Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Karolina Mitusińska"'
Autor:
Gol Mohammad Dorrazehi, Matthias Winkle, Martin Desmet, Vincent Stroobant, Gamze Tanriver, Hervé Degand, Damien Evrard, Benoît Desguin, Pierre Morsomme, Jacob Biboy, Joe Gray, Karolina Mitusińska, Artur Góra, Waldemar Vollmer, Patrice Soumillion
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Penicillin binding proteins (PBPs) are involved in biosynthesis, remodeling and recycling of peptidoglycan (PG) in bacteria. PBP-A from Thermosynechococcus elongatus belongs to a cyanobacterial family of enzymes sharing close structural and
Externí odkaz:
https://doaj.org/article/d1d2fa49952f4ef1b225b6e3b51a7fda
Autor:
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 193-205 (2022)
Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with
Externí odkaz:
https://doaj.org/article/def315439ad94a25a586b45f7119cde7
Autor:
Maria Bzówka, Karolina Mitusińska, Agata Raczyńska, Tomasz Skalski, Aleksandra Samol, Weronika Bagrowska, Tomasz Magdziarz, Artur Góra
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010119 (2022)
The evolutionary variability of a protein's residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are cons
Externí odkaz:
https://doaj.org/article/9a363a48ce7e4d71898579d0ae0eb9b1
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 355-365 (2020)
Water molecules maintain proteins’ structures, functions, stabilities and dynamics. They can occupy certain positions or pass quickly via a protein’s interior. Regardless of their behaviour, water molecules can be used for the analysis of protein
Externí odkaz:
https://doaj.org/article/e0da40d7445146adb4300dbaed5fb31c
Autor:
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2198-2199 (2022)
Externí odkaz:
https://doaj.org/article/58a5b072c71e4615b029fcc215c2866c
Autor:
Karolina Mitusińska, Artur Góra, Anna Bogdańska, Agnieszka Rożdżyńska-Świątkowska, Anna Tylki-Szymańska, Aleksandra Jezela-Stanek
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 398 (2022)
Congenital Disorders of Glycosylation (CDG) are multisystemic metabolic disorders showing highly heterogeneous clinical presentation, molecular etiology, and laboratory results. Here, we present different transferrin isoform patterns (obtained by iso
Externí odkaz:
https://doaj.org/article/d71b8bd7fdd84fe4baf776df3cce689f
Autor:
André Fischer, Manuel Sellner, Karolina Mitusińska, Maria Bzówka, Markus A. Lill, Artur Góra, Martin Smieško
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2065 (2021)
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious global health threat. Since no specific therapeutics are available, researchers around the world screened compounds to inhibit various molecular targets
Externí odkaz:
https://doaj.org/article/cedba416c7064ac4977bbda8cf4fd4bd
Autor:
Maria Bzówka, Karolina Mitusińska, Agata Raczyńska, Aleksandra Samol, Jack A. Tuszyński, Artur Góra
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3099 (2020)
The novel coronavirus whose outbreak took place in December 2019 continues to spread at a rapid rate worldwide. In the absence of an effective vaccine, inhibitor repurposing or de novo drug design may offer a longer-term strategy to combat this and f
Externí odkaz:
https://doaj.org/article/3e2a5e66c58a4e1b8d3c0da63f567b41
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2293 (2020)
Loops are the most variable and unorganized elements of the secondary structure of proteins. Their ability to shift their shape can play a role in the binding of small ligands, enzymatic catalysis, or protein−protein interactions. Due to the loop f
Externí odkaz:
https://doaj.org/article/b5c9e06f6db540269ca8d5f27b95c190
Autor:
Kalyanasundaram Subramanian, Artur Góra, Ruud Spruijt, Karolina Mitusińska, Maria Suarez-Diez, Vitor Martins Dos Santos, Peter J Schaap
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198990 (2018)
D-amino acid oxidase (DAAO) degrades D-amino acids to produce α-ketoacids, hydrogen peroxide and ammonia. DAAO has often been investigated and engineered for industrial and clinical applications. We combined information from literature with a detail
Externí odkaz:
https://doaj.org/article/c1901d9d234145f68756cd2fee2dbd9c