Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Karolina Pytka"'
Autor:
Elżbieta Żmudzka, Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Jolanta Jaśkowska, Marcin Kołaczkowski, Jacek Sapa, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 399 (2023)
Memory impairments constitute a significant problem worldwide, and the COVID-19 pandemic dramatically increased the prevalence of cognitive deficits. Patients with cognitive deficits, specifically memory disturbances, have underlying comorbid conditi
Externí odkaz:
https://doaj.org/article/14281d0bf07a4c3fa2b1e60717b985a3
Autor:
Elżbieta Żmudzka, Klaudia Lustyk, Monika Głuch-Lutwin, Małgorzata Wolak, Jolanta Jaśkowska, Marcin Kołaczkowski, Jacek Sapa, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 175 (2023)
Depression, anxiety, and schizophrenia may coexist in psychiatric patients. Moreover, these disorders are very often associated with cognitive impairments. However, pharmacotherapy of these conditions remains challenging due to limited drug effective
Externí odkaz:
https://doaj.org/article/01f15a7cad704a1ca5769770a4dc6d63
Autor:
Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Barbara Filipek, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1256 (2022)
Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial infarction. The limited efficacy and proarrhythmic potential of the available drugs require searching
Externí odkaz:
https://doaj.org/article/4e067cc7310447c48c9235658364a46b
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1065 (2021)
Arrhythmia is a quivering or irregular heartbeat that can often lead to blood clots, stroke, heart failure, and other heart-related complications. The limited efficacy and safety of antiarrhythmic drugs require the design of new compounds. Previous r
Externí odkaz:
https://doaj.org/article/919015ed90c64d18ab47d372690bf405
Autor:
Kinga Sałaciak, Natalia Malikowska-Racia, Klaudia Lustyk, Agata Siwek, Monika Głuch-Lutwin, Grzegorz Kazek, Justyna Popiół, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 744 (2021)
The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates
Externí odkaz:
https://doaj.org/article/ffe77bfce64941849e5dbfd0d2020f70
Autor:
Karolina Pytka, Monika Głuch-Lutwin, Elżbieta Żmudzka, Kinga Sałaciak, Agata Siwek, Katarzyna Niemczyk, Maria Walczak, Magdalena Smolik, Adrian Olczyk, Adam Gałuszka, Jarosław Śmieja, Barbara Filipek, Jacek Sapa, Marcin Kołaczkowski, Katarzyna Pańczyk, Anna Waszkielewicz, Henryk Marona
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Numerous studies have proven that both stimulation and blockade of 5-HT1A and the blockade of 5-HT7 receptors might cause the anxiolytic-like effects. Biased agonists selectively activate specific signaling pathways. Therefore, they might offer novel
Externí odkaz:
https://doaj.org/article/8dd1f0a7d698424791fe883f5d6e889d
Autor:
Karolina Pytka, Klaudia Lustyk, Elżbieta Żmudzka, Magdalena Kotańska, Agata Siwek, Małgorzata Zygmunt, Agnieszka Dziedziczak, Joanna Śniecikowska, Adrian Olczyk, Adam Gałuszka, Jarosław Śmieja, Anna Maria Waszkielewicz, Henryk Marona, Barbara Filipek, Jacek Sapa, Szczepan Mogilski
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine
Externí odkaz:
https://doaj.org/article/f6d6d09f1b984a7ca25590e6c5801f96
Autor:
Karolina Pytka, Monika Głuch-Lutwin, Joanna Knutelska, Magdalena Jakubczyk, Anna Waszkielewicz, Magdalena Kotańska
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165495 (2016)
Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of du
Externí odkaz:
https://doaj.org/article/be078a429b4d4869af099ba89021ca1e
Autor:
Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Barbara Mordyl, Monika Głuch-Lutwin, Grzegorz Kazek, Jacek Sapa, Karolina Pytka
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141327 (2015)
The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity. We compared the effe
Externí odkaz:
https://doaj.org/article/7c72d98cccff4ce99d65fbc8830de184
Autor:
Karolina Pytka, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Grzegorz Kazek, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Marian Błachuta, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Anna Wesołowska
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142499 (2015)
The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)etho
Externí odkaz:
https://doaj.org/article/3bead66349ca4528a63d2d7dcfb6dfbd