Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karnyart Samnuan"'
Autor:
Kai Hu, Elena Palmieri, Karnyart Samnuan, Beatrice Ricchetti, Davide Oldrini, Paul F. McKay, Guanghui Wu, Leigh Thorne, Anthony R. Fooks, Lorraine M. McElhinney, Hooman Goharriz, Megan Golding, Robin J. Shattock, Francesca Micoli
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Vaccine platforms enable fast development, testing, and manufacture of more affordable vaccines. Here, we evaluated Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles (OMVs) generated by genetically modified Gram‐neg
Externí odkaz:
https://doaj.org/article/3e33e179ad1444a98db2c352043795a8
Autor:
Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine perfo
Externí odkaz:
https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d
Autor:
Damien van de Berg, Zoltán Kis, Carl Fredrik Behmer, Karnyart Samnuan, Anna K. Blakney, Cleo Kontoravdi, Robin Shattock, Nilay Shah
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Rapid-response vaccine production platform technologies, including RNA vaccines, are being developed to combat viral epidemics and pandemics. A key enabler of rapid response is having quality-oriented disease-agnostic manufacturing protocols
Externí odkaz:
https://doaj.org/article/07c8cff71bf445a6a6254505e668c398
Autor:
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immun
Externí odkaz:
https://doaj.org/article/c597076c7d2d40ebbde634f539a11f55
Autor:
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in conval
Externí odkaz:
https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
Autor:
Rebecca Frise, Laury Baillon, Jie Zhou, Ruthiran Kugathasan, Thomas P. Peacock, Jonathan C. Brown, Karnyart Samnuan, Paul F. McKay, Robin J. Shattock, Wendy S. Barclay
Publikováno v:
Vaccine. 40:2848-2855
Vaccines for SARS-CoV-2 have been hugely successful in alleviating hospitalization and deaths caused by the newly emerged coronavirus that is the cause of COVID. However, although the parentally administered vaccines are very effective at reducing se
Autor:
Molly M. Stevens, Paul Rogers, Kai Hu, Robin J. Shattock, Krunal Polra, Andrew Geall, Jonathan Yeow, Anna K. Blakney, Yunqing Zhu, Paul F. McKay, Andrew F. Brown, Karnyart Samnuan, Nikita Jain, Hadijatou Sallah, Anitha Thomas
Publikováno v:
Journal of Controlled Release
Self-amplifying RNA (saRNA) is a next-generation vaccine platform, but like all nucleic acids, requires a delivery vehicle to promote cellular uptake and protect the saRNA from degradation. To date, delivery platforms for saRNA have included lipid na
Autor:
Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Leon R. McFarlane, Jessica O'Hara, Nana-Marie Lemm, Paul McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David Dunn, Sheena McCormack, Robin J. Shattock, Kirsty Adams, Fahimah Amini, Nafisah B Atako, Amalina Bakri, Wendy Barclay, Elizabeth Brodnicki, Jonathan C Brown, Ruth Byrne, Rowena Chilvers, Sofia Coelho, Suzanne Day, Monica Desai, Eleanor Dorman, Tamara Elliott, Katie E Flight, James Fletcher, John Galang, Jagruti Gohil, Aneta Gupta, Chris Harlow, Kai Hu, Mohini Kalyan, Dominic Lagrue, Ely Liscano, Cecilia Njenga, Krunal Polra, Derecia A Powlette, Paul Randell, Mary Rauchenberger, Ianto Redknap, Maravic Ricamara, Paul Rogers, Hadijatou Sallah, Karnyart Samnuan, Michael Schumacher, Zareena Shah, Rachel Shaw, Thomas Shaw, Stefan Sivapatham, Susie Slater, Kim Sorley, Regina Storch, Elizabeth Tan, Tricia Tan, Lieze Thielemans, Sarah Whitely, Charlotte Valentine, Jeeva Varghese, Asha Vikraman, Martin Wilkins
Publikováno v:
EClinicalMedicine, Vol 44, Iss, Pp 101262-(2022)
EClinicalMedicine
EClinicalMedicine
Summary: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate LNP-nCoVsaR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28acc41920bce70d4d6595fa69b972ce
https://eprints.soton.ac.uk/455190/
https://eprints.soton.ac.uk/455190/
Autor:
Wendy S. Barclay, Kai Hu, Anna K. Blakney, Paulo J. C. Lin, Christopher Barbosa, Jonathan C Brown, Karnyart Samnuan, Jie Zhou, Ying K. Tam, Robin J. Shattock, Paul F. McKay, Paul Rogers, Rebecca Penn, Clément R. Bouton, Krunal Polra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanopar
Autor:
Alita Kongchanagul, Pilaipan Puthavathana, Karnyart Samnuan, Kobporn Boonnak, Ponthip Wirachwong, Punnee Pitisuttithum, Somchaiya Surichan
Publikováno v:
Vaccine. 38:852-858
The emergence and spread of highly pathogenic avian influenza (H5N1) viruses have raised global concerns of a possible human pandemic, spurring efforts towards H5N1 influenza vaccine development and improvements in vaccine administration methods. We