Výsledky vyhledávání - "Karol Nowosad"

Akademický článek

Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints

Autor: Karol Nowosad, Rutger W. W. Brouwer, Adrian Odrzywolski, Anne L. Korporaal, Bartłomiej Gielniewski, Bartosz Wojtaś, Wilfred F. J. van IJcken, Frank Grosveld, Danny Huylebroeck, Przemko Tylzanowski

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract The formation of the synovial joint begins with the visible emergence of a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen called the interzone. Recently the transcriptome of the earl

Externí odkaz: https://doaj.org/article/1d1993d01b414e72859fe01102787e3e

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Chromatin architecture and cis-regulatory landscape of the DACT2-SMOC2 locus in the developing synovial joint

Autor: Karol Nowosad, Ewa Hordyjewska-Kowalczyk, Aneta Malesa, Adrian Odrzywolski, Rutger W. W. Brouwer, Petros Kolovos, Ilias Boltsis, Judith C. Birkhoff, Wilfred F. J. van IJcken, Frank G. Grosveld, Andrea Conidi, Danny Huylebroeck, Przemko Tylzanowski

BackgroundSynovial joints form in several steps, starting with the formation of an interzone, a condensation of mesenchymal cells at the sites of prospective joints. Despite the identification of multiple factors essential for formation of interzone,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc96bf7d963d8b31032359b84e58347d
https://doi.org/10.1101/2022.10.06.511134

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Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome

Autor: Judith C. Birkhoff, Anne L. Korporaal, Rutger W. W. Brouwer, Karol Nowosad, Claudia Milazzo, Lidia Mouratidou, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Danny Huylebroeck, Andrea Conidi

Publikováno v: Genes
Volume 14
Issue 3
Pages: 629

Perturbation and mechanistic studies have shown that the DNA-binding transcription factor Zeb2 controls cell fate decision, differentiation and/or maturation in multiple cell lineages in embryos and after birth. In cultured embryonic stem cells (ESCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c04ed20f884b4e7c40d20607ddae14
https://doi.org/10.3390/genes14030629

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TADeus2: a web server facilitating the clinical diagnosis by pathogenicity assessment of structural variations disarranging 3D chromatin structure

Autor: Barbara Poszewiecka, Victor Murcia Pienkowski, Karol Nowosad, Jérôme D Robin, Krzysztof Gogolewski, Anna Gambin

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (W1), pp.W744-W752. ⟨10.1093/nar/gkac318⟩
Nucleic Acids Research, 50(W1), W744-W752. Oxford University Press

In recent years great progress has been made in identification of structural variants (SV) in the human genome. However, the interpretation of SVs, especially located in non-coding DNA, remains challenging. One of the reasons stems in the lack of too

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e747acf8cfec41a4e4cb38acb2c3287d
https://pubmed.ncbi.nlm.nih.gov/35524567

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Identification of candidate regulatory elements controlling transcriptome during the formation of interphalangeal joints

Autor: Przemko Tylzanowski, Karol Nowosad, Rutger W. W. Brouwer, Adrian Odrzywolski, Anne L. Korporaal, Bartłomiej Gielniewski, Bartosz Wojtaś, Wilfred F. J. van IJcken, Frank Grosveld, Danny Huylebroeck

Formation of the synovial joint starts with the visible emergence of interzone, a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen. Recently the transcriptome of the early synovial joint was re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03faefb4c5140744f42418136e42f443
https://doi.org/10.21203/rs.3.rs-1413327/v1

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Mutations in gene regulatory elements linked to human limb malformations

Autor: Przemko Tylzanowski, Ewa Hordyjewska-Kowalczyk, Karol Nowosad

Publikováno v: Journal of Medical Genetics. 57:361-370

Most of the human genome has a regulatory function in gene expression. The technological progress made in recent years permitted the revision of old and discovery of new mutations outside of the protein-coding regions that do affect human limb morpho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f198fa7cf4c24f6f358c68b771ae024
https://doi.org/10.1136/jmedgenet-2019-106369

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Low Input Targeted Chromatin Capture (Low-T2C)

Autor: Ilias, Boltsis, Karol, Nowosad, Rutger W W, Brouwer, Przemko, Tylzanowski, Wilfred F J, van IJcken, Danny, Huylebroeck, Frank, Grosveld, Petros, Kolovos

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2351

Targeted chromatin capture (T2C) is a 3C-based method and is used to study the 3D chromatin organization, interactomes and structural changes associated with gene regulation, progression through the cell cycle, and cell survival and development. Low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d40cdad2359103c387b30a040aa77640
https://pubmed.ncbi.nlm.nih.gov/34382189

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Low Input Targeted Chromatin Capture (Low-T2C)

Autor: Rutger W W Brouwer, Danny Huylebroeck, Wilfred F. J. van IJcken, Karol Nowosad, Frank Grosveld, Przemko Tylzanowski, Ilias Boltsis, Petros Kolovos

Publikováno v: Methods in Molecular Biology, 165-179
STARTPAGE=165;ENDPAGE=179;TITLE=Methods in Molecular Biology
Methods in Molecular Biology ISBN: 9781071615966

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bc3ea56a9c6c93ec1a36dab7753b14
https://pure.eur.nl/en/publications/8c586abf-930b-4b7c-ad5e-030a19c950e8

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