Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Karolina Drazkowska"'
Autor:
Mateusz Kozarski, Karolina Drazkowska, Marcelina Bednarczyk, Marcin Warminski, Jacek Jemielity, Joanna Kowalska
Publikováno v:
RSC Advances. 13:12809-12824
mRNA-based gene delivery is a powerful strategy for many therapeutic areas. In this work, we used CuAAC to synthesize next-generation triazole-bearing mRNA 5' cap analogs and evaluated them as reagents for modification of in vitro transcribed mRNA.
Autor:
Karolina Drazkowska, Rafal Tomecki, Marcin Warminski, Natalia Baran, Dominik Cysewski, Anaïs Depaix, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity, Pawel J Sikorski
In mammals, m7G-adjacent nucleotides undergo extensive modifications. Ribose of the first or first and second transcribed nucleotides can be subjected to 2′-O-methylation to form cap1 or cap2, respectively. When the first transcribed nucleotide is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f9024cc808077d108c88929ed5ad88
Autor:
Rafal Tomecki, Karolina Drazkowska
Publikováno v:
The FEBS Journal. 288:3418-3423
mRNA degradation rate is one of the key stages of gene expression regulation in eukaryotic cells. To date, intertwined processes of post-transcriptional control have been widely investigated, but focused rather on the examination of mechanisms contro
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Human innate cellular defence pathways have evolved to sense and eliminate pathogens, of which, viruses are considered one of the most dangerous. Their relatively simple structure makes the identification of viral invasion a difficult task for cells.
Autor:
Karolina Drazkowska, Natalia Baran, Marcin Warminski, Rafal Tomecki, Anaïs Depaix, Dominik Cysewski, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity, Pawel J. Sikorski
In higher eukaryotes, m7G-adjacent nucleotides undergo extensive modifications. Ribose of the first or first and second transcribed nucleotides can be subjected to 2’-O-methylation to form cap1 or cap2, respectively. Additionally, when the first tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8d9697d0ce4758f4cb347e6c713bed
https://doi.org/10.1101/2022.02.03.478939
https://doi.org/10.1101/2022.02.03.478939
Autor:
Andrzej Dziembowski, Karolina Drazkowska, Kamil Kobyłecki, Rafal Tomecki, Malwina Hyjek-Składanowska
Publikováno v:
RNA Biol
Despite the development of non-radioactive DNA/RNA labelling methods, radiolabelled nucleic acids are commonly used in studies focused on the determination of RNA fate. Nucleic acid fragments with radioactive nucleotide analoguesincorporated into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176b5209f5f76476049680d060f26b8f
Publikováno v:
Frontiers in Cellular Neuroscience
Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some cases, pathological events occur when a critical repeat length is reached. This phenomenon is observed in various neurological disorders, such as myotonic dystrop
Autor:
Rafal Tomecki, Roman J. Szczesny, Katarzyna Kalisiak, Ewelina P. Owczarek, Krystian Stodus, Jakub Gruchota, Iwo Kucinski, Andrzej Dziembowski, Karolina Drazkowska
Publikováno v:
Nucleic Acids Research
hDIS3 is a mainly nuclear, catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) active domains. Mutations in hDIS3 have been found in ∼10% of patients with multiple myeloma (MM). Here, we show th
Autor:
Andrzej Dziembowski, Torben Heick Jensen, Piotr P. Stepien, Katja M. Larsen, Jens S. Andersen, Karolina Drazkowska, Agnieszka Pastula, Maiken Søndergaard Kristiansen, Roman J. Szczesny, Søren Lykke-Andersen, Aleksander Chlebowski, Rafal Tomecki
Publikováno v:
Tomecki, R, Kristiansen, M S, Lykke-Andersen, S, Chlebowski, A, Larsen, K M, Szczesny, R J, Drazkowska, K, Pastula, A, Andersen, J S, Stepien, P P, Dziembowski, A & Jensen, T H 2010, ' The human core exosome interacts with differentially localized processive RNases : hDIS3 and hDIS3L ', E M B O Journal, vol. 29, no. 14, pp. 2342-57 . https://doi.org/10.1038/emboj.2010.121
The EMBO Journal; Vol 29
The EMBO Journal
The EMBO Journal; Vol 29
The EMBO Journal
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Sacch