Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Karolina Palucka A"'
Autor:
Bishesh Subba, Mohammed Toufiq, Fuadur Omi, Marina Yurieva, Taushif Khan, Darawan Rinchai, Karolina Palucka, Damien Chaussabel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The identification of optimal candidate genes from large-scale blood transcriptomic data is crucial for developing targeted assays to monitor immune responses. Here, we introduce a novel, optimized large language model (LLM)-based approach f
Externí odkaz:
https://doaj.org/article/ad20bd7ebe984191b76d3ee6fcf8d717
Autor:
Victor G. Wang, Zichao Liu, Jan Martinek, Ali Foroughi pour, Jie Zhou, Hannah Boruchov, Kelly Ray, Karolina Palucka, Jeffrey H. Chuang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The tumor microenvironment (TME) and the cellular interactions within it can be critical to tumor progression and treatment response. Although technologies to generate multiplex images of the TME are advancing, the many ways in which TME ima
Externí odkaz:
https://doaj.org/article/1f4280d59b514f9a94da98669d1d6645
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103155- (2024)
Summary: Humanized mice, defined as mice with human immune systems, have become an emerging model to study human hematopoiesis, infectious disease, and cancer. Here, we describe the techniques to generate humanized NSGF6 mice using adult human CD34+
Externí odkaz:
https://doaj.org/article/cb4168375e2a454492a1e19975ce7d30
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109238- (2024)
Summary: Pre-clinical use of humanized mice transplanted with CD34+ hematopoietic stem and progenitor cells (HSPCs) is limited by insufficient engraftment with adult non-mobilized HSPCs. Here, we developed a novel immunodeficient mice based on NOD-SC
Externí odkaz:
https://doaj.org/article/82ff2da9444a43a6a007bc143d2a310b
Autor:
Mohammed Toufiq, Darawan Rinchai, Eleonore Bettacchioli, Basirudeen Syed Ahamed Kabeer, Taushif Khan, Bishesh Subba, Olivia White, Marina Yurieva, Joshy George, Noemie Jourde-Chiche, Laurent Chiche, Karolina Palucka, Damien Chaussabel
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-33 (2023)
Abstract Background Feature selection is a critical step for translating advances afforded by systems-scale molecular profiling into actionable clinical insights. While data-driven methods are commonly utilized for selecting candidate genes, knowledg
Externí odkaz:
https://doaj.org/article/c124b5b791564fa691f713fc426cce8b
Autor:
Diana Cadena Castaneda, Sonia Jangra, Marina Yurieva, Jan Martinek, Megan Callender, Matthew Coxe, Angela Choi, Juan García-Bernalt Diego, Te-Chia Wu, Florentina Marches, Damien Chaussabel, Adolfo García-Sastre, Michael Schotsaert, Adam Williams, Karolina Palucka
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102735- (2023)
Summary: Primary human lung organoid-derived air-liquid interface (ALI) cultures serve as a physiologically relevant model to study human airway epithelium in vitro. Here, we present a protocol for establishing these cultures from cryopreserved human
Externí odkaz:
https://doaj.org/article/b465519e6c2441c6bdb976ce7b5806cd
Autor:
Diana Cadena Castaneda, Sonia Jangra, Marina Yurieva, Jan Martinek, Megan Callender, Matthew Coxe, Angela Choi, Juan García-Bernalt Diego, Jianan Lin, Te-Chia Wu, Florentina Marches, Damien Chaussabel, Peter Yu, Andrew Salner, Gabrielle Aucello, Jonathan Koff, Briana Hudson, Sarah E. Church, Kara Gorman, Esperanza Anguiano, Adolfo García-Sastre, Adam Williams, Michael Schotsaert, Karolina Palucka
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107374- (2023)
Summary: The COVID-19 pandemic continues to be a health crisis with major unmet medical needs. The early responses from airway epithelial cells, the first target of the virus regulating the progression toward severe disease, are not fully understood.
Externí odkaz:
https://doaj.org/article/b51b64e50b72469895f79ce437b3fedc
Autor:
Jan Martinek, Ryan C Fields, Scott Gettinger, Karolina Palucka, Katerina Politi, Jun Zhao, Ye Bi, Richard A Flavell, Frank Detterbeck, Obi Griffith, Liang Shan, Malachi Griffith, Michael Chiorazzi, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Esen Sefik, Jacqueline Mudd, S Peter Goedegebuure, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Yuval Kluger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as
Externí odkaz:
https://doaj.org/article/9479165cf09946f8937b35f6027d8425
Autor:
Jan Martinek, Te-Chia Wu, Lili Sun, Jianan Lin, Kyung In Kim, Florentina Marches, Paul Robson, Joshy George, Karolina Palucka
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101698- (2022)
Summary: We describe a pipeline for optimized and streamlined multiplexed immunofluorescence-guided laser capture microdissection allowing the harvest of individual cells based on their phenotype and tissue localization for transcriptomic analysis wi
Externí odkaz:
https://doaj.org/article/77f275be7d9f486db7fcb7f4f44effee
Autor:
Matthew C. Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R. Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J. Theodore Phillips, Goran Klintmalm, Anne O’Garra, Matthew Berry, Chloe Bloom, Robert J. Wilkinson, Christine M. Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The blood transcriptome of human subjects can be profiled on an almost routine basis in translational research settings. Here the authors show that a fixed and well-characterized repertoire of transcriptional modules can be employed as a reusable fra
Externí odkaz:
https://doaj.org/article/53730b2675634242a15233e155dbf8a0