Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karol Lacki"'
Publikováno v:
Analytical Chemistry
The traditional approach for analyzing interaction data from biosensors instruments is based on the simplified assumption that also larger biomolecules interactions are homogeneous. It was recently reported that the human receptor angiotensin-convert
The goal of this research is to leverage computational molecular biophysics to guide process development, reduce experimental burden and focus purification activities on feasible targets. Here, we distill a complex separation problem (e.g. chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::395f03e52fca5fb8ad497abdadbe8cfd
https://doi.org/10.22541/au.159050658.84247547
https://doi.org/10.22541/au.159050658.84247547
The number and diversity of antibody like molecules and Fc constructs, such as bispecifics, multispecifics and fusion proteins is increasing. Clinical manufacturing of these molecules is heavily reliant on the protein A, which is firmly established a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70bd9aa6a29d54e5e98bbbfddc352d41
https://doi.org/10.1016/b978-0-08-103019-6.00003-5
https://doi.org/10.1016/b978-0-08-103019-6.00003-5
Autor:
John P. Amara, David M. Bohonak, Benjamin Cacace, Mike Collins, Brandon Coyle, Paul W. Genest, Mirna González-González, Elizabeth M. Goodrich, Elina Gousseinov, Akshat Gupta, Sophia Hober, Sara Kanje, Aydin Kavara, Kelley Kearns, John F. Kelly, Warren Kett, Karol Lacki, Yifeng Li, Allan Matte, Karla Mayolo-Deloisa, Anup Mohanty, Johan Nilvebrant, Emily Peterson, Marco Rito-Palomares, Anna C. Robotham, Thomas Scanlon, Julia Scheffel, Mark Schofield, Peter (Keqiang) Shen, David Sokolowski, Ying Wang, Weichang Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1694da13bee88b696de9bdc1e5133d40
https://doi.org/10.1016/b978-0-08-103019-6.01002-x
https://doi.org/10.1016/b978-0-08-103019-6.01002-x
Autor:
Heera Khan, Linda Mathiasson, Collette M. Cutler, Hong Li, David J. Roush, Karol Lacki, Hanno Ehring, Hans Blom, Nihal Tugcu, Daniel Go, Rebecca A. Chmielowski
Publikováno v:
Journal of Chromatography A. 1526:58-69
Advances in cell culture technology have enabled the production of antibody titers upwards of 30g/L. These highly productive cell culture systems can potentially lead to productivity bottlenecks in downstream purification due to lower column loadings
Autor:
Karol Lacki, Tryggve Bergander
Publikováno v:
Engineering in Life Sciences. 16:185-189
Prediction of chromatographic separations in liter scale with the help of data gathered using a microliter format is challenging, as both scale effects and differences in the formats used (plates vs. packed minicolumns) need to be addressed. The use
Autor:
Eggert Brekkan, David J. Roush, Karol Lacki, Jennifer M. Pollard, Haiying Bao, Thomas O. Linden, Kenneth Barlow, John P. Welsh
Publikováno v:
Engineering in Life Sciences. 16:160-168
Scale-down, high-throughput screening techniques are well on their way to becoming a commodity in downstream bioprocess development, especially for the rapid development of chromatography process steps. This work used both resin slurry plate and mini
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist,
Publikováno v:
Journal of Chemical Technology & Biotechnology. 89:1534-1544
BACKGROUND This study ascertains the degree to which bioseparation techniques, considered as alternatives to packed bed chromatography, have been adopted for large-scale biomanufacturing. Such information will be useful to process engineers intereste
Publikováno v:
Biotechnology Progress. 24:1007-1025
Advances in upstream technologies and growing commercial demand have led to cell culture processes of ever larger volumes and expressing at higher product titers. This has increased the burden on downstream processing. Concerns regarding the capacity