Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Karolina Tecza"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The study describes a relationship between the 3′UTR variants, clinicopathological parameters and response to chemotherapy. We analyzed 33 germline polymorphisms in 3′UTRs of ADME genes in 305 breast cancer women treated with FAC regime. Clinical
Publikováno v:
Oncotarget
The differences in patients' response to the same medication, toxicity included, are one of the major problems in breast cancer treatment. Chemotherapy toxicity makes a significant clinical problem due to decreased quality of life, prolongation of tr
Autor:
J. Pamula Pilat, Karolina Tecza, Ewa A. Grzybowska, Elżbieta Nowara, M. Nycz Bochenek, Joanna Huszno
Publikováno v:
Cancer Research. 77:P2-07
Introduction: Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. The aim
Publikováno v:
Oncotarget
// Karolina Tecza 1 , Jolanta Pamula-Pilat 1 , Joanna Lanuszewska 1 , Ewa Grzybowska 1 1 Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Warsa
Autor:
Jolanta Pamuła Piłat, Ewa Grzybowska, Magdalena Budryk, Joanna Huszno, Zofia Kołosza, Elżbieta Nowara, Karolina Tecza
Publikováno v:
Oncology. 90:193-198
Objective: The suppressor gene CHEK2 encodes a cell cycle checkpoint kinase, involved in cell cycle regulation, apoptosis and response to DNA damage. The aim of this study was to analyze the differences between CHEK2 mutation carriers (CHEK2*1100delC
Autor:
Dorota Kula, Anna Jedynak, Ewa Grzybowska, Agnieszka Boratyn-Nowicka, Karolina Tecza, Sebastian Giebel, Jolanta Pamula-Pilat, Monika Kowal, Irena Frydecka, Lidia Karabon
Publikováno v:
Human Immunology. 75:508-513
Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly poly
Autor:
Per Lenner, Karolina Tecza, Asta Försti, Robert Johansson, Kerstin Enquist, Ewa A. Grzybowska, Roger Henriksson, Verena Varadi, Kari Hemminki, Melanie Bevier, Dorota Butkiewicz, Jolanta Pamula-Pilat
Publikováno v:
Breast Cancer Research and Treatment. 129:235-245
Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic va
Publikováno v:
Hereditary Cancer in Clinical Practice
Single nucleotide polymorphisms modulate the risk of developing ovarian cancer during lifetime. In this study we analyzed 12 polymorphic variants and 2 deletions in PGR, ABCB1, ABCG2, GSTT1, GSTM1, GSTP1, ATM, TP53 and ATP7B genes. Ten genetic modifi
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Ovarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic and developed during treatment, is sometimes observed. These facts underscore the need for new markers of ovarian cance
Publikováno v:
The Breast. 32:S34