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Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

Autor: Klarin D; Veterans Affairs (VA) Palo Alto Healthcare System, Palo Alto, CA, USA. dklarin@stanford.edu.; Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA. dklarin@stanford.edu., Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Sendamarai AK; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Angueira AR; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Shen YH; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Pirruccello JP; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Karnam PR; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Li Y; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA., Wang M; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Aragam KG; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Paruchuri K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zuber V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK., Shakt GE; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tsao NL; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Judy RL; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Vy HMT; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Verma SS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rader DJ; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Do R; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bavaria JE; Division of Cardiovascular Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nadkarni GN; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Burgess S; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Guo DC; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA., LeMaire SA; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA., Milewicz DM; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsao PS; Veterans Affairs (VA) Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford, CA, USA., Pyarajan S; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Jul; Vol. 55 (7), pp. 1106-1115. Date of Electronic Publication: 2023 Jun 12.