Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens

Autor: Dominik Arbon, Kateřina Ženíšková, Karolína Šubrtová, Jan Mach, Jan Štursa, Marta Machado, Farnaz Zahedifard, Tereza Leštinová, Carolina Hierro-Yap, Jiri Neuzil, Petr Volf, Markus Ganter, Martin Zoltner, Alena Zíková, Lukáš Werner, Robert Sutak

Many of the currently available anti-parasitic and anti-fungal frontline drugs have severe limitations, including adverse side effects, complex administration, and increasing occurrence of resistance. The discovery and development of new therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cc41a7b6d33d13bb16d6019b139482a
https://doi.org/10.1101/2022.03.24.485593

Bioenergetic consequences of F

Autor: Carolina, Hierro-Yap, Karolína, Šubrtová, Ondřej, Gahura, Brian, Panicucci, Caroline, Dewar, Christos, Chinopoulos, Achim, Schnaufer, Alena, Zíková

Publikováno v: The Journal of Biological Chemistry

Mitochondrial ATP synthase is a reversible nanomotor synthesizing or hydrolyzing ATP depending on the potential across the membrane in which it is embedded. In the unicellular parasite Trypanosoma brucei, the direction of the complex depends on the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b653e3473a6044b059498967bf6b511
https://pubmed.ncbi.nlm.nih.gov/33539923

Bioenergetic consequences of FoF1–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei

Autor: Alena Zíková, Carolina Hierro-Yap, Christos Chinopoulos, Ondřej Gahura, Caroline E. Dewar, Brian Panicucci, Karolína Šubrtová, Achim Schnaufer

Publikováno v: Hierro Yap, C, Subrtova, K, Gahura, O, Panicucci, B, Dewar, C, Chinopoulos, C, Schnaufer, A & Zíková, A 2021, ' Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei ', Journal of Biological Chemistry, vol. 296, 100357 . https://doi.org/10.1016/j.jbc.2021.100357

Mitochondrial ATP synthase is a reversible nanomotor synthesizing or hydrolyzing ATP depending on the potential across the membrane in which it is embedded. In the unicellular parasite Trypanosoma brucei, the direction of the complex depends on the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245e026e9d5344a50b6f797f23970d9e
https://doi.org/10.1016/j.jbc.2021.100357

ADP/ Mg2+ inhibition of F1 ATPases is tuned using Mg2+ affinity governed by species-specific γ subunit contacts to α and β subunits

Autor: Peter-Leon Hagedoorn, Stefan R. Marsden, Kirsten C.C. Knobel, Karolína Šubrtová, Gregory M. Cook, Hiroyuki Noji, Achim Schnaufer, Duncan G. G. McMillan

Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e80-e81

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6880f4067d1d6d0feefe74d64fc9cfcb
https://doi.org/10.1016/j.bbabio.2018.09.241

ATPaseTb2, a unique membrane-bound FoF1-ATPase component, is essential in bloodstream and dyskinetoplastic trypanosomes

Autor: Karolína Šubrtová, Alena Zíková, Brian Panicucci

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 2, p e1004660 (2015)

In the infectious stage of Trypanosoma brucei, an important parasite of humans and livestock, the mitochondrial (mt) membrane potential (Δψm) is uniquely maintained by the ATP hydrolytic activity and subsequent proton pumping of the essential FoF1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093fcef7b4a80c3b163cc5fc096601d2
https://pubmed.ncbi.nlm.nih.gov/25714685