Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karol Al Ayed"'
Autor:
Karol Al Ayed, Denise Zamarbide Losada, Nataliia V. Machushynets, Barbara Terlouw, Somayah S. Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Marnix H. Medema, Gilles P. van Wezel, Nathaniel I. Martin
Publikováno v:
ACS Infectious Diseases 9 (2023) 4
ACS Infectious Diseases, 9(4), 739-748
ACS Infectious Diseases, 9(4), 739-748
The unabated rise of antibiotic resistance has raised the specter of a post-antibiotic era and underscored the importance of developing new classes of antibiotics. The relacidines are a recently discovered group of nonribosomal lipopeptide antibiotic
Autor:
Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin, Stephen A. Cochrane
Publikováno v:
Ballantine, R D, Al Ayed, K, Bann, S J, Hoekstra, M, Martin, N I & Cochrane, S A 2023, ' Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity ', Journal of Medicinal Chemistry, vol. 66, no. 8, pp. 6002–6009 . https://doi.org/10.1021/acs.jmedchem.3c00308
Brevicidine and laterocidine are macrocyclic lipodepsipeptides with selective activity against Gram-negative bacteria, including colistin-resistant strains. Previously, the macrocyclic core of these peptides was thought essential for antibacterial ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09c03c0cc76ae7e5befbc94a8558900
https://pure.qub.ac.uk/en/publications/b4f5f24c-7d26-4f15-abf5-6953f2f2c8b3
https://pure.qub.ac.uk/en/publications/b4f5f24c-7d26-4f15-abf5-6953f2f2c8b3
Autor:
Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin, Stephen A. Cochrane
Publikováno v:
Ballantine, R D, Al Ayed, K, Bann, S J, Hoekstra, M, Martin, N I & Cochrane, S A 2022, ' Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine ', RSC Medicinal Chemistry, vol. 13, no. 12, pp. 1640-1643 . https://doi.org/10.1039/D2MD00281G
RSC Medicinal Chemistry, 13, 1640-1643. Royal Society of Chemistry (RSC)
RSC Medicinal Chemistry, 13, 1640-1643. Royal Society of Chemistry (RSC)
The brevicidine and laterocidine family of lipopeptide antibiotics exhibit strong activity against multidrug-resistant Gram-negative bacteria, while showing low propensity to induce resistance. Both peptides feature a branched lipid tail on the N-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121dece8cf31225048d484c4d78ce224
https://pure.qub.ac.uk/en/publications/64b92b45-9d67-43eb-a9f8-6feea03fd68f
https://pure.qub.ac.uk/en/publications/64b92b45-9d67-43eb-a9f8-6feea03fd68f
Autor:
Karol Al Ayed, Ross D. Ballantine, Michael Hoekstra, Samantha J. Bann, Charlotte M. J. Wesseling, Alexander T. Bakker, Zheng Zhong, Yong-Xin Li, Nora C. Brüchle, Mario van der Stelt, Stephen A. Cochrane, Nathaniel I. Martin
Publikováno v:
Chemical Science, 13(12), 3563-3570. Royal Society of Chemistry (RSC)
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d745f9e19bc1cc2b080c620d433bcaa3
http://hdl.handle.net/1887/3304472
http://hdl.handle.net/1887/3304472
Autor:
Karol Al-Ayed, Ross D. Ballantine, Michael Hoekstra, Samantha Bann, Charlotte Wesseling, Alexander Bakker, Zheng Zhong, Yongxin Li, Mario van der Stelt, Stephen Cochrane, Nathaniel Martin
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecff4d5277c1bd5df6798e9bad946499
https://doi.org/10.26434/chemrxiv-2022-15r0h-v2
https://doi.org/10.26434/chemrxiv-2022-15r0h-v2
Autor:
Karol, Al Ayed, Ross D, Ballantine, Michael, Hoekstra, Samantha J, Bann, Charlotte M J, Wesseling, Alexander T, Bakker, Zheng, Zhong, Yong-Xin, Li, Nora C, Brüchle, Mario, van der Stelt, Stephen A, Cochrane, Nathaniel I, Martin
Publikováno v:
Chemical science. 13(12)
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Autor:
Nathaniel Martin, Stephen Cochrane, Yongxin Li, Zheng Zhong, Ross D. Ballantine, Karol Al-Ayed
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e296f257996668cf1b0c9773ef25e3
https://doi.org/10.26434/chemrxiv.13660949
https://doi.org/10.26434/chemrxiv.13660949
Autor:
Tom van der Wel, Tiemen J Wendel, Gerard J. P. van Westen, Yvonne Tran, Ming Jiang, Florian Mohr, Karol Al Ayed, Anna F. Stevens, Andrea Martella, Vasudev Kantae, Mario van der Stelt, Tim P Ofman, Lindsey Burggraaff, Juan Zhou, Thomas Hankemeier, Elliot D. Mock, Xinyu Di, Nicky de Koster
Publikováno v:
Journal of Medicinal Chemistry, 63(17), 9340-9359
International Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
International Journal of Medicinal Chemistry, 63(17), 9340-9359. AMER CHEMICAL SOC
International Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
International Journal of Medicinal Chemistry, 63(17), 9340-9359. AMER CHEMICAL SOC
The phospholipase A and acyltransferase (PLAAT) family of cysteine hydrolases consists of five members, which are involved in the Ca2+-independent production of N-acylphosphatidylethanolamines (NAPEs). NAPEs are lipid precursors for bioactive N-acyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73a1e6d854047c76c9a7a9b70d7c836
https://hdl.handle.net/1887/138231
https://hdl.handle.net/1887/138231
Autor:
Hans den Dulk, Laura Mulder, Lindsey Burggraaff, Thomas Hankemeier, Juan Zhou, Marc P. Baggelaar, Andrea Martella, Bogdan I. Florea, Alexander T Bakker, Mario van der Stelt, Karol Al-Ayed, Chun T. Li, Gerard J. P. van Westen, Herman S. Overkleeft, Vasudev Kantae, Elliot D. Mock, Xinyu Di, Sebastian H. Grimm
Publikováno v:
ACS Chemical Biology, 14(2), 164-169
ACS Chemical Biology
ACS Chemical Biology
Phospholipase A2, group XVI (PLA2G16) is a thiol hydrolase from the HRASLS family that regulates lipolysis in adipose tissue and has been identified as a host factor enabling the cellular entry of picornaviruses. Chemical tools are essential to visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca19c73d265df10e65e3bb195c5746cb
http://hdl.handle.net/1887/69904
http://hdl.handle.net/1887/69904
Autor:
Karol Al-Ayed, Kyung Bo Kim, Eva M. Huber, Gijsbert A. van der Marel, Alexei F. Kisselev, Christoph Driessen, Herman S. Overkleeft, Gerjan de Bruin, Eva J. van Rooden, Bo-Tao Xin, Mario van der Stelt, Michael Groll
Publikováno v:
Journal of medicinal chemistry
Mammalian genomes encode seven catalytic proteasome subunits, namely, β1c, β2c, β5c (assembled into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into immunoproteasomes), and the thymoproteasome-specific subunit β5t.