Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Karnail S. Atwal"'
Autor:
Dezhi Xing, John Lloyd, Karnail S. Atwal, Mei Mann Hsueh, Yolanda Caringal, Ruth R. Wexler, Alexander Kover, Paul Levesque, Ji Jiang, Timothy W. Harper, Mary Lee Conder, Heather Finlay, Michael A. Blanar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1743-1747
Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e51799a21b73f50199fc9a444acca4
https://doi.org/10.1016/j.bmcl.2013.01.064
https://doi.org/10.1016/j.bmcl.2013.01.064
Autor:
Zheming Ruan, S. M. Seiler, Herbert E. Klei, Jing Zhang, Jeffrey A. Robl, Stephen P. O'connor, Mengxiao Shi, Liang Schweizer, John E. Macor, R. Michael Lawrence, Karnail S. Atwal, William A. Schumacher, Eddie C.-K. Liu, Sharon N. Bisaha, Doree F. Sitkoff, Ying Wang, Chi Li, Thomas E. Steinbacher, Yan Shi, Philip D. Stein, Kevin Kish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7516-7521
The design, synthesis and SAR of a novel class of valerolactam-based arylsulfonamides as potent and selective FXa inhibitors is reported. The arylsulfonamide-valerolactam scaffold was derived based on the proposed bioisosterism to the arylcyanoguanid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bb84aabdb3a646b55d279059af6aab
https://doi.org/10.1016/j.bmcl.2011.06.098
https://doi.org/10.1016/j.bmcl.2011.06.098
Autor:
Danshi Li, Karnail S. Atwal, Mary Lee Conder, Lin Yan, John Lloyd, Tonya Jenkins-West, Bhandaru Rao S, Huabin Sun, Tram Hyunh, Hong Shi, Alexander Kover, Paul Levesque, Wayne Vacarro, Heather Finlay, Christine Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1436-1439
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387e137fe81f63c81b84245a71aaceaf
https://doi.org/10.1016/j.bmcl.2009.12.085
https://doi.org/10.1016/j.bmcl.2009.12.085
Autor:
Joseph Yanchunas, Eddie C.-K. Liu, Christine Huang, S. M. Seiler, Yan Shi, Ying Wang, Karnail S. Atwal, Thomas E. Steinbacher, Doree F. Sitkoff, Andrew T. Pudzianowski, William A. Schumacher, Karen S. Hartl, Sharon N. Bisaha, Chi Li, Stephen P. O'connor, Kevin Kish, Mengxiao Shi, Philip D. Stein, Herbert E. Klei, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6882-6889
We report the design and synthesis of a novel class of N,N'-disubstituted aroylguanidine-based lactam derivatives as potent and orally active FXa inhibitors. The structure-activity relationships (SAR) investigation led to the discovery of the nicotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f30912ce064e83f0929d53206bf34b3
https://doi.org/10.1016/j.bmcl.2009.10.084
https://doi.org/10.1016/j.bmcl.2009.10.084
Autor:
Karnail S. Atwal, Michael Nyman, Paul Levesque, Mary Lee Conder, John Lloyd, Heather Finlay, Tonya West
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2714-2718
The design and synthesis of a series of highly functionalized pyrano-[2,3b]-pyridines is described. These compounds were assayed for their ability to block the IKur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24487e232e76e8ee94816eaebc0111b3
https://doi.org/10.1016/j.bmcl.2008.03.026
https://doi.org/10.1016/j.bmcl.2008.03.026
Autor:
David P. Rotella, Robert Zahler, David J. Augeri, Timur Gungor, Aiying Wang, William S. Slusarchyk, Scott A. Bolton, James C. Sutton, Jeffrey A. Robl, Zulan Pi, Karnail S. Atwal, Ligaya M. Simpkins, Yajun Liu, Chet Kwon, Lawrence G. Hamann, Rex A. Parker, Guohua Zhao, Mark S. Kirby, Zhong Sun, David R. Magnin, Jovita Marcinkeviciene, James G. Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6476-6480
The synthesis and structure–activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc358df323e8065d6c640de03adf2c4
https://doi.org/10.1016/j.bmcl.2007.09.090
https://doi.org/10.1016/j.bmcl.2007.09.090
Autor:
Wei Han, Patrick Y.S. Lam, Philip D. Stein, John E. Macor, Jing Zhang, Robert Zahler, Eddie C.-K. Liu, Karnail S. Atwal, Yan Shi, Ying Wang, Saleem Ahmad, Lawrence J. Kennedy, Stephen P. O'connor, S. M. Seiler, Jeffrey A. Robl, Zilun Hu, Doree F. Sitkoff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5952-5958
The design and synthesis of a novel class of amino(methyl) pyrrolidine-based sulfonamides as potent and selective FXa inhibitors is reported. The amino(methyl) pyrrolidine scaffolds were designed based on the proposed bioisosterism to the piperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b9e6828f23d93787599d46256af2d5
https://doi.org/10.1016/j.bmcl.2007.07.063
https://doi.org/10.1016/j.bmcl.2007.07.063
Autor:
Thomas M. Monticello, Paul G. Sleph, Karnail S. Atwal, Gary J. Grover, Feng-Li Wang, David W. Green, Hossain Monshizadegan
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H1747-H1755
Mitochondrial F1F0-ATPase normally synthesizes ATP in the heart, but under ischemic conditions this enzyme paradoxically causes ATP hydrolysis. Nonselective inhibitors of this enzyme (aurovertin, oligomycin) inhibit ATP synthesis in normal tissue but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0cd9846cade94f8180e54159082743
https://doi.org/10.1152/ajpheart.01019.2003
https://doi.org/10.1152/ajpheart.01019.2003
Autor:
Gary J. Grover, Francis N. Ferrara, Karnail S. Atwal, Paulina Wang, Paul G. Sleph, Sarah C. Traeger, David W. Green, Hossain Monshizadegan, W. Lynn Rogers
Publikováno v:
Journal of Medicinal Chemistry. 47:1081-1084
In this paper we show that 4-aryl-CH2-imidazole-substituted benzopyran compounds with 3S,4R-stereochemistry are cardioprotective by inhibiting the F1F0 mitochondrial ATP hydrolase. Compounds (e.g., 13) with 3R,4S-stereochemistry act as mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b607397f0ae37a74d4f9244dc5d895
https://doi.org/10.1021/jm030291x
https://doi.org/10.1021/jm030291x
Autor:
Saleem Ahmad, Charles R. Dorso, Gamini Chandrasena, Karnail S. Atwal, Wen Liu, Donald W. Combs, Bang-Chi Chen, Khehyong Ngu, David S. Weinstein, Mark S. Kirby, Shung C. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:177-180
Inhibition of the sodium hydrogen exchanger isoform-1 (NHE-1) has been shown to limit damage to the myocardium under ischemic conditions in animals. While most known NHE-1 inhibitors are acylguanidines, this report describes the design and synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de83e57961e82dae567a1d07d90f033c
https://doi.org/10.1016/j.bmcl.2003.09.066
https://doi.org/10.1016/j.bmcl.2003.09.066