Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Karla M. Acevedo"'
Autor:
Ashley I. Bush, Irene Volitakis, Scott Ayton, Peter J. Crouch, Adam Southon, Abdel A. Belaidi, Kevin J. Barnham, Karla M. Acevedo, Kathryn Szostak, Paul S. Donnelly, Krista A. Dent
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Diacetyl‐bis(4‐methyl‐3‐thiosemicarbazonato)copper(II) (Cu(II)(atsm)) ameliorates neurodegeneration and delays disease progression in mouse models of amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d2a8f9fcc7db5e337e7454ff9984bc
https://europepmc.org/articles/PMC7012947/
https://europepmc.org/articles/PMC7012947/
Publikováno v:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 24(8)
Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including neurotransmitter synthesis and release, neurotransmission, and protein turnover. Cu and Fe are tigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803a430e2bf83b883444779d40665965
https://pubmed.ncbi.nlm.nih.gov/31650248
https://pubmed.ncbi.nlm.nih.gov/31650248
Autor:
Lars M. Ittner, Peter J. Crouch, Shu Yang, Alexandra Grubman, Anthony R. White, Mercedes Prudencio, Ian P. Blair, Clare Duncan, Donia M Moujalled, Aphrodite Caragounis, Diane Moujalled, Yazi D. Ke, Nirma D Perera, Leonard Petrucelli, Bradley J. Turner, Jeffrey R. Liddell, Karla M. Acevedo
Publikováno v:
Human molecular genetics. 26(9)
TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Our previous studies foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578621a72ec5cb02675a6eabf5ce5078
https://pubmed.ncbi.nlm.nih.gov/28334913
https://pubmed.ncbi.nlm.nih.gov/28334913
Autor:
Leesa M. Challis, David Norrish, Ashley I. Bush, Anthony R. White, Qiao-Xin Li, James Camakaris, Carlos Opazo, Karla M. Acevedo
Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics through the secretory pathway. We have previously reported that copper promotes a change i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f029b43f9ad9b9093419c76f6c43835c
https://europepmc.org/articles/PMC4036242/
https://europepmc.org/articles/PMC4036242/
Autor:
Karla M. Acevedo, Krutika Wikhe, Blaine R. Roberts, Katrina M. Laughton, Ya Hui Hung, James Camakaris, Colin L. Masters, Alan Rembach, Andrew H. Dalziel, Ashley I. Bush, Qiao-Xin Li
Publikováno v:
The Journal of biological chemistry. 286(10)
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e599d0d2d8c2518e98a0584b0c9f6
https://pubmed.ncbi.nlm.nih.gov/21177866
https://pubmed.ncbi.nlm.nih.gov/21177866