Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Karolina, Wydra"'
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
Anxiety and depression are the most common mental disorders affecting people worldwide. Recent studies have highlighted that a maternal high-sugar diet (HSD) could be a risk factor for neurobehavioural dysregulations, including mood disorders. Increa
Externí odkaz:
https://doaj.org/article/4671ffa3a0874aabbb8f984b452ac813
Autor:
Dasiel O. Borroto-Escuela, Alexander Lopez-Salas, Karolina Wydra, Marco Bartolini, Zilong Zhou, Malgorzata Frankowska, Agata Suder, Javier Benitez-Porres, Wilber Romero-Fernandez, Malgorzata Filip, Kjell Fuxe
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes foll
Externí odkaz:
https://doaj.org/article/a51533e3ab2b4ca094a860cf75cf665a
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1411 (2023)
Background: Cocaine use disorder (CUD) is a relapsing brain disease caused by a chronic drug intake that involves neural mechanisms and psychological processes, including depression. Preclinical and clinical studies have demonstrated the promise of p
Externí odkaz:
https://doaj.org/article/e7ffba9609d54cb1808cdf08af64f378
Autor:
Małgorzata Frankowska, Karolina Wydra, Agata Suder, Magdalena Zaniewska, Dawid Gawliński, Joanna Miszkiel, Anna Furgała-Wojas, Kinga Sałat, Małgorzata Filip, Christa E. Müller, Katarzyna Kieć-Kononowicz, Magdalena Kotańska
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9046 (2023)
The lack of selective pharmacological tools has limited the full unraveling of G protein-coupled receptor 18 (GPR18) functions. The present study was aimed at discovering the activities of three novel preferential or selective GPR18 ligands, one agon
Externí odkaz:
https://doaj.org/article/4d952f28f5f14686af719815d48449b3
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1449 (2023)
Obesity is a substantial health and economic issue, and serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter system involved in the regulation of body weight. The 5-HT2C receptors (5-HT2CRs), one of 16 of the 5-HT receptor (5-HTRs)
Externí odkaz:
https://doaj.org/article/55c9f8e9106e43d4b2354fb24438a2ff
Autor:
Pawel Grochecki, Irena Smaga, Karolina Wydra, Marta Marszalek-Grabska, Tymoteusz Slowik, Ewa Kedzierska, Joanna Listos, Ewa Gibula-Tarlowska, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1941 (2023)
Treatment of Post-Traumatic Stress Disorder (PTSD) is complicated by the presence of drug use disorder comorbidity. Here, we examine whether conditioned fear (PTSD model) modifies the rewarding effect of mephedrone and if repeated mephedrone injectio
Externí odkaz:
https://doaj.org/article/cceac333be8e4ac58a13e6b89c67aff8
Publikováno v:
Nutrients, Vol 14, Iss 14, p 2940 (2022)
Carbohydrates are important macronutrients in human and rodent diet patterns that play a key role in crucial metabolic pathways and provide the necessary energy for proper body functioning. Sugar homeostasis and intake require complex hormonal and ne
Externí odkaz:
https://doaj.org/article/ab2029dbab944f60aa5d64f73a9c6459
Autor:
Dasiel O. Borroto-Escuela, Karolina Wydra, Ramon Fores-Pons, Lakshmi Vasudevan, Wilber Romero-Fernandez, Małgorzata Frankowska, Luca Ferraro, Sarah Beggiato, Minerva Crespo-Ramirez, Alicia Rivera, Luisa L. Rocha, Miguel Perez de la Mora, Christophe Stove, Małgorzata Filip, Kjell Fuxe
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was proposed that they form the
Externí odkaz:
https://doaj.org/article/ee239dc1e6db4c2a94875c5d1f855455
Autor:
Irena Smaga, Karolina Wydra, Małgorzata Frankowska, Fabio Fumagalli, Marek Sanak, Małgorzata Filip
Publikováno v:
Molecules, Vol 25, Iss 15, p 3480 (2020)
Cocaine-induced plasticity in the glutamatergic transmission and its N-methyl-d-aspartate (NMDA) receptors are critically involved in the development of substance use disorder. The presynaptic active zone proteins control structural synaptic plastici
Externí odkaz:
https://doaj.org/article/9146288a891348dd9a0713574821d857
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 654 (2020)
Research demonstrates that adolescents differ from adults in their response to drugs of abuse. The aim of the present study was to examine the influence of ethanol, Δ9-tetrahydrocannabinol hydrochloride (THC), and a combination of these drugs given
Externí odkaz:
https://doaj.org/article/035823ad344b47bc81d2ccaabaa30b45