Reference intervals for free testosterone in adult men measured using a standardized equilibrium dialysis procedure

Autor: Ravi Jasuja, Karol M. Pencina, Daniel J. Spencer, Liming Peng, Fabiola Privat, Waljit Dhillo, Channa Jayasena, Frances Hayes, Bu B. Yeap, Alvin M. Matsumoto, Shalender Bhasin

Publikováno v: Andrology. 11:125-133

Free testosterone (FT) determination may be helpful in evaluating men suspected of testosterone deficiency especially in conditions with altered binding-protein concentrations. However, methods for measuring FT by equilibrium dialysis and reference i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b11489c0b89bd4d31959f9f6a412dba
https://doi.org/10.1111/andr.13310

MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults

Autor: Karol M Pencina, Siva Lavu, Marcello dos Santos, Yusnie M Beleva, Ming Cheng, David Livingston, Shalender Bhasin

Publikováno v: The Journals of Gerontology: Series A. 78:90-96

Background Nicotinamide adenine dinucleotide (NAD) precursors, nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR) extend healthspan and ameliorate some age-related conditions in model organisms. However, early-phase trials of NAD precur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7312faaac801e347a38946d125d292
https://doi.org/10.1093/gerona/glac049

The Expected 30-Year Benefits of Early Versus Delayed Primary Prevention of Cardiovascular Disease by Lipid Lowering

Autor: Michael J. Pencina, George Thanassoulis, Alberico L. Catapano, Karol M. Pencina, Donald M. Lloyd-Jones, Allan D. Sniderman

Publikováno v: Circulation. 142:827-837

Background: Lipid-lowering recommendations for prevention of atherosclerotic cardiovascular disease rely principally on estimated 10-year risk. We sought to determine the optimal time for initiation of lipid lowering in younger adults as a function o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e510d8a661fb513d8da3dc1a7635de
https://doi.org/10.1161/circulationaha.120.045851

Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium

Autor: Karol M. Pencina, Ralph B. DʼAgostino, Greg Gorsicki, Brian C. Clark, Todd M. Manini, Peggy M. Cawthon, Roger A. Fielding, Jack M. Guralnik, Jane A. Cauley, Jay Magaziner, Jean Woo, Hidenori Arai, Thomas G. Travison, Quian Li Xue, Douglas P. Kiel, Daniel Rooks, Sheena Patel, Rosaly Correa-de-Araujo, Laura A. Schaap, Suzette L. Pereira, Ellen F. Binder, Todd T. Brown, Denise Orwig, Francesco Landi, Cyrus Cooper, Linda J. Woodhouse, Anne B. Newman, Michelle Shardell, Shalender Bhasin

Publikováno v: Bhasin, S, Travison, T G, Manini, T M, Patel, S, Pencina, K M, Fielding, R A, Magaziner, J M, Newman, A B, Kiel, D P, Cooper, C, Guralnik, J M, Cauley, J A, Arai, H, Clark, B C, Landi, F, Schaap, L A, Pereira, S L, Rooks, D, Woo, J, Woodhouse, L J, Binder, E, Brown, T, Shardell, M, Xue, Q L, DʼAgostino, R B, Orwig, D, Gorsicki, G, Correa-De-Araujo, R & Cawthon, P M 2020, ' Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium ', Journal of the American Geriatrics Society, vol. 68, no. 7, pp. 1410-1418 . https://doi.org/10.1111/jgs.16372
Journal of the American Geriatrics Society, 68(7), 1410-1418. Wiley-Blackwell

Objectives To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6907e4818e8f11eba7afe39f79c0a43
https://doi.org/10.1111/jgs.16372

Accurate Measurement and Harmonized Reference Ranges for Total and Free Testosterone Levels

Autor: Ravi Jasuja, Karol M. Pencina, Liming Peng, Shalender Bhasin

Publikováno v: Endocrinology and metabolism clinics of North America. 51(1)

Diagnosing testosterone deficiency requires accurate and precise measurement of total testosterone levels by an accurate method, such as liquid chromatography-tandem mass spectrometry in a laboratory certified by an accuracy-based program (eg, Center

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d71c6183ebf7be6adcd57bc4365ac7
https://pubmed.ncbi.nlm.nih.gov/35216721