IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen

Autor: Marta Libura, Emilia Bialopiotrowicz, Sebastian Giebel, Agnieszka Wierzbowska, Gail J. Roboz, Beata Piatkowska-Jakubas, Marta Pawelczyk, Patryk Gorniak, Katarzyna Borg, Magdalena Wojtas, Izabella Florek, Karolina Matiakowska, Bozena Jazwiec, Iwona Solarska, Monika Noyszewska-Kania, Karolina Piechna, Magdalena Zawada, Sylwia Czekalska, Zoriana Salamanczuk, Karolina Karabin, Katarzyna Wasilewska, Monika Paluszewska, Elzbieta Urbanowska, Justyna Gajkowska-Kulik, Grazyna Semenczuk, Justyna Rybka, Tomasz Wrobel, Anna Ejduk, Dariusz Kata, Sebastian Grosicki, Tadeusz Robak, Agnieszka Pluta, Agata Kominek, Katarzyna Piwocka, Karolina Pyziak, Agnieszka Sroka-Porada, Anna Wrobel, Agnieszka Przybylowicz, Marzena Wojtaszewska, Krzysztof Lewandowski, Lidia Gil, Agnieszka Piekarska, Wanda Knopinska, Lukasz Bolkun, Krzysztof Warzocha, Kazimierz Kuliczkowski, Tomasz Sacha, Grzegorz Basak, Wieslaw Wiktor Jedrzejczak, Jerzy Holowiecki, Przemysław Juszczynski, Olga Haus

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutati

Externí odkaz: https://doaj.org/article/4d3149eacd9c4e0bbd45e7fcb3834c44

IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen

Autor: Magdalena Zawada, Jerzy Holowiecki, Magdalena Wojtas, Sebastian Giebel, Agnieszka Przybylowicz, Anna Ejduk, I. Florek, Agnieszka Wierzbowska, Dariusz Kata, Kazimierz Kuliczkowski, Tomasz Wróbel, Beata Piatkowska-Jakubas, Przemysław Juszczynski, Marta Libura, Katarzyna Piwocka, Sylwia Czekalska, Marzena Wojtaszewska, Emilia Bialopiotrowicz, Karolina Matiakowska, Iwona Solarska, Tomasz Sacha, Patryk Gorniak, Tadeusz Robak, Elżbieta Urbanowska, Gail J. Roboz, Wiesław Wiktor Jędrzejczak, Agnieszka Sroka-Porada, Agnieszka Pluta, Wanda Knopinska, Justyna Gajkowska-Kulik, Krzysztof Warzocha, Anna Wróbel, Monika Paluszewska, Sebastian Grosicki, Karolina Karabin, Marta Pawelczyk, Bozena Jazwiec, Katarzyna Borg, Justyna Rybka, Grzegorz W. Basak, Olga Haus, Lidia Gil, Lukasz Bolkun, Agata Kominek, Grazyna Semenczuk, Agnieszka Piekarska, Krzysztof Lewandowski, Zoriana Salamanczuk, Karolina Pyziak, Katarzyna Wasilewska, Karolina Piechna, Monika Noyszewska-Kania

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9cde8aed54fc054fbe617df2b01f50
http://europepmc.org/articles/PMC8113255

International external quality assurance of JAK2 V617F quantification

Autor: Julia Asp, Marta Vorland, Anni Aggerholm, Lasse Kjær, Karl Haslam, Elisabeth Oppliger Leibundgut, Rajko Kusec, Karolina Matiakowska, Robert Kralovics, Frank Dicker, Alessandro Pancrazzi, Morten Andersen, Lars Palmqvist, Sylvie Hermouet, Margarida Coucelo, Bruno Cassinat, Filippo Navaglia, Andrey Sudarikov, Aleksandar Eftimov, Vibe Skov, Thomas Kielsgaard Kristensen, François Girodon, Laurence Lodé, Niels Pallisgaard, Eric Lippert, Jiri Schwarz, Marzena Wojtaszewska, Hajnalka Andrikovics, Guy Wayne Novotny, Dorota Link-Lenczowska, Susanna Akiki, Melanie J. Percy, Dina Naguib, Beatriz Bellosillo

