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A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate.

Autor: Gilio AK; Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K., Thorpe TW; School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K., Heyam A; Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K., Petchey MR; Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K., Pogrányi B; Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K., France SP; Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States., Howard RM; Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States., Karmilowicz MJ; Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States., Lewis R; Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States., Turner N; School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K., Grogan G; Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.

Publikováno v: ACS catalysis [ACS Catal] 2023 Jan 12; Vol. 13 (3), pp. 1669-1677. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin.

Autor: Midelfort KS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA. Midelfort@msoe.edu, Kumar R, Han S, Karmilowicz MJ, McConnell K, Gehlhaar DK, Mistry A, Chang JS, Anderson M, Villalobos A, Minshull J, Govindarajan S, Wong JW

Publikováno v: Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2013 Jan; Vol. 26 (1), pp. 25-33. Date of Electronic Publication: 2012 Sep 25.

Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.

Autor: Brodney MA; Neuroscience Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. michael.a.brodney@pfizer.com, Auperin DD, Becker SL, Bronk BS, Brown TM, Coffman KJ, Finley JE, Hicks CD, Karmilowicz MJ, Lanz TA, Liston D, Liu X, Martin BA, Nelson RB, Nolan CE, Oborski CE, Parker CP, Richter KE, Pozdnyakov N, Sahagan BG, Schachter JB, Sokolowski SA, Tate B, Van Deusen JW, Wood DE, Wood KM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2631-6. Date of Electronic Publication: 2010 Dec 30.

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

Autor: Grissmer S; Department of Physiology and Biophysics, University of California, Irvine 92717., Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG

Publikováno v: Molecular pharmacology [Mol Pharmacol] 1994 Jun; Vol. 45 (6), pp. 1227-34.