Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Karla M, Neugebauer"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-17 (2024)
ABSTRACTPost-transcriptional regulation by RNA binding proteins can determine gene expression levels and drive changes in cancer cell proteomes. Identifying mechanisms of protein-RNA binding, including preferred sequence motifs bound in vivo, provide
Externí odkaz:
https://doaj.org/article/b1f47f7f15064385800aa7e8b7a20a9a
Autor:
Edward Courchaine, Sara Gelles-Watnick, Martin Machyna, Korinna Straube, Sarah Sauyet, Jade Enright, Karla M. Neugebauer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Cajal bodies are membraneless organelles scaffolded by coilin protein. Here, coilin–coilin and coilin–Nopp140 interaction sites are identified and perturbed, revealing coilin’s capacity to form long fibrils and be remodeled into spherical struc
Externí odkaz:
https://doaj.org/article/7eeb5d4cbc71440580714fc8aff5e6da
Autor:
Kevin Chen, Yaya Guo, Kenneth How, Arianny Acosta, Diane Documet, Cathleen Liang, Deborah Arul, Sasha Wood, Katherine Moon, Lilijana S. Oliver, Emely Lopez Fajardo, Miriam Kopyto, Morgan Shine, Karla M Neugebauer
Publikováno v:
BBA Advances, Vol 4, Iss , Pp 100111- (2023)
Global warming is caused by human activity, such as the burning of fossil fuels, which produces high levels of greenhouse gasses. As a consequence, climate change impacts all organisms and the greater ecosystem through changing conditions from weathe
Externí odkaz:
https://doaj.org/article/62a79b4d856d47d2a769ff8466d5f61f
Autor:
Prajwal C. Boddu, Abhishek K. Gupta, Jung-Sik Kim, Karla M. Neugebauer, Todd Waldman, Manoj M. Pillai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Boddu et al combined AAV-intron trap, CRISPR/Cas9 and inducible Cre-recombinase systems to introduce the oncogenic K700E mutation in SF3B1, which is a splicing factor commonly mutated in multiple cancers, with more than 90% efficiency. Their approach
Externí odkaz:
https://doaj.org/article/a82081c24935453796100f3eab74b879
Autor:
Austin S. Draycott, Cassandra Schaening-Burgos, Maria F. Rojas-Duran, Loren Wilson, Leonard Schärfen, Karla M. Neugebauer, Sigrid Nachtergaele, Wendy V. Gilbert
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine sequencing (D-seq) for transcriptome-wide mapping of D with single-nucleotide reso
Externí odkaz:
https://doaj.org/article/cc529fc7d66c41c0bd44aeb22d3d881d
Autor:
Leonard Schärfen, Dagmar Zigackova, Kirsten A. Reimer, Martha R. Stark, Viktor A. Slat, Nancy J. Francoeur, Melissa L. Wells, Lecong Zhou, Perry J. Blackshear, Karla M. Neugebauer, Stephen D. Rader
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Alternative polyadenylation (APA) is widespread among metazoans and has been shown to have important impacts on mRNA stability and protein expression. Beyond a handful of well-studied organisms, however, its existence and consequences have not been w
Externí odkaz:
https://doaj.org/article/102645cef62646d1ae3cbf4698f7fb79
Publikováno v:
Trends in Biochemical Sciences.
Autor:
Andrew E S Barentine, Yu Lin, Edward M Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R Grace, Zach Marin, Mark Lessard, Juliana Rios Chen, Siyuan Wang, Karla M Neugebauer, Joerg Bewersdorf, David Baddeley
Publikováno v:
Nature Biotechnology.
Diffraction-unlimited single-molecule techniques like STORM and (F)PALM enable three-dimensional (3D) fluorescence imaging at tens of nanometer resolution and are invaluable to investigate sub-cellular organization. The multitude of camera frames req
Autor:
Prajwal C Boddu, Abhishek Gupta, Rahul Roy, Barbara De La Pena Avalos, Ane Olazabal Herrero, Nils Neuenkirchen, Josh Zimmer, Namrata Chandhok, Darren King, Yashuhito Nannya, Seishi Ogawa, Haifan Lin, Matthew Simon, Eloise Dray, Gary Kupfer, Amit K. Verma, Karla M. Neugebauer, Manoj M Pillai
Publikováno v:
bioRxiv
Transcription and splicing of pre-messenger RNA are closely coordinated, but how this functional coupling is disrupted in human disease remains unexplored. Here, we investigated the impact of non-synonymous mutations in SF3B1 and U2AF1, two commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc52bc1a58f7506bad42b4fd807506b
https://europepmc.org/articles/PMC9994134/
https://europepmc.org/articles/PMC9994134/
Autor:
Kirsten A. Reimer, Karla M. Neugebauer
Publikováno v:
F1000Research, Vol 7 (2018)
During erythropoiesis, hematopoietic stem and progenitor cells transition to erythroblasts en route to terminal differentiation into enucleated red blood cells. Transcriptome-wide changes underlie distinct morphological and functional characteristics
Externí odkaz:
https://doaj.org/article/d29f696f5e2c499b9530c6379b46fb62