Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karol D. McNeill"'
Autor:
Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayko
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16523 (2011)
Statins inhibit the proximal steps of cholesterol biosynthesis, and are linked to health benefits in various conditions, including cancer and lung disease. We have previously investigated apoptotic pathways triggered by statins in airway mesenchymal
Externí odkaz:
https://doaj.org/article/355b8c38925742648fe47238996f5963
Autor:
Gordon Dueck, Helmut Unruh, Saeid Ghavami, Grant M. Hatch, Andrew J. Halayko, Andrea Kroeker, Dedmer Schaafsma, Karol D. McNeill, Mark M. Mutawe, Kristin Hauff, Fred Y. Xu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:394-403
Smooth muscle cells promote fibroproliferative airway remodeling in asthma, and transforming growth factor β1 (TGFβ1) is a key inductive signal. Statins are widely used to treat hyperlipidemia. Growing evidence indicates they also exert a positive
Autor:
Andrew J. Halayko, Mark M. Mutawe, Gerald L. Stelmack, Karol D. McNeill, Reinoud Gosens, William T. Gerthoffer, Pawan K. Sharma, Thai Tran, Helmut Unruh
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 294(1), L57-L68. AMER PHYSIOLOGICAL SOC
Airway smooth muscle (ASM) cells may contribute to asthma pathogenesis through their capacity to switch between a synthetic/proliferative and a contractile phenotype. The multimeric dystrophin-glycoprotein complex (DGC) spans the sarcolemma, linking
Autor:
Helmut Unruh, Karol D. McNeill, Andrew J. Halayko, Karen Ens-Blackie, Edward S. Rector, Gerald L. Stelmack, William T. Gerthoffer, Guido Tarone, Thai Tran
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 37:668-680
Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma. We h
Autor:
Reinoud Gosens, Karol D. McNeill, Johan Zaagsma, Angela Paulson, Helmut Unruh, Gerald L. Stelmack, Mark M. Mutawe, Andrew J. Halayko, James A. Thliveris, Shyamala Dakshinamurti, William T. Gerthoffer, Martha Hinton, Gordon Dueck
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 293(6), L1406-L1418. AMER PHYSIOLOGICAL SOC
Contractile responses of airway smooth muscle (ASM) determine airway resistance in health and disease. Caveolae microdomains in the plasma membrane are marked by caveolin proteins and are abundant in contractile smooth muscle in association with nano
Autor:
Karen M. Ens, Jelte-Maarten Penninks, Hoeke A. Baarsma, S. Adriaan Nelemans, Dedmer Schaafsma, Reinoud Gosens, Gerald L. Stelmack, Bart G. J. Dekkers, Johan Zaagsma, Erin Frohwerk, Karol D. McNeill, Herman Meurs, Andrew J. Halayko, Pawan K. Sharma
Publikováno v:
American journal of physiology-Cell physiology, 293(1), C429-C439. AMER PHYSIOLOGICAL SOC
We have previously demonstrated that long-term exposure of bovine tracheal smooth muscle (BTSM) strips to insulin induces a functional hypercontractile phenotype. To elucidate molecular mechanisms by which insulin might induce maturation of contracti
Autor:
Reinoud Gosens, Andrew J. Halayko, Abdelilah S. Gounni, Gerald L. Stelmack, Akira Yamasaki, William T. Gerthoffer, Karol D. McNeill, Helmut Unruh, Johan Zaagsma, Gordon Dueck
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 291(3), L523-L534. AMER PHYSIOLOGICAL SOC
Chronic airways diseases, including asthma, are associated with an increased airway smooth muscle (ASM) mass, which may contribute to chronic airway hyperresponsiveness. Increased muscle mass is due, in part, to increased ASM proliferation, although
Autor:
J. Elliot Scott, Hong Wei Liu, Andrew J. Halayko, Gerald L. Stelmack, Lu Wang, Karol D. McNeill
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 31:54-61
Mechanical strain affects airway myocyte phenotype, cytoskeletal architecture, proliferation, and contractile function. We hypothesized that (i) short-term mechanical strain modulates transcription of smooth muscle-specific gene promoters for SM22 an
Autor:
Karol D. McNeill, I. R. Hamilton
Publikováno v:
Microbiology. 150:735-742
Streptococcus mutans is a component of the dental plaque biofilm and an important aetiological agent in dental caries. Although this organism growing in the suspended (planktonic) state has been well characterized, relatively little is known about it
Autor:
I. R. Hamilton, Karol D. McNeill
Publikováno v:
FEMS Microbiology Letters. 221:25-30
Streptococcus mutans, a major etiological agent of dental caries, is a component of the dental plaque biofilm and functions during caries progression in acidic lesions that may be at or below pH 4. In this study, we were interested in determining the