Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Karolina Nemes"'
Autor:
Karolina Nemes, Pascal D. Johann, Mona Steinbügl, Miriam Gruhle, Susanne Bens, Denis Kachanov, Margarita Teleshova, Peter Hauser, Thorsten Simon, Stephan Tippelt, Wolfgang Eberl, Martin Chada, Vicente Santa-Maria Lopez, Lorenz Grigull, Pablo Hernáiz-Driever, Matthias Eyrich, Jane Pears, Till Milde, Harald Reinhard, Alfred Leipold, Marianne van de Wetering, Maria João Gil-da-Costa, Georg Ebetsberger-Dachs, Kornelius Kerl, Andreas Lemmer, Heidrun Boztug, Rhoikos Furtwängler, Uwe Kordes, Christian Vokuhl, Martin Hasselblatt, Brigitte Bison, Thomas Kröncke, Patrick Melchior, Beate Timmermann, Joachim Gerss, Reiner Siebert, Michael C. Frühwald
Publikováno v:
Cancers, Vol 14, Iss 9, p 2185 (2022)
Introduction: Malignant rhabdoid tumors (MRT) predominantly affect infants and young children. Patients below six months of age represent a particularly therapeutically challenging group. Toxicity to developing organ sites limits intensity of treatme
Externí odkaz:
https://doaj.org/article/e0aa461bd75246d2a8a09c8818dc7cc2
Autor:
Karolina Nemes, Anna Sebestyén, Agnes Márk, Melinda Hajdu, István Kenessey, Tamás Sticz, Eszter Nagy, Gábor Barna, Zsófia Váradi, Gábor Kovács, László Kopper, Monika Csóka
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59335 (2013)
Modern treatment strategies have improved the prognosis of childhood ALL; however, treatment still fails in 25-30% of patients. Further improvement of treatment may depend on the development of targeted therapies. mTOR kinase, a central mediator of s
Externí odkaz:
https://doaj.org/article/4c67f00d0a584e2099a42e5f698cce08
Autor:
Paul D. Aridgides, Anita Mahajan, Bree Eaton, Dongliang Wang, Beate Timmerman, Michael C. Früwald, Karolina Nemes, Jared Deck, Kai Yamasaki, Katja Von Hoff, Lucie Lafay‐Cousin, Alyssa Reddy, Andrea C. Lo
Publikováno v:
Pediatric Blood & Cancer. 70
in press
Autor:
Noëlle Weingertner, Amaury Leruste, Daniel Orbach, Nicolas Servant, Franck Bourdeaut, Uwe Kordes, Gaëlle Pierron, Nadège Corradini, Dominique Ranchère, Alexandra Leary, Alice Corsia, Ulrich Schüller, Joanna Cyrta, Michael C. Frühwald, Mamy Andrianteranagna, Dörthe Holdhof, Karolina Nemes, Olivier Delattre, Paul Fréneaux, Jonathan W. Bush, Julien Masliah-Planchon, Anne Brouchet, Natacha Entz-Werle, Marie-Pierre Castex
Publikováno v:
The Journal of Pathology. 255:1-15
Extracranial rhabdoid tumours (ECRTs) are an aggressive malignancy of infancy and early childhood. The vast majority of cases demonstrate inactivation of SMARCB1 (ECRTSMARCB1 ) on a background of a remarkably stable genome, a low mutational burden, a
Publikováno v:
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 194(8)
Autor:
Roy W. R. Dudley, Reiner Siebert, Christian Thomas, Karolina Nemes, Francesca Zin, Michael C. Frühwald, Tenzin Gayden, Rajiv Pathak, Marcel Kool, Steffen Albrecht, Florian Oyen, Pascal Johann, Martin Hasselblatt, Susanne Bens, Nada Jabado, Uwe Kordes, Werner Paulus, Jason Karamchandani, Ganjam V. Kalpana
Publikováno v:
Acta Neuropathologica
Loss of nuclear SMARCB1 (INI1/hSNF5/BAF47) protein expression due to biallelic mutations of the SMARCB1 tumor suppressor gene is a hallmark of atypical teratoid/rhabdoid tumors (ATRT), but the presence of cytoplasmic SMARCB1 protein in these tumors h
Autor:
Aniello Federico, Christian Thomas, Katarzyna Miskiewicz, Niklas Woltering, Francesca Zin, Karolina Nemes, Brigitte Bison, Pascal D. Johann, Debra Hawes, Susanne Bens, Uwe Kordes, Steffen Albrecht, Hildegard Dohmen, Peter Hauser, Kathy Keyvani, Frank K. H. van Landeghem, Eva Løbner Lund, David Scheie, Christian Mawrin, Camelia-Maria Monoranu, Benedicte Parm Ulhøi, Torsten Pietsch, Harald Reinhard, Markus J. Riemenschneider, Astrid Sehested, David Sumerauer, Reiner Siebert, Werner Paulus, Michael C. Frühwald, Marcel Kool, Martin Hasselblatt
Publikováno v:
Federico, A, Thomas, C, Miskiewicz, K, Woltering, N, Zin, F, Nemes, K, Bison, B, Johann, P D, Hawes, D, Bens, S, Kordes, U, Albrecht, S, Dohmen, H, Hauser, P, Keyvani, K, van Landeghem, F K H, Lund, E L, Scheie, D, Mawrin, C, Monoranu, C M, Parm Ulhøi, B, Pietsch, T, Reinhard, H, Riemenschneider, M J, Sehested, A, Sumerauer, D, Siebert, R, Paulus, W, Frühwald, M C, Kool, M & Hasselblatt, M 2022, ' ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance ', Acta Neuropathologica, vol. 143, no. 6, pp. 697-711 . https://doi.org/10.1007/s00401-022-02424-5
