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pro vyhledávání: '"Karolina Wosik"'
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Autor:
Alexandre Prat, Monique Bernard, Robert Moumdjian, T. L. Reudelhuber, Karolina Wosik, F. Berthelet, Alain Bouthillier, Aurore Dodelet-Devillers, Romain Cayrol
Publikováno v:
The Journal of Neuroscience. 27:9032-9042
The blood–brain barrier (BBB) restricts molecular and cellular trafficking between the blood and the CNS. Although astrocytes are known to control BBB permeability, the molecular determinants of this effect remain unknown. We show that angiotensino
Autor:
Reina Bendayan, Alexandre Prat, Karlo Babakhanian, Karolina Wosik, Gloria Lee, Manisha Ramaswamy
Publikováno v:
Pharmaceutical Research. 24:1262-1274
The function of ABCG2 (BCRP), a member of the ATP-binding cassette (ABC) superfamily of membrane-associated drug transporters, at the blood-brain barrier remains highly controversial. This project investigates the functional expression of endogenous
Autor:
Alain Bouthillier, Hania Kebir, Alexandre Prat, Pierre Duquette, Chantale Auger, Monique Bernard, Robert Moumdjian, Igal Ifergan, Romain Cayrol, Karolina Wosik
Publikováno v:
Annals of Neurology. 60:45-55
Objective Dysregulation of the blood–brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes partaking in lesion formation in both multiple sclerosis (MS) and its early clinical form,
Autor:
Francesca Ruffini, Guillermina Almazan, André Olivier, Josephine Nalbantoglu, Jack P. Antel, Karolina Wosik
Publikováno v:
Brain. 127:2636-2648
Multiple sclerosis is an inflammatory disease of the CNS leading to the destruction of oligodendrocytes (OLs), myelin sheaths and axons. The mediators of tissue injury remain unknown. Glutamate, which can be released by activated immune cells or prod
Autor:
Karolina Wosik, Wolfgang Brück, Tanja Kuhlmann, Jack P. Antel, Bernard Massie, Josephine Nalbantoglu
Publikováno v:
Journal of Neurochemistry. 85:635-644
Multiple sclerosis (MS) is a neurological disorder characterized by myelin destruction and a variable degree of oligodendrocyte death. We have previously shown that overexpression of the transcription factor p53 can induce oligodendrocyte apoptosis.
Autor:
Alexandre Prat, Karolina Wosik, Amit Bar-Or, Ellie McCrea, Katarzyna Biernacki, Ho Jin Kim, Jack P. Antel, Rosanne Seguin, Manon Blain
Publikováno v:
Glia. 42:36-45
We assessed the effects of soluble molecules (supernatants) produced by pro- (Th1) and anti- (Th2) inflammatory T-cell lines on the capacity of adult human CNS-derived microglia to express or produce selected cell surface and soluble molecules that r
Autor:
Karolina Wosik, Alexandre Prat, Jack P. Antel, Zacharo Moditi, Katarzyna Biernacki, Rosanne Seguin, Ronny L. Rotondo
Publikováno v:
Journal of Neuroimmunology. 135:96-106
Blood-derived monocytic cells comprise a significant component of most inflammatory responses that occur in the CNS. We utilized human brain-derived endothelial cells (HBECs) coated membranes in Boyden chambers to assess immune function related prope
Autor:
Kenneth Aldape, Jeanne M. Soos, Scott S. Zamvil, Karolina Wosik, Jeffrey I. Krieger, Anthony J. Slavin, Patricia A. Nelson, Chelsea L. King, Jack P. Antel, Juan C. Patarroyo, Olaf Stüve
Publikováno v:
Glia. 36:391-405
Malignant gliomas (MGs), lethal human central nervous system (CNS) neoplasms, contain tumor infiltrating lymphocytes (TIL). Although MHC class II molecules are frequently detected on MG cells, suggesting that they may be capable of antigen (Ag) prese
Publikováno v:
Glia. 36:145-155
The blood-brain barrier (BBB) is a specialized structure of the central nervous system (CNS) that restricts immune cell migration and soluble molecule diffusion from the systemic compartment into the CNS. Astrocytes and microglia are resident cells o