Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Karol L. Thompson"'
Autor:
P. Scott Pine, Steven P. Lund, Jerod R. Parsons, Lindsay K. Vang, Ashish A. Mahabal, Luca Cinquini, Sean C. Kelly, Heather Kincaid, Daniel J. Crichton, Avrum Spira, Gang Liu, Adam C. Gower, Harvey I. Pass, Chandra Goparaju, Steven M. Dubinett, Kostyantyn Krysan, Sanford A. Stass, Debra Kukuruga, Kendall Van Keuren-Jensen, Amanda Courtright-Lim, Karol L. Thompson, Barry A. Rosenzweig, Lynn Sorbara, Sudhir Srivastava, Marc L. Salit
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background The potential utility of microRNA as biomarkers for early detection of cancer and other diseases is being investigated with genome-scale profiling of differentially expressed microRNA. Processes for measurement assurance are criti
Externí odkaz:
https://doaj.org/article/3dc1b4d4cf0f47c2b8b7f1d1e6ce5522
Autor:
Russell D. Wolfinger, Sudheer Beedanagari, Eric Boitier, Tao Chen, Philippe Couttet, Heidrun Ellinger-Ziegelbauer, Gregory Guillemain, Claire Mariet, Peter Mouritzen, Raegan O’Lone, P. Scott Pine, Tatiana Sharapova, Jian Yan, Peter S. Yuen, Karol L. Thompson
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Circulating microRNAs are undergoing exploratory use as safety biomarkers in drug development. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is one common approach used to quantitate levels of microRNAs in
Externí odkaz:
https://doaj.org/article/c2c793e7d8a5491ead046c944c014fad
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 160:238-243
Protamine sulfate (PS) is an FDA approved drug used to reverse heparin-induced anticoagulation in patients. Protamine sulfate is a mixture of primarily four ∼4 kDa arginine-rich cationic polypeptide chains derived from chum (Oncorhynchus keta) salm
Autor:
Sharron Stewart, Lin Xu, Katie Shea, Rodney Rouse, Leah M Zadrozny, Alan Knapton, Karol L. Thompson, Ashok Chockalingam, Barry A. Rosenzweig
Publikováno v:
Experimental and Toxicologic Pathology. 69:33-43
Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine
Publikováno v:
Data in Brief, Vol 21, Iss, Pp 644-652 (2018)
Data in Brief
Data in Brief
Protamine sulfate (PS) is an approximately 4 kDa cationic polypeptide derived from chum salmon used to reverse heparin-induced anticoagulation in patients. Because the presence of residual host cell salmon DNA (resDNA) in PS drug product can pose saf
Autor:
Chandra Goparaju, Gang Liu, Amanda Courtright-Lim, Luca Cinquini, Debra Kukuruga, Heather Kincaid, Ashish Mahabal, Steven M. Dubinett, Harvey I. Pass, P. Scott Pine, Lynn Sorbara, Avrum Spira, Jerod Parsons, Steven P. Lund, Karol L. Thompson, Adam C. Gower, Kendall Van Keuren-Jensen, Marc L. Salit, Sanford A. Stass, Sean Kelly, Lindsay K. Vang, Daniel J. Crichton, Kostyantyn Krysan, Barry A. Rosenzweig, Sudhir Srivastava
Publikováno v:
BMC genomics, vol 19, iss 1
BMC Genomics
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
BMC Genomics
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
BackgroundThe potential utility of microRNA as biomarkers for early detection of cancer and other diseases is being investigated with genome-scale profiling of differentially expressed microRNA. Processes for measurement assurance are critical compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2796e04f2b465eb6d0eb1b995d0a0b20
https://escholarship.org/uc/item/2w09g0d8
https://escholarship.org/uc/item/2w09g0d8
Autor:
Peter Mouritzen, Tatiana Sharapova, Gregory Guillemain, Heidrun Ellinger-Ziegelbauer, Karol L. Thompson, Sudheer Beedanagari, Russell D. Wolfinger, Eric Boitier, Tao Chen, Raegan O’Lone, Philippe Couttet, Claire Mariet, Peter S.T. Yuen, P. Scott Pine, Jian Yan
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 18, Iss 1, Pp 1-9 (2018)
BMC Biotechnology, Vol 18, Iss 1, Pp 1-9 (2018)
Background Circulating microRNAs are undergoing exploratory use as safety biomarkers in drug development. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is one common approach used to quantitate levels of microRNAs in samples
Autor:
John P. Nolan, Jennifer B. Pierson, Marjory B. Brooks, James R. Turk, Cindy E. Fishman, Dennis W Wilson, Heidrun Ellinger-Ziegelbauer, Albert E. Schultze, April Paulman, Karol L. Thompson, Padma K. Narayanan, Abraham Guerrero, Elizabeth G. Besteman, Roberta A. Thomas, Alan Y. Chiang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
PLoS ONE
PLoS ONE
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Autor:
John Todd, Quynh Anh Lu, Joel Estis, Brian B. Hasinoff, Steven E. Lipshultz, Jun Zhang, Barry A. Rosenzweig, Sara J. Agee, Elliot T. Rosen, Karol L. Thompson, Alan Knapton, Eugene H. Herman
Publikováno v:
Toxicologic Pathology. 39:1091-1106
Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify import
Autor:
Laura Suter, Aliza Thompson, Ernie Harpur, Gerard Maurer, Bruno Flamion, Douglas C. Throckmorton, Phil Rossi, Jackie Akunda, Nancy Xu, Stefan Sultana, Federico Goodsaid, Jonathan A. Phillips, Sven A. Beushausen, Valérie G. Barlow, Denise Bounous, Jacky Vonderscher, David Gerhold, Sean P. Troth, Elizabeth Hausner, Karol L. Thompson, Matthew J. Schipper, Spiros Vamvakas, David Jacobson-Kram, William Taylor, Jean Marc Vidal, Beatriz Silva Lima, Albert F. Defelice, Supriya Jayadev, Magalie Guffroy, Yi Zhong Gu, James Eric McDuffie, Daniela Ennulat, Jeff Waring, Patricia Harlow, Leslie A. Obert, Sandra Snook, Frank D. Sistare, Eric A.G. Blomme, William B. Mattes, Craig P. Webb, Mark Pinches, David Honor, Romaldas Mačiulaitis, Myrtle Davis, Jinhe Lee, Frank Dieterle, Marisa Papaluca, Melanie Blank, Nathaniel Collins, William Baer, Peter L. Goering, Shen Xiao, Anthony J. Senagore, Krishna Prasad, Denise Robinson-Gravatt, Josef S Ozer, Eric Abadie, Graham Betton, Kevin Carl, Peter Kasper, David Laurie, Manisha Sonee, Dina Andrews-Cleavenger, Elizabeth G. Walker, Dan Holder, Markku Pasanen
Publikováno v:
Nature Biotechnology. 28:455-462
The first formal qualification of safety biomarkers for regulatory decision making marks a milestone in the application of biomarkers to drug development. Following submission of drug toxicity studies and analyses of biomarker performance to the Food