Federico, A, Thomas, C, Miskiewicz, K, Woltering, N, Zin, F, Nemes, K, Bison, B, Johann, P D, Hawes, D, Bens, S, Kordes, U, Albrecht, S, Dohmen, H, Hauser, P, Keyvani, K, van Landeghem, F K H, Lund, E L, Scheie, D, Mawrin, C, Monoranu, C-M, Parm Ulhøi, B, Pietsch, T, Reinhard, H, Riemenschneider, M J, Sehested, A, Sumerauer, D, Siebert, R, Paulus, W, Frühwald, M C, Kool, M & Hasselblatt, M 2022, ' ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance ', Acta Neuropathologica, vol. 143, no. 6, pp. 697-711 . https://doi.org/10.1007/s00401-022-02424-5
Federico, A, Thomas, C, Miskiewicz, K, Woltering, N, Zin, F, Nemes, K, Bison, B, Johann, P D, Hawes, D, Bens, S, Kordes, U, Albrecht, S, Dohmen, H, Hauser, P, Keyvani, K, van Landeghem, F K H, Lund, E L, Scheie, D, Mawrin, C, Monoranu, C-M, Parm Ulhøi, B, Pietsch, T, Reinhard, H, Riemenschneider, M J, Sehested, A, Sumerauer, D, Siebert, R, Paulus, W, Frühwald, M C, Kool, M & Hasselblatt, M 2022, ' ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance ', Acta Neuropathologica, vol. 143, no. 6, pp. 697-711 . https://doi.org/10.1007/s00401-022-02424-5
Atypical teratoid/rhabdoid tumor (ATRT) is an aggressive central nervous system tumor characterized by loss of SMARCB1/INI1 protein expression and comprises three distinct molecular groups, ATRT–TYR, ATRT–MYC and ATRT–SHH. ATRT–SHH represents
Autor:
H. Boztug, Uwe Kordes, Christian P. Kratz, Kornelius Kerl, Franck Bourdeaut, K. Jahnukainen, V. Ridola, M. Jorgensen, Iris Kventsel, K. Katsibardi, Karolina Nemes, R. Farah, E. Stutz, M. C. A. Cornips, K. W. Pajtler, Michael C. Frühwald, S. Glentis, D. G. R. Evans, Steffen Hirsch
Publikováno v:
Familial Cancer
Frühwald, M C, Nemes, K, Boztug, H, Cornips, M C A, Evans, D G, Farah, R, Glentis, S, Jorgensen, M, Katsibardi, K, Hirsch, S, Jahnukainen, K, Kventsel, I, Kerl, K, Kratz, C P, Pajtler, K W, Kordes, U, Ridola, V, Stutz, E & Bourdeaut, F 2021, ' Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition : a report from the SIOPE Host Genome Working Group ', Familial Cancer, vol. 20, pp. 305-316 . https://doi.org/10.1007/s10689-021-00229-1
Frühwald, M C, Nemes, K, Boztug, H, Cornips, M C A, Evans, D G, Farah, R, Glentis, S, Jorgensen, M, Katsibardi, K, Hirsch, S, Jahnukainen, K, Kventsel, I, Kerl, K, Kratz, C P, Pajtler, K W, Kordes, U, Ridola, V, Stutz, E & Bourdeaut, F 2021, ' Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition : a report from the SIOPE Host Genome Working Group ', Familial Cancer, vol. 20, pp. 305-316 . https://doi.org/10.1007/s10689-021-00229-1
The rhabdoid tumor (RT) predisposition syndromes 1 and 2 (RTPS1 and 2) are rare genetic conditions rendering young children vulnerable to an increased risk of RT, malignant neoplasms affecting the kidney, miscellaneous soft-part tissues, the liver an
Autor:
Karolina Nemes, Yvonne Dzierma, Karin Dieckmann, Jochen Hubertus, Clemens Magnus Meier, Rhoikos Furtwängler, Sabine Kroiss, Christian Vokuhl, Steven W. Warmann, Patrick Melchior, Norbert Graf, Michael C. Frühwald, Leo Kager, Christian Rübe, Jens-Peter Schenk, I Leuschner
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 108:667-675
PURPOSE Rhabdoid tumor of the kidney (RTK) is one of the most aggressive childhood renal tumors. Overall survival ranges from 22% to 47%. The indication for radiation therapy (RT) in usually very young patients is an ongoing discussion. Recent protoc
Autor:
Christian Thomas, Aniello Federico, Susanne Bens, Mats Hellström, Olivera Casar-Borota, Uwe Kordes, Julia E Neumann, Matthias Dottermusch, Fausto E Rodriguez, Andrea C Lo, Sylvia Cheng, Glenda Hendson, Juliette Hukin, Christian Hartmann, Arend Koch, David Capper, Reiner Siebert, Werner Paulus, Karolina Nemes, Pascal D Johann, Michael C Frühwald, Marcel Kool, Martin Hasselblatt
Publikováno v:
Neuro-Oncology. 24:i3-i4
Most atypical teratoid/rhabdoid tumors (ATRTs) occur in infants, but children and adolescents may also be affected. ATRTs occurring in older patients often comprise the molecular subgroup ATRT-MYC. Recently, central nervous system low-grade diffusely