Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karoline A. Hosiawa"'
Autor:
Jonathan M. Clingan, Kristin M. Ostrow, Karoline A. Hosiawa, Mehrdad Matloubian, Zhijian J. Chen
Publikováno v:
The Journal of Immunology. 188:4432-4440
The necessity for pathogen recognition of viral infection by the innate immune system in initiating early innate and adaptive host defenses is well documented. However, little is known about the role these receptors play in the maintenance of adaptiv
Autor:
Scott N. Mueller, Karoline A. Hosiawa-Meagher, Rafi Ahmed, Martin F. Bachmann, Bogumila T. Konieczny, Mehrdad Matloubian, Brandon M. Sullivan, Richard M. Locksley
Publikováno v:
Science. 317:670-674
The chemokines CCL21 and CXCL13 are immune factors that dictate homing and motility of lymphocytes and dendritic cells in lymphoid tissues. However, the means by which these chemokines are regulated and how they influence cell trafficking during immu
Publikováno v:
Transplantation Reviews. 19:213-220
The current overwhelming unmet demand for donor organs warrants the search for alternative sources. Pig-to-human xenotransplantation represents a promising approach; however, before this solution can be realized, there are many immunological hurdles
Autor:
Erling W. Rud, Luoling Xu, Steven E. Bosinger, Jocelyn Fournier, Longsi Ran, Monique Parenteau, Karoline A. Hosiawa, Mark J. Cameron, Mohamed R. Boulassel, David J. Kelvin, Desmond Persad
Publikováno v:
The Journal of Immunology. 173:6858-6863
HIV infection is characterized by a host response composed of adaptive and innate immunity that partially limits viral replication; however, it ultimately fails in eradicating the virus. To model host gene expression during acute HIV infection, we in
Autor:
Hao Wang, Bertha Garcia, Xiaoxia Zhang, Robert Zhong, Dejun Zhou, Thomas E. Ichim, Karoline A. Hosiawa, Jinming Yang, Dameng Lian, David J. Kelvin, Wei-Ping Min
Publikováno v:
The Journal of Immunology. 171:3823-3836
We determined the role of cytokines in regulating the pattern of rejection and recipient susceptibility to cyclosporine (CsA) in a mouse cardiac allograft model. Hearts from C3H mice transplanted into untreated BALB/c (Th2-dominant) and C57BL/6 (Th1-
Autor:
Hao Wang, Karoline A. Hosiawa, Bertha Garcia, Robert Zhong, Jeffrey Shum, Patrick Dutartre, David J. Kelvin
Publikováno v:
Xenotransplantation. 10:325-336
Searching for a novel immunosuppressive agent to effectively prevent acute vascular rejection (AVR) is essential for success in clinical xenotransplantation. We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical
Autor:
Patrick Dutartre, Karoline A. Hosiawa, David J. Kelvin, Jeffrey Shum, Bertha Garcia, Hao Wang, Robert Zhong
Publikováno v:
Transplantation. 75:1475-1481
Background. We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in
Autor:
Hao Wang, Jifu Jiang, Mark E. DeVries, Karoline A. Hosiawa, Robert Zhong, Bertha Garcia, Dejun Zhou, Mark J. Cameron, David J. Kelvin
Publikováno v:
Transplantation. 81(2)
Background. Xenotransplantation may provide a solution to the increasing shortage of donor organs. Acute vascular rejection and cell-mediated rejection remain the primary barriers to successful xenotransplantation. In animal models where acute vascul
Autor:
Ali Akram, Karoline A. Hosiawa, Hongtao Sun, David J. Kelvin, Mark J. Cameron, Hao Wang, Dejun Zhou, Bertha Garcia, Weihua Liu, Robert Zhong, Jifu Jiang, Mark E. DeVries
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(9)
Xenotransplantation may provide the only solution to the shortage of human donor organs. Although hyperacute rejection associated with xenotransplantation can now be overcome, acute vascular rejection (AVR) remains a primary barrier to xenotransplant
Autor:
Cheryl M. Cameron, Atsuo Ochi, David J. Kelvin, Takashi Uchiyama, Sebastian A. Mikolajczak, Bruce Y. Ma, Karoline A. Hosiawa, Akifumi Takaori-Kondo, Ali Danesh
Publikováno v:
Blood. 106(6)
OX40 and 4-1BB are members of the tumor necrosis factor (TNF) family of costimulatory receptors whose signaling is important for differential immune responses mediated by CD4+ or CD8+ T cells. Although activated T cells may acquire OX40/4-1BB double-