Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Karol, Michalak"'
Publikováno v:
Advanced Synthesis & Catalysis. 363:1317-1321
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c245ce5c0cf79c9ed085ecb89fd7b50
https://doi.org/10.1002/adsc.202001043
https://doi.org/10.1002/adsc.202001043
Publikováno v:
European Journal of Medicinal Chemistry. 180:417-429
Oleandrin, the major biologically active constituent of shrub Nerium oleander preparations of which have been used in traditional Mediterranean and Asian medicine, attracts a great deal of attention due to its pronounced anticancer activity. The synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f16980bb85695a0c100144df9a3c3e16
https://doi.org/10.1016/j.ejmech.2019.07.028
https://doi.org/10.1016/j.ejmech.2019.07.028
Autor:
Karol, Michalak, Lucie, Rárová, Martin, Kubala, Petra, Čechová, Miroslav, Strnad, Jerzy, Wicha
Publikováno v:
European journal of medicinal chemistry. 180
Oleandrin, the major biologically active constituent of shrub Nerium oleander preparations of which have been used in traditional Mediterranean and Asian medicine, attracts a great deal of attention due to its pronounced anticancer activity. The synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97f4714cac08fad6bcb936ebf2cccb22
https://pubmed.ncbi.nlm.nih.gov/31325787
https://pubmed.ncbi.nlm.nih.gov/31325787
Publikováno v:
Advanced Synthesis & Catalysis. 363:1159-1159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91fe96df3023936eead67c8d6b5bc8a
https://doi.org/10.1002/adsc.202100049
https://doi.org/10.1002/adsc.202100049
Publikováno v:
Organic Letters. 18:6148-6151
The first synthetic approach to the core structure of cardiac glycoside oleandrin exhibiting a potent cytotoxic activity, starting from a common androstane derivative, has been accomplished. The synthesis is focused on stereoselective transformations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83bd02744cea49937eefb98b1b46756
https://doi.org/10.1021/acs.orglett.6b03157
https://doi.org/10.1021/acs.orglett.6b03157
Publikováno v:
Tetrahedron. 72:4813-4820
Dynamic kinetic resolution through metal complex induced racemization and Candida antarctica lipase mediated enantioselective acetylation of a model hydroxy-ketone: 4-hydroxy-2-methylcyclopent-2-en-1-one and its selected derivatives, has been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::275e2291f6a91004f0d37220240acfe4
https://doi.org/10.1016/j.tet.2016.06.047
https://doi.org/10.1016/j.tet.2016.06.047
Publikováno v:
European Journal of Medicinal Chemistry. 202:112520
Natural cardiac-active principles built upon the 14,16β-dihydroxy-5β,14β-androstane core and bearing a heterocyclic substituent at 17β, in particular, a cardenolide - oleandrin and a bufadienolide - bufotalin, are receiving a great deal of attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c22fa1d004294ff1046c54c7c95e8cbd
https://doi.org/10.1016/j.ejmech.2020.112520
https://doi.org/10.1016/j.ejmech.2020.112520
Publikováno v:
Natural product reports. 34(4)
Covering: early studies through to March 2016 Cardenolides and bufadienolides constitute an attractive class of biologically active steroid derivatives which have been used for the treatment of heart disease in traditional remedies as well as in mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1517982e4f2fa051a4992d2d75c2e7e
https://pubmed.ncbi.nlm.nih.gov/28378871
https://pubmed.ncbi.nlm.nih.gov/28378871
Autor:
Jerzy Wicha, Karol Michalak
Publikováno v:
Tetrahedron. 70:5073-5081
A method for the preparation of (S)-4-hydroxy-2-methylcyclopent-2-en-1-one from 1-(2-furyl)ethanol using modified Piancatelli rearrangement and enzymatic kinetic resolution of the racemate was developed. An application of O-protected derivatives of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce620dd49b0b8447b5f2c20657910d4c
https://doi.org/10.1016/j.tet.2014.06.006
https://doi.org/10.1016/j.tet.2014.06.006
Publikováno v:
Chirality. 26:300-306
A series of representative optically active derivatives of 4-hydroxy-5-alkylcyclopent-2-en-1-one were prepared from the respective 2-furyl methyl carbinols via the Piancatelli rearrangement followed by the enzymatic kinetic resolution of racemates. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8a6005af659f1fb8711105a579e7883
https://doi.org/10.1002/chir.22322
https://doi.org/10.1002/chir.22322