Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karol Wtorek"'
Autor:
Justyna Piekielna-Ciesielska, Davide Malfacini, Francine Medjiofack Djeujo, Chantal Marconato, Karol Wtorek, Girolamo Calo’, Anna Janecka
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The mu opioid receptor agonists are the most efficacious pain controlling agents but their use is accompanied by severe side effects. More recent developments indicate that some ligands can differentially activate receptor downstream pathways, possib
Externí odkaz:
https://doaj.org/article/f4a1f2d1899345fa81adb58a5b44cd70
Autor:
Karol Wtorek, Alessia Ghidini, Luca Gentilucci, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Chiara Ruzza, Chiara Sturaro, Girolamo Calò, Stefano Pieretti, Alicja Kluczyk, John McDonald, David G. Lambert, Anna Janecka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12700 (2022)
Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-
Externí odkaz:
https://doaj.org/article/819627af45404fe79afa47b69584b618
Autor:
Karol Wtorek, Piotr F. J. Lipiński, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Jarosław Sukiennik, Alicja Kluczyk, Anna Janecka
Publikováno v:
Molecules, Vol 27, Iss 1, p 151 (2021)
Our formerly described pentapeptide opioid analog Tyr-c[D-Lys-Phe-Phe-Asp]NH2 (designated RP-170), showing high affinity for the mu (MOR) and kappa (KOR) opioid receptors, was much more stable than endomorphine-2 (EM-2) in the rat brain homogenate an
Externí odkaz:
https://doaj.org/article/c146faeb9cb8454185fcfe4226b71699
Autor:
Arijit Sarkar, Anna Adamska-Bartlomiejczyk, Justyna Piekielna-Ciesielska, Karol Wtorek, Alicja Kluczyk, Attila Borics, Anna Janecka
Publikováno v:
Molecules, Vol 25, Iss 18, p 4260 (2020)
The opioid receptors are members of the G-protein-coupled receptor (GPCR) family and are known to modulate a variety of biological functions, including pain perception. Despite considerable advances, the mechanisms by which opioid agonists and antago
Externí odkaz:
https://doaj.org/article/36a33d08b5164cf9a54047a9b6252a2e
Publikováno v:
Postępy Higieny i Medycyny Doświadczalnej. 72:1073-1083
Drug resistance is a well-known phenomenon that occurs when initially responsive to chemotherapy cancer cells become tolerant and elude further effectiveness of anticancer drugs. Based on their mechanism of action, anticancer drugs can be divided int
Autor:
Karol Wtorek, Anna Janecka
Publikováno v:
Chemistrybiodiversity. 18(1)
Nociceptin receptor (NOP) belongs to the family of opioid receptors but was discovered and characterized much later than the so called classical opioid receptors, μ, δ and κ (or MOP, DOP and KOP, resp.). Nociceptin/orphanin FQ (N/OFQ) is the endog
Publikováno v:
Peptides. 130
Reducing the well-known side effects of opioids prescribed to treat chronic pain remains unresolved, despite extensive research in this field. Among several options to tackle this problem the synthesis of multifunctional compounds containing hybridiz
Autor:
Girolamo Calo, Anna Janecka, Joanna Piasecka-Zelga, Karol Wtorek, Justyna Piekielna-Ciesielska, Katarzyna Gach-Janczak, Anna Adamska-Bartłomiejczyk, Agata Szymaszkiewicz, Federica Ferrari
Publikováno v:
Peptides. 105:51-57
Morphine and related drugs, which are the most effective analgesics for the relief of severe pain, act through activating opioid receptors. The endogenous ligands of these receptors are opioid peptides which cannot be used as antinociceptive agents d
Autor:
Anna Janecka, Alicja Kluczyk, Karol Wtorek, Justyna Piekielna-Ciesielska, Luca Gentilucci, Jacek Koszuk, Roberto Artali
Publikováno v:
European journal of medicinal chemistry. 179
New analogs of the endogenous opioid agonist endomorphin-2 (EM-2, H-Tyr-Pro-Phe-Phe-NH2) have been obtained by introducing modified tyrosines at the position 1 of the sequence. For all analogs, the cis/trans conformation ratio about the tyramine-Pro
Autor:
Anna Janecka, Girolamo Calo, Joanna Piasecka-Zelga, Chiara Ruzza, Federica Ferrari, Alicja Kluczyk, Justyna Piekielna-Ciesielska, Karol Wtorek, Anna Adamska-Bartłomiejczyk
Publikováno v:
Molecules
Volume 24
Issue 24
Volume 24
Issue 24
Morphine, which acts through opioid receptors, is one of the most efficient analgesics for the alleviation of severe pain. However, its usefulness is limited by serious side effects, including analgesic tolerance, constipation, and dependence liabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c412ac66ccb43989202b56cbc27e85
http://hdl.handle.net/11577/3386361
http://hdl.handle.net/11577/3386361