Data from Target Sequence Accessibility Limits Activation-Induced Cytidine Deaminase Activity in Primary Mediastinal B-Cell Lymphoma

Autor: Frank Leithäuser, Peter Möller, Olga Ritz, Karola Dorsch, Thomas F. Barth, Silke Brüderlein, Beate Wotschke, Gerhard Moldenhauer, Sergey W. Popov

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies. For unknown reasons, B-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9757f84fd1c0a19404982308b8b51d2a
https://doi.org/10.1158/0008-5472.c.6494784.v1

A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells

Autor: Ralf Marienfeld, Silke Brüderlein, Karola Dorsch, Peter Möller, Malena Zahn, Anna Mießner, S Wegener, Thomas F. E. Barth, Benjamin Renner, Janine Heinrich, Ingo Melzner

Publikováno v: Blood. 129(11)

Chronic activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways is a hallmark of a variety of B-cell lymphomas, including classical Hodgkin lymphoma (cHL). Constitutive JAK/STAT signaling is cru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e202ff951c53cbdbd0154a9635a4f6
https://pubmed.ncbi.nlm.nih.gov/28082443

Report: workshop on mediastinal grey zone lymphoma

Autor: Sibrand Poppema, Ingo Melzner, Anke van den Berg, Hetty Lammert, Peter Möller, Gustavo Stolovitzky, Alexandra J. Bucur, Cigdem Atayar, Stephan Joos, Uwe Klein, Andrea Califano, T. F. E. Barth, Dido Lenze, Yuhai Tu, Antonino Carbone, Giorgio Cattoretti, Annunziata Gloghini, Martin J. S. Dyer, Karola Dorsch, Thomas F. E. Barth, Peter Lichter, Silke Brüderlein, Cornelia Hasel, Ricardo Dalla-Favera, Harald Stein, Frank Leithäuser, Andreas Rosenwald, Michael Hummel, Joost Kluiver

Publikováno v: European Journal of Haematology. 75:45-52

There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d7da96b9f9ffe70474f2208530316b5
https://doi.org/10.1111/j.1600-0609.2005.00454.x

Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.: STAT6 mutations in mediastinal B-cell lymphoma

Autor: Philippe Gaulard, Chrystelle Guiter, Julia Melzner, Gwendoline Dubois, Jean-Philippe Jais, Karola Dorsch, Peter Møller, Olga Ritz, Karen Leroy, Flavia Castellano

Publikováno v: Blood
Blood, American Society of Hematology, 2009, 114 (6), pp.1236-42. ⟨10.1182/blood-2009-03-209759⟩
Blood, American Society of Hematology, 2009, 114 (6), pp.1236-42. 〈10.1182/blood-2009-03-209759〉

Primary mediastinal B-cell lymphoma (PMBL) is a separate entity of aggressive B-cell lymphoma, characterized by a constitutive activation of janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, also observed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1e6f7c25d56f344c58a0bf5ce86a63
https://pubmed.ncbi.nlm.nih.gov/19661272

Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma

Autor: Olga Ritz, Silke Brüderlein, Beate Wotschke, Frank Leithäuser, Sergey Popov, Karola Dorsch, Peter Möller, Thomas F. E. Barth, Gerhard Moldenhauer

Publikováno v: Cancer research. 67(14)

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies. For unknown reasons, B-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634377382d9777d43558f917c790996e
https://pubmed.ncbi.nlm.nih.gov/17638864