Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Karola Köhler"'
Publikováno v:
European Journal of Paediatric Neurology. 11:10-16
Introduction Epilepsy is very frequent in Rett syndrome (RTT) patients and often difficult to treat. Because most cases of RTT are caused by mutations in the MECP2 gene it is reasonable to assume that convulsions are based on common pathogenetic mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e7f5c71f1c3c131dd506afa4d9b403
https://doi.org/10.1016/j.ejpn.2006.09.003
https://doi.org/10.1016/j.ejpn.2006.09.003
Publikováno v:
The Journal of Pediatrics. 142:332-335
Objective We reevaluated 49 girls with either Rett syndrome (RTT) or features of RTT who had negative test results for mutations in the MECP2 gene and compared them with 49 girls who had positive test results. The girls with MECP2-positive results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489656a005755a90ff5a91265877c87f
https://doi.org/10.1067/mpd.2003.96
https://doi.org/10.1067/mpd.2003.96
Autor:
Jan Lüdemann, Max P. Baur, Stefan Schreiber, Thomas Meitinger, Andreas Ziegler, Rainer Vogler, Thomas Bettecken, Claudia Lamina, Peter Lichtner, Amke Caliebe, Norman Klopp, Kathryn Roeder, Jochen Hampe, Michael Krawczak, Thomas Illig, Michael Steffens, Rolf Fimmers, Amalia Diaz Lacava, Inke R. König, Karola Köhler, Eun-Kyung Suk, Peter Nürnberg, Mohammad R. Toliat, H.-Erich Wichmann, Thomas F. Wienker, Andreas Wolf, Patricia Entz
Publikováno v:
Hum. Hered. 62, 20-29 (2006)
Objective: To evaluate the relevance and necessity to account for the effects of population substructure on association studies under a case-control design in central Europe, we analysed three samples drawn from different geographic areas of Germany.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd410271904226acdd084e2a83c0953
https://pubmed.ncbi.nlm.nih.gov/17003564
https://pubmed.ncbi.nlm.nih.gov/17003564
Autor:
Bettina Kulle, Albert Rosenberger, Heike Bickeböller, Nico Janicke, Karola Köhler, Katrin Korb
Publikováno v:
BMC Genetics
For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d5cf74520dfddff742203ca8a381f
https://doi.org/10.1186/1471-2156-6-s1-s55
https://doi.org/10.1186/1471-2156-6-s1-s55
Publikováno v:
BMC Genetics
BMC Genetics, Vol 4, Iss Suppl 1, p S85 (2003)
BMC Genetics, Vol 4, Iss Suppl 1, p S85 (2003)
Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal data on independent sib pairs, modelling the phenotypic quadrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe34293d41d63be4e8d604a64efb5d9
http://resolver.sub.uni-goettingen.de/purl?goescholar/1248
http://resolver.sub.uni-goettingen.de/purl?goescholar/1248
Autor:
J. Gabrielle Granda, Hesham M. Amin, Razelle Kurzrock, Hongxia Zheng, Friedhelm Bladt, Manfred B. Klevesath, Siqing Fu, Gerald S. Falchook, Sarina Anne Piha-Paul, Filip Janku, Andreas Johne, David S. Hong, Karola Köhler
Publikováno v:
Cancer Research. 74:CT236-CT236
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Introduction: Overexpression of the c-Met oncoprotein can enhance invasive tumor behavior and is correlated with poor prognosis. MSC2156119J, a highly selective, ATP-competitive, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28f838f9b2fa38efaab6c956d4dc751
https://doi.org/10.1158/1538-7445.am2014-ct236
https://doi.org/10.1158/1538-7445.am2014-ct236
Autor:
Siqing Fu, J. Gabrielle Granda, Sarina Anne Piha-Paul, Filip Janku, Manfred B. Klevesath, Gerald S. Falchook, Andreas Johne, David S. Hong, Razelle Kurzrock, Hesham M. Amin, Friedhelm Bladt, Hongxia Zheng, Karola Köhler
Publikováno v:
Journal of Clinical Oncology. 32:2521-2521
2521^ Background: MSC2156119J, a selective c-Met inhibitor, suppresses tumor growth in preclinical models. Methods: Primary endpoint of this dose-escalation study (3+3 design; NCT01014936): to asse...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b3c0163bf3a51f897420d66ae5e77b
https://doi.org/10.1200/jco.2014.32.15_suppl.2521
https://doi.org/10.1200/jco.2014.32.15_suppl.2521
Autor:
Manfred B. Klevesath, Aung Naing, David S. Hong, Jennifer J. Wheler, Friedhelm Bladt, Siqing Fu, Hesham M. Amin, Sarina Anne Piha-Paul, Vivek Subbiah, Razelle Kurzrock, Andreas Johne, Filip Janku, Karola Köhler, Gerald S. Falchook
Publikováno v:
Journal of Clinical Oncology. 31:2506-2506
2506^ Background: To perform the first-in-human study of EMD 1214063, a highly selective, reversible, ATP-competitive c-Met inhibitor that causes growth inhibition and regression of hepatocyte growth factor-dependent and -independent tumors in precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d6067f2da6e886896126eb4499ca717
https://doi.org/10.1200/jco.2013.31.15_suppl.2506
https://doi.org/10.1200/jco.2013.31.15_suppl.2506
Publikováno v:
BMC Proceedings
ResearcherID
BMC Proceedings, Vol 1, Iss Suppl 1, p S29 (2007)
ResearcherID
BMC Proceedings, Vol 1, Iss Suppl 1, p S29 (2007)
Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a framework to test for association in a case-control design inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9548754bdb03cdd52ccb336747698771