Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Karol Bialkowski"'
Autor:
Marek Foksinski, Ewelina Zarakowska, Daniel Gackowski, Magdalena Skonieczna, Karolina Gajda, Dorota Hudy, Anna Szpila, Karol Bialkowski, Marta Starczak, Anna Labejszo, Jaroslaw Czyz, Joanna Rzeszowska-Wolny, Ryszard Olinski
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195819 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0188856.].
Externí odkaz:
https://doaj.org/article/bfe567fd5ad9449ea91d337a4387b652
Autor:
Marek Foksinski, Ewelina Zarakowska, Daniel Gackowski, Magdalena Skonieczna, Karolina Gajda, Dorota Hudy, Anna Szpila, Karol Bialkowski, Marta Starczak, Anna Labejszo, Jaroslaw Czyz, Joanna Rzeszowska-Wolny, Ryszard Olinski
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188856 (2017)
Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed by enzymes of the Ten-Eleven Translocation family proteins (TETs 1, 2 and 3). Here
Externí odkaz:
https://doaj.org/article/a7f2ed3061a14863b91a8d82c49db149
Autor:
Karol Bialkowski, Anna Szpila
Publikováno v:
Free Radical Biology and Medicine. 176:257-264
The MTH1 (NUDT1) gene, because it is frequently upregulated in many types of human cancers, has been considered a general marker of carcinogenesis for over two decades. The MTH1 protein hydrolyzes the oxidized mutagenic DNA precursor, 8-oxo-7,8-dihyd
Autor:
Karol Bialkowski
Publikováno v:
Acta Biochimica Polonica.
Our goal was to verify the proteolytic mode of action and activity levels among several commercial cosmetic facial peels advertised by manufacturers as “enzymatic”. Eleven enzyme peels were analyzed for their proteolytic activity against casein a
Publikováno v:
Free Radical Biology and Medicine. 148:1-21
We measured the specific 8-oxo-dGTPase activity profile of the NCI-60 panel of malignant cell lines, and MTH1 protein levels in a subset of 16 lines. Their 8-oxo-dGTPase activity was compared to twelve publicly accessible MTH1 mRNA expression data ba
Autor:
Ryszard Olinski, Magdalena Skonieczna, Karol Bialkowski, Dorota Hudy, Marek Foksinski, Anna Labejszo, Karolina Gajda, Marta Starczak, Ewelina Zarakowska, Daniel Gackowski, Joanna Rzeszowska-Wolny, Anna Szpila, Jarosław Czyż
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195819 (2018)
PLoS ONE
PLoS ONE
Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed by enzymes of the Ten-Eleven Translocation family proteins (TETs 1, 2 and 3). Here
Publikováno v:
Radiation Research. 172:187-197
Mammalian MTH1 protein is an antimutagenic (2'-deoxy)ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of
Publikováno v:
Free Radical Biology and Medicine. 37:1534-1541
Mammalian MTH1 proteins, homologs of Escherichia coli MutT, are enzymes decomposing 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) to 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-monophosphate and inorganic pyrophosphate. They play an ant
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 678:77-81
Stabilities of N-glycosidic bond of N9-methoxymethyl guanosine, 8-oxo-guanosine, xanthine and fapy-guanosine in its most abundant tautomeric forms were studied by means of ab inito quantum chemistry methods. Gibbs free energies were estimated for all
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 531:177-190
A wide variety of oxidative DNA lesions are present in living cells. One of the best known lesions of this type is 8-oxoguanine (8-oxoGua) which has been shown to have mutagenic properties. An influence of antioxidative vitamins and labile iron pool