Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice

Autor: Koji Aoyama, Fan Wang, Nobuko Matsumura, Hiroshi Kiyonari, Go Shioi, Karo Tanaka, Chisato Kinoshita, Kazue Kikuchi-Utsumi, Masahiko Watabe, Toshio Nakaki

Publikováno v: Neurobiology of Disease, Vol 45, Iss 3, Pp 973-982 (2012)

Glutathione (GSH) is an important neuroprotective molecule in the brain. The strategy to increase neuronal GSH level is a promising approach to the treatment of neurodegenerative diseases. However, the regulatory mechanism by which neuron-specific GS

Externí odkaz: https://doaj.org/article/f1b642bed8a341b693c32f1525daa974

Data from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2

Autor: Marco Giovannini, Allan E. Rubenstein, Stanley F. Nelson, Zahara M. Jaffer, Jeremie Vitte, Cory H. White, Ruihong Chen, Michiko Niwa-Kawakita, Jan Manent, Walter J. Jessen, Fabrice Chareyre, Ascia Eskin, Karo Tanaka

Purpose: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992944eb4a6ab43c00b7bc780e26e4a6
https://doi.org/10.1158/1078-0432.c.6521864.v1

Supplementary Figure 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2

Autor: Marco Giovannini, Allan E. Rubenstein, Stanley F. Nelson, Zahara M. Jaffer, Jeremie Vitte, Cory H. White, Ruihong Chen, Michiko Niwa-Kawakita, Jan Manent, Walter J. Jessen, Fabrice Chareyre, Ascia Eskin, Karo Tanaka

Supplementary Figure 1 - PDF files 5795K, Induction of apoptosis by NXD30001 in NF2-deficient cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46eea79d50f8b5c5c4fe418fbe72402a
https://doi.org/10.1158/1078-0432.22450151

Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2

Autor: Karo Tanaka, Stanley F. Nelson, Ruihong Chen, Cory H. White, Michiko Niwa-Kawakita, Jeremie Vitte, Zahara M. Jaffer, Jan Manent, Walter J. Jessen, Fabrice Chareyre, Allan E. Rubenstein, Marco Giovannini, Ascia Eskin

Publikováno v: Clinical Cancer Research. 19:3856-3870

Purpose: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c459ed806937db241e90b74a3d9ee0d5
https://doi.org/10.1158/1078-0432.ccr-12-3167

Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule

Autor: Erik Ilsø Christensen, Danièle Dubois-Laforgue, Eric Olinger, Olivier Devuyst, Pierre J. Courtoy, Jean-Philippe Lengelé, Renata Kozyraki, Sara Terryn, Marco Pontoglio, Serge Garbay, Patrick Van Der Smissen, José Timsit, Christine Bellanné-Chantelot, Karo Tanaka

Publikováno v: Terryn, S, Tanaka, K, Lengelé, J-P, Olinger, E, Dubois-Laforgue, D, Garbay, S, Kozyraki, R, Van Der Smissen, P, Christensen, E I, Courtoy, P J, Bellanné-Chantelot, C, Timsit, J, Pontoglio, M & Devuyst, O 2016, ' Tubular proteinuria in patients with HNF1α mutations : HNF1α drives endocytosis in the proximal tubule ', Kidney International. Supplement, vol. 89, no. 5, pp. 1075-89 . https://doi.org/10.1016/j.kint.2016.01.027
Kidney Int

Hepatocyte nuclear factor 1α (HNF1α) is a transcription factor expressed in the liver, pancreas, and proximal tubule of the kidney. Mutations of HNF1α cause an autosomal dominant form of diabetes mellitus (MODY-HNF1A) and tubular dysfunction. To g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c615296dfc5a1bdea5efbddc7762f0
https://www.zora.uzh.ch/id/eprint/133262/