Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Karolina A, Majorek"'
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Understanding the functions of metal ions in biological systems is crucial for many aspects of research, including deciphering their roles in diseases and potential therapeutic use. Structural information about the molecular or atomic details of thes
Externí odkaz:
https://doaj.org/article/450280e1c4d34759bd9eb61f29df6b44
Autor:
Ivan G. Shabalin, Mateusz P. Czub, Karolina A. Majorek, Dariusz Brzezinski, Marek Grabowski, David R. Cooper, Mateusz Panasiuk, Maksymilian Chruszcz, Wladek Minor
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1048-1058 (2020)
Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by bindi
Externí odkaz:
https://doaj.org/article/e7a02ff430e24c52a9d34bcb4f2f01c9
Autor:
Jackson T. Baumgartner, Thahani S. Habeeb Mohammad, Mateusz P. Czub, Karolina A. Majorek, Xhulio Arolli, Cillian Variot, Madison Anonick, Wladek Minor, Miguel A. Ballicora, Daniel P. Becker, Misty L. Kuhn
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Enzymes in the Gcn5-related N-acetyltransferase (GNAT) superfamily are widespread and critically involved in multiple cellular processes ranging from antibiotic resistance to histone modification. While acetyl transfer is the most widely catalyzed re
Externí odkaz:
https://doaj.org/article/74316e09531b4a3c8e463bec590281bb
Autor:
Mark A. Nakasone, Karolina A. Majorek, Mads Gabrielsen, Gary J. Sibbet, Brian O. Smith, Danny T. Huang
Publikováno v:
Nature Chemical Biology. 18:422-431
Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis remains elusive due to the transient nature of Ub handover. Here, we pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b00b065e84f7df0c09e6f054c06098
https://doi.org/10.1038/s41589-021-00952-x
https://doi.org/10.1038/s41589-021-00952-x
Autor:
Matthew D. Zimmerman, Heping Zheng, Wladek Minor, Ivan G. Shabalin, Karolina A. Majorek, Marek Grabowski
Publikováno v:
Structural Biology in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd8f11fb548ad3b108459497b2db23e
https://doi.org/10.1002/9781118681121.ch11
https://doi.org/10.1002/9781118681121.ch11
Autor:
Katarzyna B. Handing, Mateusz P. Czub, Kyungah Suh, Barat S. Venkataramany, Ivan G. Shabalin, Karolina A. Majorek, Przemyslaw J. Porebski, Wladek Minor, Ashley G. Woolfork, Sandya R. Beeram, David S. Hage
Publikováno v:
Chemical Science. 10:1607-1618
Serum albumin is the most abundant protein in mammalian blood plasma and is responsible for the transport of metals, drugs, and various metabolites, including hormones. We report the first albumin structure in complex with testosterone, the primary m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::533afb20062765a9542819b82ebe33f8
https://doi.org/10.1039/c8sc04397c
https://doi.org/10.1039/c8sc04397c
Autor:
Mark A, Nakasone, Karolina A, Majorek, Mads, Gabrielsen, Gary J, Sibbet, Brian O, Smith, Danny T, Huang
Publikováno v:
Nature chemical biology. 18(4)
Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis remains elusive due to the transient nature of Ub handover. Here, we pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a423c870b00a52268d7ef3f5190bcd0f
https://pubmed.ncbi.nlm.nih.gov/35027744
https://pubmed.ncbi.nlm.nih.gov/35027744
Autor:
Jackson T, Baumgartner, Thahani S, Habeeb Mohammad, Mateusz P, Czub, Karolina A, Majorek, Xhulio, Arolli, Cillian, Variot, Madison, Anonick, Wladek, Minor, Miguel A, Ballicora, Daniel P, Becker, Misty L, Kuhn
Publikováno v:
Frontiers in Molecular Biosciences
Enzymes in the Gcn5-related N-acetyltransferase (GNAT) superfamily are widespread and critically involved in multiple cellular processes ranging from antibiotic resistance to histone modification. While acetyl transfer is the most widely catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0c975f68fbe623727c1e7cbcf97d7ec
https://pubmed.ncbi.nlm.nih.gov/33912589
https://pubmed.ncbi.nlm.nih.gov/33912589
Autor:
Karolina A. Majorek, Marek Grabowski, David R. Cooper, Dariusz Brzezinski, Mateusz Panasiuk, Ivan G. Shabalin, Mateusz P. Czub, Maksymilian Chruszcz, Wladek Minor
Publikováno v:
IUCrJ
bioRxiv
article-version (status) pre
article-version (number) 1
IUCrJ, Vol 7, Iss 6, Pp 1048-1058 (2020)
bioRxiv
article-version (status) pre
article-version (number) 1
IUCrJ, Vol 7, Iss 6, Pp 1048-1058 (2020)
The structure of serum albumin in complex with dexamethasone reveals why the drug may not always help COVID-19 patients.
Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances o
Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1608011693e2ad4e49fbdfb0110b6135
Autor:
Karolina A. Majorek, Tyler E. Sheahan, Anna Gawlicka-Chruszcz, Maksymilian Chruszcz, Sarah E. Pye, S.S. Pote
Publikováno v:
Biochemical and Biophysical Research Communications. 503:1993-1999
Neisseria gonorrhoeae, an obligate human pathogen, is a leading cause of communicable diseases globally. Due to rapid development of drug resistance, the rate of successfully curing gonococcal infections is rapidly decreasing. Hence, research is bein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c226b141ebf3200cf4bc9251f6a28bec
https://doi.org/10.1016/j.bbrc.2018.07.147
https://doi.org/10.1016/j.bbrc.2018.07.147