Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karolina Windloch"'
Autor:
Eva Baxter, Fares Al-Ejeh, Mariska Miranda, Jason Sang Hun Lee, Greg Kelly, Francesco Casciello, Frank Gannon, Karolina Windloch
Publikováno v:
Theranostics
Rationale: Epigenetic mechanisms are fundamental processes that can modulate gene expression, allowing cellular adaptation to environmental conditions. Hypoxia is an important factor known to initiate the metastatic cascade in cancer, activating cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ea8d902468864ff90269ff18bf049f
https://doi.org/10.7150/thno.41453
https://doi.org/10.7150/thno.41453
Autor:
Karolina Windloch, Frank Gannon, Donal J. Brennan, Jason Sang Hun Lee, Greg Kelly, Eva Baxter
Publikováno v:
Endocrine-Related Cancer. 26:31-46
Up to 80% of endometrial and breast cancers express oestrogen receptor alpha (ERα). Unlike breast cancer, anti-oestrogen therapy has had limited success in endometrial cancer, raising the possibility that oestrogen has different effects in both canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4987bf045480389d526bdd0e8d343d4c
https://doi.org/10.1530/erc-17-0563
https://doi.org/10.1530/erc-17-0563
Autor:
Karolina Windloch
Publikováno v:
EMJ Rheumatology. :2-10
Prof Fernando Perez-Ruiz opened the symposium, which focussed on the current unmet need in controlling gout and associated comorbidities with current standard of care. Prof Till Uhlig reviewed the epidemiology and pathogenesis of the disease and Prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e42b203e7cf203e2a22ff91249cd0e7
https://doi.org/10.33590/emjrheumatol/10313098
https://doi.org/10.33590/emjrheumatol/10313098
Autor:
Greg Kelly, Jason Sang Hun Lee, Michelle M. Hill, Fares Al-Ejeh, Thomas Stoll, Arabella Young, Mark J. Smyth, Frank Gannon, Donal J. Brennan, Francesco Casciello, Shin Foong Ngiow, Karolina Windloch
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7077-7082
G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595ecd1c3b73b4504c19f69bdc0facd7
https://doi.org/10.1073/pnas.1618706114
https://doi.org/10.1073/pnas.1618706114
Autor:
Karolina Windloch, Matilda Lindgren, Chen Tian, Lynn Dorothy Poulton, Beau Corazon, Teresa Domagala, David Mabon, Jonathan Kannan Nambiar, Adam Clarke, Matthew Pollard, Chris Buhmann, Anthony Gerard Doyle, Doris Shim
Publikováno v:
mAbs
CD1d is a receptor on antigen-presenting cells involved in triggering cell populations, particularly natural killer T (NKT) cells, to release high levels of cytokines. NKT cells are implicated in asthma pathology and blockade of the CD1d/NKT cell pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db30e08f241b14067d039a8065ac8367
http://europepmc.org/articles/PMC4623119
http://europepmc.org/articles/PMC4623119
Publikováno v:
Frontiers in Immunology
Post-translational modifications of DNA and histones are epigenetic mechanisms, which affect the chromatin structure, ultimately leading to gene expression changes. A number of different epigenetic enzymes are actively involved in the addition or the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20dbc1e7887abf5df0d2c41758d6ae01
https://doi.org/10.3389/fimmu.2015.00487
https://doi.org/10.3389/fimmu.2015.00487
Publikováno v:
Cell & Bioscience
Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell. Genetic modifications include loss or amplification of DNA, loss of heterozygosity (LOH) as well as gene muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a900885d2af9439ce8fc357d72172161
http://europepmc.org/articles/PMC4422217
http://europepmc.org/articles/PMC4422217