to ide