Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karol, Palasiewicz"'
Autor:
Lijian Shao, Kilian Sottoriva, Karol Palasiewicz, Jizhou Zhang, James Hyun, Sweta S. Soni, Na Yoon Paik, Xiaopei Gao, Henar Cuervo, Asrar B. Malik, Jalees Rehman, Daniel Lucas, Kostandin V. Pajcini
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypo
Externí odkaz:
https://doaj.org/article/c7d358a8235d4d9c9812091cb315a357
Autor:
Anja Meyer, Ryan Sienes, Brian Zanotti, Katrien van Raemdonck, Karol Palasiewicz, Daniel P. Mass, Michael V. Volin, Shiva Shahrara
Publikováno v:
Cellular & Molecular Immunology. 19:1070-1072
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39963d3fcde68d26d0be9e506c532e80
https://doi.org/10.1038/s41423-022-00886-x
https://doi.org/10.1038/s41423-022-00886-x
Autor:
Shiva Arami, Nadera J. Sweiss, Rani Rahat, Christian Ascoli, Bianca Romay, Karol Palasiewicz, Shiva Shahrara, Ryan K Zomorrodi, Chandana Tetali, Michael V. Volin, Monica Guma, Luke A. J. O'Neill, Sadiq Umar
Publikováno v:
Cellular and Molecular Life Sciences. 78:7693-7707
Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function. Yet, the metabolic reconfiguration of RA macrophages (MΦs) is incompletely understood during active disease and in crosstalk with other cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f3eb915b19fcdb0c4664573675f3866
https://doi.org/10.1007/s00018-021-03978-5
https://doi.org/10.1007/s00018-021-03978-5
Autor:
Azam Ahmed, Michael V. Volin, M. Asif Amin, Karol Palasiewicz, Chandana Tetali, Ryan K Zomorrodi, Hatem A Elshabrawy, Nadera J. Sweiss, Katrien Van Raemdonck, Sadiq Umar, Bianca Romay, Shiva Shahrara
Publikováno v:
Arthritis & Rheumatology. 73:2003-2014
OBJECTIVE In rheumatoid arthritis (RA), elevated serum interleukin-34 (IL-34) levels are linked with increased disease severity. IL-34 binds to 2 receptors, macrophage colony-stimulating factor receptor (M-CSFR) and syndecan 1, which are coexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354151b18a6281d729c872bcb2b2fbcb
https://doi.org/10.1002/art.41792
https://doi.org/10.1002/art.41792
Publikováno v:
European Journal of Immunology
The molecular mechanism of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spike protein was characterized to identify novel therapies. The impact of tofacitinib, IL‐6R Ab, or TNFi therapy was determined on Spike protein or LPS/IFN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2640ef85edc5680f70fdd961c519e9a8
https://doi.org/10.1002/eji.202049159
https://doi.org/10.1002/eji.202049159
Autor:
Karol Palasiewicz, Imran Ahmad, Nadera J. Sweiss, Chandana Tetali, Michael V. Volin, Katrien Van Raemdonck, M. Asif Amin, Bianca Romay, Shiva Shahrara, Ryan K Zomorrodi, Sadiq Umar
Publikováno v:
Eur J Immunol
This study elucidates the mechanism of CCL25 and CCR9 in rheumatoid arthritis (RA). RA synovial fluid (SF) expresses elevated levels of CCL25 compared to OA SF and plasma from RA and normal. CCL25 was released into RA SF by fibroblasts (FLS) and macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5f8828c5c058f79a4a109195522ffd
https://doi.org/10.1002/eji.202048681
https://doi.org/10.1002/eji.202048681
Autor:
Sadiq Umar, Karol Palasiewicz, Anja Meyer, Prabhakaran Kumar, Bellur S. Prabhakar, Michael V. Volin, Rani Rahat, Mina Al-Awqati, Huan J. Chang, Ryan K. Zomorrodi, Jalees Rehman, Shiva Shahrara
Publikováno v:
Cellular and Molecular Life Sciences. 79
Escalated innate immunity plays a critical role in SARS-CoV-2 pathology; however, the molecular mechanism is incompletely understood. Thus, we aim to characterize the molecular mechanism by which SARS-CoV-2 Spike protein advances human macrophage (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f16f6e7ed6135a0ca7a8072eebd80
https://doi.org/10.1007/s00018-022-04329-8
https://doi.org/10.1007/s00018-022-04329-8
Autor:
Katrien Van Raemdonck, Shiva Shahrara, Huan J Chang, Sadiq Umar, Anja Meyer, Ryan K Zomorrodi, Mina Al-Awqati, Michael V. Volin, Karol Palasiewicz
Publikováno v:
Immunol Cell Biol
The current study was designed to delineate the functional significance of CCL21 on metabolic reprogramming in experimental arthritis and rheumatoid arthritis (RA) differentiated macrophages (MΦs). To characterize the influence of CCL21 on immunomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63352b76a359e56c6ab08fb46456914
https://europepmc.org/articles/PMC8810694/
https://europepmc.org/articles/PMC8810694/
Autor:
Shiva Shahrara, Michael V. Volin, Sadiq Umar, Nadera J. Sweiss, Karol Palasiewicz, Mina Al-Awqati, Brian Zanotti
Publikováno v:
Life Sci
Recent studies show a connection between glycolysis and inflammatory response in rheumatoid arthritis (RA) macrophages (MΦs) and fibroblasts (FLS). Yet, it is unclear which pathways could be targeted to rebalance RA MΦs and FLS metabolic reprogramm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2a0ff0ca0f980fb5d2f8f0e6242d68
https://europepmc.org/articles/PMC10020992/
https://europepmc.org/articles/PMC10020992/
Autor:
Kilian Sottoriva, Karol Palasiewicz, James Hyun, Xiaopei Gao, Henar Cuervo, Sweta S. Soni, Na Yoon Paik, Asrar B. Malik, Kostandin V. Pajcini, Lijian Shao, Jalees Rehman, Jizhou Zhang, Daniel Lucas
Publikováno v:
Haematologica. 104:2164-2177
Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b50bf51accaad0de8bd8ae559dbba2e
https://doi.org/10.3324/haematol.2018.208660
https://doi.org/10.3324/haematol.2018.208660