Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Karla Lehle"'
Autor:
Maria S. Wagner, Michael Kranz, Lars Krenkel, Daniel Pointner, Maik Foltan, Matthias Lubnow, Karla Lehle
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Extracorporeal membrane oxygenation (ECMO) was established as a treatment for severe cardiac or respiratory disease. Intra-device clot formation is a common risk. This is based on complex coagulation phenomena which are not yet sufficiently understoo
Externí odkaz:
https://doaj.org/article/27904dacf6054c2b874aa5ad9f12f9e7
Autor:
Moritz Haus, Maik Foltan, Alois Philipp, Thomas Mueller, Michael Gruber, Maximilian P. Lingel, Lars Krenkel, Karla Lehle
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Neutrophil extracellular traps (NETs) have recently emerged as a potential link between inflammation, immunity, and thrombosis, as well as other coagulation disorders which present a major challenge in the context of extracorporeal membrane oxygenati
Externí odkaz:
https://doaj.org/article/1a7c04048098491d9636dd2d8ce1966b
Autor:
Matthias Lubnow, Johannes Berger, Roland Schneckenpointner, Florian Zeman, Dirk Lunz, Alois Philipp, Maik Foltan, Karla Lehle, Susanne Heimerl, Christina Hart, Christof Schmid, Christoph Fisser, Thomas Müller
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272577 (2022)
ObjectivesUnfractionated heparin (UFH) is the commonly used anticoagulant to prevent clotting of the ECMO circuit and thrombosis of the cannulated vessels. A side effect of UFH is heparin-induced thrombocytopenia (HIT). Little is known about HIT duri
Externí odkaz:
https://doaj.org/article/537eb9ffbc1943aa9202cbc79dc7ceb3
Autor:
Tamara Steiger, Alois Philipp, Karl-Anton Hiller, Thomas Müller, Matthias Lubnow, Karla Lehle
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248645 (2021)
ObjectiveFailure of membrane oxygenator (MO) function of venovenous extracorporeal membrane oxygenators (VV ECMO) remains problematic. The development of device-induced coagulation disorder (COD) or worsened gas transfer (WGT) necessitates a system e
Externí odkaz:
https://doaj.org/article/d7a9d69c40e146d98b4eaf87f822caaa
Autor:
Hannah Appelt, Alois Philipp, Thomas Mueller, Maik Foltan, Matthias Lubnow, Dirk Lunz, Florian Zeman, Karla Lehle
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227793 (2020)
Venovenous (VV) and venoarterial (VA) extracorporeal membrane oxygenation (ECMO) are effective support modalities to treat critically ill patients. ECMO-associated hemolysis remains a serious complication. The aim was to disclose similarities and dif
Externí odkaz:
https://doaj.org/article/8a0ae397733c4bdabefe5860442b3d0b
Autor:
Andre Bredthauer, Manuel Kopfmueller, Michael Gruber, Sophie-Marie Pfaehler, Karla Lehle, Walter Petermichl, Timo Seyfried, Diane Bitzinger, Andreas Redel
Publikováno v:
Cardiovascular Therapeutics, Vol 2020 (2020)
Introduction. Anticoagulants such as argatroban and heparins (low-molecular-weight and unfractionated) play an immense role in preventing thromboembolic complications in clinical practice. Nevertheless, they can also have a negative effect on the imm
Externí odkaz:
https://doaj.org/article/22234ea6a8b54356810d95c976110253
Autor:
Delou Pai, Michael Gruber, Sophie-Marie Pfaehler, Andre Bredthauer, Karla Lehle, Benedikt Trabold
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Chemotaxis and the formation of suicidal neutrophil extracellular traps (suicidal NETosis) are key functions of polymorphonuclear cells (PMNs). Neutrophil extracellular traps in particular are known to be significantly involved in the severity of inf
Externí odkaz:
https://doaj.org/article/7a4a940ea61e419db2b19afc8dd40681
Autor:
Andre Bredthauer, Karla Lehle, Angelika Scheuerle, Hubert Schelzig, Oscar McCook, Peter Radermacher, Csaba Szabo, Martin Wepler, Florian Simon
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Objective In rodents, intravenous sulfide protected against spinal cord ischemia/reperfusion (I/R) injury during aortic balloon occlusion. We investigated the effect of intravenous sulfide on aortic occlusion-induced porcine spinal cord I/R
Externí odkaz:
https://doaj.org/article/b5008412a9114809a4eb502b1fce41be
Autor:
Matthias Hattenkofer, Michael Gruber, Sophia Metz, Sophie-Marie Pfaehler, Karla Lehle, Benedikt Trabold
Publikováno v:
European Journal of Inflammation, Vol 16 (2018)
Polymorphonuclear cells (PMNs) attend to inflammatory sites by chemotactic movement, caused by chemoattractants (CAs) like n-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) and interleukin-8 (IL-8). However, distinct but applicable assays for inve
Externí odkaz:
https://doaj.org/article/25ca2ad0b9534fd6a46ca693356c67bb
Autor:
Alois Philipp, Filip De Somer, Maik Foltan, Andre Bredthauer, Lars Krenkel, Florian Zeman, Karla Lehle
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198392 (2018)
Over the past decade, veno-venous extracorporeal membrane oxygenation (vvECMO) has been increasingly utilized in respiratory failure in patients. This study presents our institution´s experience focusing on the life span of ECMO systems reflecting t
Externí odkaz:
https://doaj.org/article/2221ef971cd348cfbf74a94084d87a03