The Immunological Profile of Adipose Mesenchymal Stromal/Stem Cells after Cell Expansion and Inflammatory Priming

Autor: Karolien Buyl, Makram Merimi, Robim M. Rodrigues, Saida Rahmani, Mohammad Fayyad-Kazan, Fatima Bouhtit, Noureddine Boukhatem, Tamara Vanhaecke, Hassan Fahmi, Joery De Kock, Mehdi Najar

Publikováno v: Biomolecules, Vol 14, Iss 7, p 852 (2024)

Background: AT-MSCs display great immunoregulatory features, making them potential candidates for cell-based therapy. This study aimed to evaluate the “RBC lysis buffer” isolation protocol and immunological profiling of the so-obtained AT-MSCs. M

Externí odkaz: https://doaj.org/article/ef1210ad818c4be8bbd3a1ff36e37c92

From NAFLD to MAFLD: Aligning Translational In Vitro Research to Clinical Insights

Autor: Alexandra Gatzios, Matthias Rombaut, Karolien Buyl, Joery De Kock, Robim M. Rodrigues, Vera Rogiers, Tamara Vanhaecke, Joost Boeckmans

Publikováno v: Biomedicines, Vol 10, Iss 1, p 161 (2022)

Although most same-stage non-alcoholic fatty liver disease (NAFLD) patients exhibit similar histologic sequelae, the underlying mechanisms appear to be highly heterogeneous. Therefore, it was recently proposed to redefine NAFLD to metabolic dysfuncti

Externí odkaz: https://doaj.org/article/8a638736073742fd8a15086fda9c252f

Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor

Autor: Joost Boeckmans, Karolien Buyl, Alessandra Natale, Valerie Vandenbempt, Steven Branson, Veerle De Boe, Vera Rogiers, Joery De Kock, Robim M. Rodrigues, Tamara Vanhaecke

Publikováno v: Data in Brief, Vol 25, Iss , Pp - (2019)

The present dataset contains the transcriptomic characterization of a novel in vitro model of non-alcoholic steatohepatitis (NASH) as well as its transcriptomics read-outs for the evaluation of elafibranor, a potential anti-NASH compound. We report w

Externí odkaz: https://doaj.org/article/cdfa3a1f73eb444eb5aa1427c40d706b

Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

Autor: Vera Rogiers, Anja Heymans, Joost Boeckmans, Veerle De Boe, Matthias Rombaut, Joery De Kock, Tamara Vanhaecke, Alessandra Natale, Brent Cami, Robim Marcelino Rodrigues, Karolien Buyl

Publikováno v: Cell Biology and Toxicology. 37:293-311

Non-alcoholic steatohepatitis (NASH) is a highly prevalent, chronic liver disease characterized by hepatic lipid accumulation, inflammation, and concomitant fibrosis. Up to date, no anti-NASH drugs have been approved. In this study, we reproduced key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df274c7e0e1fe89ca71333141a57281a
https://doi.org/10.1007/s10565-020-09544-2

Transcriptional profile of cytokines, regulatory mediators and tlr in mesenchymal stromal cells after inflammatory signaling and cell-passaging

Autor: Robim Marcelino Rodrigues, Makram Merimi, Vera Rogiers, Philippe Lewalle, Laurence Lagneaux, Dhouha Daassi, Rahma Melki, Karolien Buyl, Hassan Fahmi, Mehdi Najar, Joery De Kock, Tamara Vanhaecke

Publikováno v: International journal of molecular sciences, 22 (14
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7309, p 7309 (2021)

Adult human subcutaneous adipose tissue (AT) harbors a rich population of mesenchymal stromal cells (MSCs) that are of interest for tissue repair. For this purpose, it is of utmost importance to determine the response of AT-MSCs to proliferative and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d18997972040e04c455d4d25438cdc
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/329221