Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Karolina Piecyk"'
The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering
Autor:
Karol Kurpiejewski, Anna Stankiewicz-Drogon, Karolina Piecyk, Eliza Rajkowska, Paulina Skrzypczyk, Jingping Geng, Edward Darzynkiewicz, Renata Grzela, Marzena Jankowska-Anyszka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The technology of mRNA-based drugs is currently being intensively developed and implemented. Medical products of this type are already being used as viral vaccines and could potentially find application in a wide range of diseases. The tremendous int
Externí odkaz:
https://doaj.org/article/98522c5c546a4021a4a4c25a75f139d2
Autor:
Karol Kurpiejewski, Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel, Kazimierz Chmurski, Sebastian Kmiecik, Marzena Jankowska-Anyszka
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 632 (2024)
In the fight against cancer, researchers have turned their attention to the eukaryotic initiation factor eIF4E, a protein whose increased level is strongly correlated with the development and progression of various types of cancer. Among the numerous
Externí odkaz:
https://doaj.org/article/18caed14f0cd49918611fe41c90e49f2
Autor:
Paulina Pietrow, Aleksandra Ferenc-Mrozek, Karolina Piecyk, Elzbieta Bojarska, Edward Darzynkiewicz, Marzena Jankowska-Anyszka
Publikováno v:
ACS Omega, Vol 4, Iss 17, Pp 17576-17580 (2019)
Externí odkaz:
https://doaj.org/article/35601017d39a46b8958cbaacf5849a6a
Autor:
Karolina Drabik, Dominika Malińska, Karolina Piecyk, Grażyna Dębska-Vielhaber, Stefan Vielhaber, Jerzy Duszyński, Joanna Szczepanowska
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 938 (2021)
Although the sporadic form of Alzheimer’s disease (AD) is the prevalent form, the cellular events underlying the disease pathogenesis have not been fully characterized. Accumulating evidence points to mitochondrial dysfunction as one of the events
Externí odkaz:
https://doaj.org/article/cbfc1c781273493ba8be311df1637f06
Autor:
Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska‐Anyszka, Karolina Piecyk
Publikováno v:
ChemMedChem. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c137628a95a853bc2512cfa03a343f2
https://doi.org/10.1002/cmdc.202200490
https://doi.org/10.1002/cmdc.202200490
Autor:
Remigiusz Worch, Nadejda L. Korneeva, Paulina Pietrow, Karolina Piecyk, Marzena Jankowska-Anyszka, Thomas C. Arnold
Publikováno v:
Bioconjugate chemistry. 31(4)
The development of targeted anticancer drugs has been one of the most challenging goals of current research. Eukaryotic translation initiation factor 4E (eIF4E) is an oncogene that stimulates mRNA translation via binding to the 5' endcap structure. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da40d06d1a5514f958a261a9d8d437dd
https://pubmed.ncbi.nlm.nih.gov/32227927
https://pubmed.ncbi.nlm.nih.gov/32227927
Publikováno v:
Tetrahedron Letters. 58:3037-3040
The modification of various important nucleotide-based molecules (such as nucleotides, RNA, DNA, oligonucleotides) with fluorophores, affinity tags and reactive moieties is of enormous utility for studying their localization, structure and dynamics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27064f0277911f6872eba9ae1fae4ae6
https://doi.org/10.1016/j.tetlet.2017.06.060
https://doi.org/10.1016/j.tetlet.2017.06.060
Autor:
Maria Janowska, Karol Kamel, Sebastian Kmiecik, Marzena Jankowska-Anyszka, Paulina Pietrow, Karolina Piecyk, Maciej Lukaszewicz
Publikováno v:
Bioorganic Chemistry. 96:103583
Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99c7f333537407de0b7e1200ef62b1
https://doi.org/10.1016/j.bioorg.2020.103583
https://doi.org/10.1016/j.bioorg.2020.103583
Autor:
Karolina Piecyk, Magdalena Rudzińska, Ilona Kocmik, Edward Darzynkiewicz, Marzena Jankowska-Anyszka, Renata Grzela, Anna Niedzwiecka
Publikováno v:
Cell cycle (Georgetown, Tex.). 17(13)
Nowadays gene manipulation techniques (���DNA therapy���) undergo progressive development and become widely used in industry and medicine. Since new advances in mRNA technologies are capable for obtaining particles with increased stabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1e607141649266c75eea846320b8bb
https://pubmed.ncbi.nlm.nih.gov/29954234
https://pubmed.ncbi.nlm.nih.gov/29954234
Publikováno v:
RNA. 20:1539-1547
Synthetic analogs of the 5′ end of mRNA (cap structure) are widely used in molecular studies on mechanisms of cellular processes such as translation, intracellular transport, splicing, and turnover. The best-characterized cap binding protein is tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ff1e3eef0576000d44dacd75db9a1d
https://doi.org/10.1261/rna.046193.114
https://doi.org/10.1261/rna.046193.114