Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karla Martinez Pomier"'
Publikováno v:
JACS Au, Vol 3, Iss 12, Pp 3485-3493 (2023)
Externí odkaz:
https://doaj.org/article/73d61f1b2c6f4475bfd25ce27e796e4f
Autor:
Sebastian Himbert, Isabella Passos Gastaldo, Rashik Ahmed, Karla Martinez Pomier, Braeden Cowbrough, Dushyant Jahagirdar, Samantha Ros, Janos Juhasz, Harald D. H. Stöver, Joaquin Ortega, Giuseppe Melacini, Dawn M. E. Bowdish, Maikel C. Rheinstädter
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Novel therapeutic strategies are needed to control the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. Here, we present a protocol to anchor the SARS-CoV-2 spike (S-)protein in the cytoplasmic membranes of erythrocyte liposomes
Externí odkaz:
https://doaj.org/article/d4fb6808495a4046885f094ea635e3bb
Publikováno v:
Molecules, Vol 25, Iss 16, p 3571 (2020)
Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic
Externí odkaz:
https://doaj.org/article/f43999d6613e4273af7b4fde45369c76
Publikováno v:
Canadian Journal of Chemistry. 100:649-659
Kinases include a wide variety of valuable drug targets, but full therapeutic exploitation requires a high degree of selectivity. A promising avenue to engineer the desired kinase selectivity relies on allosteric sites. Here, we provide a focused min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12549083158eea3ee2814a8e2291dfde
https://doi.org/10.1139/cjc-2021-0359
https://doi.org/10.1139/cjc-2021-0359
Publikováno v:
Journal of molecular biology. 434(17)
The cAMP- and cGMP-dependent protein kinases (PKA and PKG) are canonically activated by the corresponding cyclic nucleotides. However, both systems are also sensitive to a wide range of non-canonical allosteric effectors, such as reactive oxygen spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb01837282d32194d03eac3eb39e4ed9
https://pubmed.ncbi.nlm.nih.gov/35427632
https://pubmed.ncbi.nlm.nih.gov/35427632
Autor:
Madoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini
Publikováno v:
The Biochemical journal. 479(7)
Allosteric pluripotency arises when the functional response of an allosteric receptor to an allosteric stimulus depends on additional allosteric modulators. Here, we discuss allosteric pluripotency as observed in the prototypical Protein Kinase A (PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35abc85ad8ac57723219dfea5b2ae1e1
https://pubmed.ncbi.nlm.nih.gov/35403669
https://pubmed.ncbi.nlm.nih.gov/35403669
Publikováno v:
Biophysical chemistry. 282
Human Serum Albumin (HSA), the most abundant protein in plasma, serves a diverse repertoire of biological functions including regulation of oncotic pressure and redox potential, transport of serum solutes, but also chaperoning of misfolded proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6146aed2815419d49bfec3c3ef545c50
https://pubmed.ncbi.nlm.nih.gov/35093643
https://pubmed.ncbi.nlm.nih.gov/35093643
Publikováno v:
The Journal of Biological Chemistry
The aberrant self-assembly of intrinsically disordered proteins (IDPs) into soluble oligomers and their interactions with biological membranes underlie the pathogenesis of numerous neurodegenerative diseases, including Alzheimer’s disease. Catechin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac23eabd9949ac0237757c1695b13624
https://pubmed.ncbi.nlm.nih.gov/34929173
https://pubmed.ncbi.nlm.nih.gov/34929173
Autor:
Chi Lee, Madoka Akimoto, Stephen Boulton, Kody Moleschi, Naeimeh Jafari, Jinfeng Huang, Yousif Alsayyed, Pascale Swanson, Jung Ah Byun, Karla Martinez Pomier, Susan S. Taylor, Giuseppe Melacini, Jason C. Del Rio, Jian Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 21
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Familial mutations of the protein kinase A (PKA) R1α regulatory subunit lead to a generalized predisposition for a wide range of tumors, from pituitary adenomas to pancreatic and liver cancers, commonly referred to as Carney complex (CNC). CNC mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0a5160850997afa07d5d4850f2b234
https://doi.org/10.1073/pnas.2024716118
https://doi.org/10.1073/pnas.2024716118
Publikováno v:
Molecules
Molecules, Vol 25, Iss 3571, p 3571 (2020)
Molecules, Vol 25, Iss 3571, p 3571 (2020)
Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547a9158811137c3197ad0149e69d0e
https://doi.org/10.3390/molecules25163571
https://doi.org/10.3390/molecules25163571