Publikováno v: Asp, J, Skov, V, Bellosillo, B, Kristensen, T, Lippert, E, Dicker, F, Schwarz, J, Wojtaszewska, M, Palmqvist, L, Akiki, S, Aggerholm, A, Tolstrup Andersen, M, Girodon, F, Kjær, L, Oppliger Leibundgut, E, Pancrazzi, A, Vorland, M, Andrikovics, H, Kralovics, R, Cassinat, B, Coucelo, M, Eftimov, A, Haslam, K, Kusec, R, Link-Lenczowska, D, Lodé, L, Matiakowska, K, Naguib, D, Navaglia, F, Novotny, G W, Percy, M J, Sudarikov, A, Hermouet, S & Pallisgaard, N 2019, ' International external quality assurance of JAK2 V617F quantification ', Annals of Hematology, vol. 98, no. 5, pp. 1111-1118 . https://doi.org/10.1007/s00277-018-3570-8
Asp, Julia; Skov, Vibe; Bellosillo, Beatriz; Kristensen, Thomas; Lippert, Eric; Dicker, Frank; Schwarz, Jiri; Wojtaszewska, Marzena; Palmqvist, Lars; Akiki, Susanna; Aggerholm, Anni; Tolstrup Andersen, Morten; Girodon, François; Kjær, Lasse; Oppliger Leibundgut, Elisabeth; Pancrazzi, Alessandro; Vorland, Marta; Andrikovics, Hajnalka; Kralovics, Robert; Cassinat, Bruno; ... (2019). International external quality assurance of JAK2 V617F quantification. Annals of hematology, 98(5), pp. 1111-1118. Springer-Verlag 10.1007/s00277-018-3570-8
Annals of Hematology
Annals of Hematology, Springer Verlag, 2018, Epub ahead of print. ⟨10.1007/s00277-018-3570-8⟩
Annals of Hematology, 2018, Epub ahead of print. ⟨10.1007/s00277-018-3570-8⟩

IF 2.845; International audience; External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547ebdc885b6ccedd780ddbd89976b70
https://findresearcher.sdu.dk:8443/ws/files/150685801/International_external_quality_assurance_of_JAK2_V617F_quantification.pdf

Cladribine added to daunorubicin-cytarabine induction prolongs survival of FLT3-ITD+ normal karyotype AML patients

Autor: Sylwia Czekalska, Monika Paluszewska, Sebastian Grosicki, Sebastian Giebel, Iwona Solarska, Slawomira Kyrcz-Krzemien, Aleksander B. Skotnicki, Malgorzata Jakobczyk, Karolina Karabin, Katarzyna Borg, Karolina Matiakowska, Marek Kielbinski, Anna Ejduk, Wiesław Wiktor Jędrzejczak, Malgorzata Calbecka, Krzysztof Warzocha, Jerzy Holowiecki, I. Florek, Justyna Gajkowska-Kulik, Marta Pawelczyk, Bozena Jazwiec, Jolanta Libura, Beata Piatkowska-Jakubas, Magdalena Zawada, Olga Haus, Kazimierz Kuliczkowski, Grażyna Gadomska, Agnieszka Wierzbowska, Marta Libura, Dariusz Kata

To the editor: Internal tandem duplication in the FLT3 gene ( FLT3- ITD) has been recognized as a marker conferring poor outcome in patients with normal karyotype acute myeloid leukemia (NK-AML).[1][1] Because of the inferior outcome of FLT3- ITD+ NK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2cdba97bad8e63dd3d50ae39548812
https://ruj.uj.edu.pl/xmlui/handle/item/93427

CEBPA copy number variations in normal karyotype acute myeloid leukemia : possible role of breakpoint-associated microhomology and chromatin status in CEBPA mutagenesis

Autor: Aleksander B. Skotnicki, Karolina Karabin, Malgorzata Calbecka, Krzysztof Warzocha, Dariusz Kata, Sylwia Czekalska, Wiesław Wiktor Jęrzejczak, Marta Pawelczyk, Olga Haus, Ewa Duszenko, Grażyna Gadomska, Jolanta Libura, Katarzyna Borg, Justyna Gajkowska-Kulig, Z. Salamanczuk, I. Florek, Beata Piątkowska-Jakubas, Anna Ejduk, Magdalena Zawada, Malgorzata Jakobczyk, Bożena Jaźwiec, Barbara Mucha, Marek Kielbinski, Krystyna Soszyńska, Karolina Matiakowska, Sebastian Grosicki, Slawomira Kyrcz-Krzemien, Kazimierz Kuliczkowski, Marta Libura, Iwona Solarska

Copy number variations (CNV) in CEBPA locus represent heterogeneous group of mutations accompanying acute myeloid leukemia (AML). The aim of this study was to characterize different CEBPA mutation categories in regard to biological data like age, cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3f991ea6f8b295d69f2e1a82248fef
https://ruj.uj.edu.pl/xmlui/handle/item/136787