Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Karolin Wellner"'
Autor:
Raphaël de Wijn, Kévin Rollet, Felix G.M. Ernst, Karolin Wellner, Heike Betat, Mario Mörl, Claude Sauter
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5845-5855 (2021)
CCA-adding enzymes are highly specific RNA polymerases that add and maintain the sequence C-C-A at tRNA 3‘-ends. Recently, we could reveal that cold adaptation of such a polymerase is not only achieved at the expense of enzyme stability, but also a
Externí odkaz:
https://doaj.org/article/483aeb0567bc4cec89987f2a9e1502ba
Autor:
Tim Kolberg, Sarah von Löhneysen, Iuliia Ozerova, Karolin Wellner, Roland K Hartmann, Peter F Stadler, Mario Mörl
Publikováno v:
Nucleic Acids Research.
Structural analysis of RNA is an important and versatile tool to investigate the function of this type of molecules in the cell as well as in vitro. Several robust and reliable procedures are available, relying on chemical modification inducing RT st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c57a0a23c90399b11f227df29d0aff
https://doi.org/10.1093/nar/gkad312
https://doi.org/10.1093/nar/gkad312
Autor:
Martina Hager, Marie-Theres Pöhler, Franziska Reinhardt, Karolin Wellner, Jessica Hübner, Heike Betat, Sonja Prohaska, Mario Mörl
Publikováno v:
Molecular Biology and Evolution. 39
In tRNA maturation, CCA-addition by tRNA nucleotidyltransferase is a unique and highly accurate reaction. While the mechanism of nucleotide selection and polymerization is well understood, it remains a mystery why bacterial and eukaryotic enzymes exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea9cc4f9d37c756b1f8d8db1c62cce7
https://doi.org/10.1093/molbev/msac250
https://doi.org/10.1093/molbev/msac250
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:433-441
tRNAs are key players in translation and are additionally involved in a wide range of distinct cellular processes. The vital importance of tRNAs becomes evident in numerous diseases that are linked to defective tRNA molecules. It is therefore not sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651cf1209eaa125d6df06ed28e3cf5fa
https://doi.org/10.1016/j.bbagrm.2018.01.012
https://doi.org/10.1016/j.bbagrm.2018.01.012
Examining tRNA 3′-ends in Escherichia coli: teamwork between CCA-adding enzyme, RNase T, and RNase R
tRNA maturation and quality control are crucial for proper functioning of these transcripts in translation. In several organisms, defective tRNAs were shown to be tagged by poly(A) or CCACCA tails and subsequently degraded by 3′-exonucleases. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58f9ec95264ad3ad10a08e0a2a1b4b3
https://europepmc.org/articles/PMC5824355/
https://europepmc.org/articles/PMC5824355/
