Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karla M. O'Neill"'
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Karla M. O’Neill, Rachelle E. Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E. P. Loughery, Darragh G. McArt, Colum P. Walsh
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-21 (2018)
Abstract Background DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorphic lines are tumou
Externí odkaz:
https://doaj.org/article/7e57fb3b27754544a97d8dc3fefe8286
Autor:
Adam P. Harvey, Emma Robinson, Kevin S. Edgar, Ross McMullan, Karla M. O’Neill, Matthew Alderdice, Raheleh Amirkhah, Philip D. Dunne, Barbara J. McDermott, David J. Grieve
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4406 (2020)
Pressure overload-induced left ventricular hypertrophy (LVH) is initially adaptive but ultimately promotes systolic dysfunction and chronic heart failure. Whilst underlying pathways are incompletely understood, increased reactive oxygen species gener
Externí odkaz:
https://doaj.org/article/ef53204a558b4a39aafb37d53eaa2891
Autor:
Karla M. O’Neill, David J. Grieve
Publikováno v:
Cardiovascular Drugs and Therapy.
Autor:
Karla M, O'Neill, David C, Campbell, Kevin S, Edgar, Eleanor K, Gill, Arya, Moez, Kiran J, McLoughlin, Christina L, O'Neill, Margaret, Dellett, Ciarán J, Hargey, Rawan A, Abudalo, Michael, O'Hare, Philip, Doyle, Tinrui, Toh, Joshua, Khoo, June, Wong, Cian M, McCrudden, Marco, Meloni, Coy, Brunssen, Henning, Morawietz, Mervin C, Yoder, Denise M, McDonald, Chris J, Watson, Alan W, Stitt, Andriana, Margariti, Reinhold J, Medina, David J, Grieve
Publikováno v:
Cardiovascular research. 116(2)
Cord blood-derived endothelial colony-forming cells (CB-ECFCs) are a defined progenitor population with established roles in vascular homeostasis and angiogenesis, which possess low immunogenicity and high potential for allogeneic therapy and are hig
Autor:
Emma, Robinson, Mitchel, Tate, Samuel, Lockhart, Claire, McPeake, Karla M, O'Neill, Kevin S, Edgar, Danielle, Calderwood, Brian D, Green, Barbara J, McDermott, David J, Grieve
Publikováno v:
Cardiovascular Diabetology
Background Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor activation, the metabolically-i