Výsledky vyhledávání - "Karolien Van Rompaey"

Synthesis and Evaluation of the β-Turn Properties of 4-Amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones and of Their Spirocyclic Derivative

Autor: Kenno Vanommeslaeghe, Csaba Tömböly, Dirk Tourwé, Steven Ballet, Karolien Van Rompaey, Monique Biesemans, Rien De Wachter, Rudolph Willem

Publikováno v: European Journal of Organic Chemistry. 2006:2899-2911

A series of 4-amino-tetrahydro-2-benzazepin-3-one derivatives (Ac–Aba–Xxx–NHMe) were prepared as tetrapeptide mimetics. Considering the structural resemblance with the so-called Freidinger lactams, their propensity to adopt a β-turn conformati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20fd5e58dc38bc6f5de0f3fc262db269
https://doi.org/10.1002/ejoc.200500996

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Solid-Supported Solution-Phase Synthesis of 4-Amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones

Autor: Dirk Tourwé, Karolien Van Rompaey, and Francesco Lazzaro, Isabelle Van den Eynde

Publikováno v: Journal of Combinatorial Chemistry. 6:468-473

Starting from Boc-o-aminomethylphenylalanine, a solution-phase parallel synthesis of 2,4-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. This heterocycle has two nitrogen functions, which are differentiated and can be select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd7d0c964da9e884f93d383fc425504
https://doi.org/10.1021/cc049940w

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Cushing's disease: diagnosis throught the nose. A case report

Autor: David Unuane, Haens, Jean D., Karolien Van Rompaey, Stijn Halewyck, Kris Poppe, Brigitte Velkeniers

Publikováno v: Vrije Universiteit Brussel

In Cushing's disease clinical symptoms are usually related to the ACTH hypersecretion. On diagnosis these secretions tumours tend to be small due to their ability to reach clinical detection early. However, symptoms may also be caused by mass-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::339df942a9ffd1634f4868494d1198d5
https://biblio.vub.ac.be/vubir/cushings-disease-diagnosis-throught-the-nose-a-case-report(5b0a077c-a3d1-45e4-8822-e46f6e6d20fe).html

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High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics

Autor: Antal Péter, István Ilisz, Karolien Van Rompaey, Rien De Wachter, Dirk Tourwé, Steven Ballet, Daniel W. Armstrong

Publikováno v: Journal of separation science. 30(12)

The stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics were separated on macrocyclic glycopeptide and cellulose-based chiral stationary phases (CSPs) in the RP and polar-ionic modes. The effects of the organic modifier, the mobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc746fb68c54b5127b44aaf923daa0
https://pubmed.ncbi.nlm.nih.gov/17638345

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Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold

Autor: Dagmara Tymecka, Minying Cai, Alexander V. Mayorov, Aleksandra Misicka, Steven Ballet, Dirk Tourwé, Karolien Van Rompaey, Erin S. Palmer, Kevin B. Chandler, Victor J. Hruby

Publikováno v: Bioorganicmedicinal chemistry letters. 17(9)

In search of new selective antagonists and/or agonists for the human melanocortin receptor subtypes hMC1R to hMC5R to elucidate the specific biological roles of each GPCR, we modified the structures of the superagonist MT-II (Ac-Nle-c[Asp-His-D-Phe-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631bcf1b6ffafafec792cf95ef5fc833
https://pubmed.ncbi.nlm.nih.gov/17314042

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A Versatile Synthesis of 2-Substituted 4-Amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones

Autor: Dirk Tourwé, Norbert De Kimpe, Isabelle Van den Eynde, Karolien Van Rompaey

Publikováno v: ChemInform. 34

A mild and general strategy for the synthesis of 2-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. The seven-membered lactam is prepared by intramolecular amide bond formation from the intermediate amino acid, which is obtai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad174bc35a99d7972007f6ffcfb52517
https://doi.org/10.1002/chin.200339149

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