Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Karol Mizielinski"'
Autor:
Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 657 (2023)
With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA topoisomerases, which are key en
Externí odkaz:
https://doaj.org/article/fd2e9d00fa1443c6b4c2c8d52abb1f5f
Autor:
Kamilla Vandsø Petersen, Asier Selas, Kirstine Mejlstrup Hymøller, Karol Mizielinski, Maria Thorsager, Magnus Stougaard, Concepcion Alonso, Francisco Palacios, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Cinzia Tesauro
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1255 (2021)
Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity may be of interest. All e
Externí odkaz:
https://doaj.org/article/a3e5f7423e284125a5ea60c2ae64f0a2
Autor:
Cinzia Tesauro, Birgitta R. Knudsen, Magnus Stougaard, Kamilla Vandsø Petersen, Karol Mizielinski, Josephine Geertsen Keller
Publikováno v:
Keller, J G, Mizielinski, K, Petersen, K V, Stougaard, M, Knudsen, B R & Tesauro, C 2022, ' Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples ', Journal of visualized experiments : JoVE, vol. 190, e64484 . https://doi.org/10.3791/64484
Isothermal amplification-based techniques such as the rolling circle amplification have been successfully employed for the detection of nucleic acids, protein amounts, or other relevant molecules. These methods have shown to be substantial alternativ
Autor:
Shamith A. Samarajiwa, Ieuan Walker, Zelvera Usheva, Eirini Sidiropoulou, Daniel J. Hodson, Jie Gao, Karol Mizielinski, Joanna Alicja Krupka
Publikováno v:
Blood. 138:959-964
Serum and glucocorticoid-regulated kinase 1 (SGK1) is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL). However, little is known about its function or the consequence of its mutation. The frequent finding of truncatin
Autor:
Magnus Stougaard, Cinzia Tesauro, Rosa M. Reguera, Kamilla Vandsø Petersen, Concepción Alonso, Rafael Balaña-Fouce, Asier Selas, Yolanda Pérez-Pertejo, Kirstine Mejlstrup Hymøller, Karol Mizielinski, Maria Thorsager, Birgitta R. Knudsen, Francisco Palacios
Publikováno v:
Pharmaceutics, Vol 13, Iss 1255, p 1255 (2021)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Petersen, K V, Selas, A, Hymøller, K M, Mizielinski, K, Thorsager, M, Stougaard, M, Alonso, C, Palacios, F, Pérez-Pertejo, Y, Reguera, R M, Balaña-Fouce, R, Knudsen, B R & Tesauro, C 2021, ' Simple and fast DNA based sensor system for screening of small-molecule compounds targeting eukaryotic topoisomerase 1 ', Pharmaceutics, vol. 13, no. 8, 1255 . https://doi.org/10.3390/pharmaceutics13081255
Pharmaceutics
Volume 13
Issue 8
Addi. Archivo Digital para la Docencia y la Investigación
instname
Petersen, K V, Selas, A, Hymøller, K M, Mizielinski, K, Thorsager, M, Stougaard, M, Alonso, C, Palacios, F, Pérez-Pertejo, Y, Reguera, R M, Balaña-Fouce, R, Knudsen, B R & Tesauro, C 2021, ' Simple and fast DNA based sensor system for screening of small-molecule compounds targeting eukaryotic topoisomerase 1 ', Pharmaceutics, vol. 13, no. 8, 1255 . https://doi.org/10.3390/pharmaceutics13081255
Pharmaceutics
Volume 13
Issue 8
Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity may be of interest. All e