Výsledky vyhledávání - "Karolina Theodoridis"

Assessment of cytocompatibility and mechanical properties of detergent-decellularized ovine pericardial tissue

Autor: Tobias Goecke, A. Mogaldea, Igor Tudorache, Andres Hilfiker, Karolina Theodoridis, Serghei Cebotari, A. Haverich

Publikováno v: The International Journal of Artificial Organs. 42:628-635

Background: Autologous pericardium is widely used for the repair of different sized cardiovascular defects. However, its use is limited especially in redo cardiac surgery. We developed an engineered tissue based on decellularized pericardium reseeded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7923bc7701e4d1670d8b2979c18ecf43
https://doi.org/10.1177/0391398819850583

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^{Six-Year-Old Sheep as a Clinically Relevant Large Animal Model for Aortic Valve Replacement Using Tissue-Engineered Grafts Based on Decellularized Allogenic Matrix}

Autor: Andres Hilfiker, Christoph Bara, Alexandru Calistru, Axel Haverich, Tanja Meyer, Igor Tudorache, Samir Sarikouch, Karolina Theodoridis, Serghei Cebotari

Publikováno v: Tissue Engineering Part C: Methods. 23:953-963

Tissue-engineered (TE) grafts based on decellularized grafts have shown very promising results in preclinical and clinical studies. However, in animal models valves have either been tested in juvenile models or in the clinically less relevant pulmona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::802de22622db85420ffd5d4ec1161a24
https://doi.org/10.1089/ten.tec.2017.0163

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Decellularization combined with enzymatic removal of N-linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model

Autor: Katja Findeisen, Axel Haverich, Klaus Hoeffler, Samir Sarikouch, Karolina Theodoridis, Robert Ramm, Tobias Goecke, Igor Tudorache, Serghei Cebotari, Andres Hilfiker, Anatol Ciubotaru

Publikováno v: XenotransplantationREFERENCES. 27(2)

Background Limited availability of decellularized allogeneic heart valve substitutes restricts the clinical application thereof. Decellularized xenogeneic valves might constitute an attractive alternative; however, increased immunological hurdles hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e23a7943b187ad82751efa88b5663
https://pubmed.ncbi.nlm.nih.gov/31769101

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Early Insight Into In Vivo Recellularization of Cell-Free Allogenic Heart Valves

Autor: Jan Lukas Robertus, Karolina Theodoridis, Dietmar Boethig, Dmitry Bobylev, Günther Laufer, Alexander Horke, Lavinia Neubert, Igor Tudorache, Axel Haverich, Serghei Cebotari, Philipp Beerbaum, Andres Hilfiker, Martin Andreas, Samir Sarikouch, Kristin Teiken, Danny Jonigk

Publikováno v: The Annals of Thoracic Surgery

Background Unlike the vast amount of animal data available on the recellularization of allogenic decellularized heart valves (DHVs), there have only been sporadic histologic reports on such grafts in humans. Methods Two experienced cardiac pathologis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd4f51f7fbdb7b4c0f8fa0553dd662

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Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves

Autor: Axel Haverich, Karolina Theodoridis, Katja Findeisen, Andres Hilfiker, Sotirios Korossis, Robert Ramm, Birgit Andrée, Janina Müller

Publikováno v: Acta Biomaterialia. 43:71-77

Non-fixed, decellularized allogeneic heart valve scaffolds seem to be the best choice for heart valve replacement, their availability, however, is quite limited. Cryopreservation could prolong their shelf-life, allowing for their ideal match to a rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dd9eedb36976686f2e583fbc8b3da0
https://doi.org/10.1016/j.actbio.2016.07.013

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Double semilunar valve replacement in complex congenital heart disease using decellularized homografts

Autor: Philipp Beerbaum, Dietmar Boethig, Igor Tudorache, Alexander Horke, Karolina Theodoridis, Samir Sarikouch, Serghei Cebotari, Axel Haverich, Harald Bertram, Dmitry Bobylev, Tomislav Cvitkovic, Bahar Söylen

Publikováno v: Interactive CardioVascular and Thoracic Surgery

OBJECTIVES: Patients with complex congenital heart disease often require multiple reoperations, resulting in increased rates of operative morbidity and mortality. Decellularized heart valves (DHVs) have led to reduced reoperation rates compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3571283999471c774977dc7a59cc6c3
https://pubmed.ncbi.nlm.nih.gov/30016427

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In vivo performance of freeze-dried decellularized pulmonary heart valve allo- and xenografts orthotopically implanted into juvenile sheep

Autor: Klaus Höffler, Serghei Cebotari, Igor Tudorache, Andrés Vásquez Rivera, Robert Ramm, Willem F. Wolkers, Axel Haverich, Andres Hilfiker, Anatol Ciubotaru, Samir Sarikouch, Tobias Goecke, Karolina Theodoridis

Publikováno v: Acta biomaterialia. 68

The decellularization of biological tissues decreases immunogenicity, allows repopulation with cells, and may lead to improved long-term performance after implantation. Freeze drying these tissues would ensure off-the-shelf availability, save storage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302985d0f02e2b32801d8e46bced38b2
https://pubmed.ncbi.nlm.nih.gov/29191508

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Tissue Engineering of Vein Valves Based on Decellularized Natural Matrices

Autor: A. Mogaldea, Tobias Goecke, Karolina Theodoridis, Axel Haverich, Serghei Cebotari, Andres Hilfiker

Publikováno v: Cells, tissues, organs. 204(3-4)

Valvular repair or transplantation, designed to restore the venous valve function of the legs, has been proposed as treatment in chronic venous insufficiency. Available grafts or surgeries have provided limited durability so far. Generating venous va

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https://pubmed.ncbi.nlm.nih.gov/28787732

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Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation

Autor: Dagmar Hartung, Andres Hilfiker, Igor Tudorache, Klaus Höffler, Karolina Theodoridis, Tanja Meyer, Axel Haverich, Serghei Cebotari, Hassina Baraki, Christoph Bara, Samir Sarikouch

Publikováno v: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 49(4)

OBJECTIVES Pulmonary autografts (PAs) represent the substitute of choice for aortic valve (AV) replacement, especially in children and young adults. Similarly, decellularized aortic valve allografts (DAVAs) have shown excellent mid-term function when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf30bfe6e6066b69144d2d5eea982e41
https://pubmed.ncbi.nlm.nih.gov/26503725

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