Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karla L. Bretherick"'
Autor:
Karla L Bretherick, Johanna M Schuetz, Lindsay M Morton, Mark P Purdue, Lucia Conde, Richard P Gallagher, Joseph M Connors, Randy D Gascoyne, Brian R Berry, Bruce Armstrong, Anne Kricker, Claire M Vajdic, Andrew Grulich, Henrik Hjalgrim, Karin E Smedby, Christine F Skibola, Nathaniel Rothman, John J Spinelli, Angela R Brooks-Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74619 (2013)
H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by ch
Externí odkaz:
https://doaj.org/article/b77d55abdff64e28947c65e3da476dc9
Autor:
Andy G. X. Zeng, Karla L. Bretherick, Nina Thiessen, Lauren C. Tindale, Angela Brooks-Wilson, Stephen Leach
Publikováno v:
Gerontology. 62:58-62
Background: It is not understood whether long-term good health is promoted by the absence of disease risk variants, the presence of protective variants, or both. We characterized the exomes of two exceptionally healthy centenarian brothers aged 106 a
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :37-43
Due to the critical role of the H2AX histone variant in double-strand break repair, genetic variants in the H2AX gene, H2AFX , may influence cancer susceptibility. Genetic association studies have correlated H2AFX upstream variants with cancer risk;
Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage
Publikováno v:
Human Reproduction. 25:2664-2671
Background Recurrent miscarriage affects 1-2% of couples trying to conceive, and is idiopathic in nearly half. Female fertility is controlled by the hypothalamus-pituitary-ovarian (HPO) axis and we hypothesize that genetic polymorphisms affecting the
Publikováno v:
Fertility and Sterility. 93:2162-2168
Objective Female fertility declines with age; however, women are increasingly delaying childbearing until later in their reproductive years. One of the factors that may contribute to this trend is a general lack of knowledge about the decline in fert
Autor:
Margo R. Fluker, Lauren M. Currie, Wendy P. Robinson, Courtney W. Hanna, Karla L. Bretherick, Geoffrey L. Hammond
Publikováno v:
Fertility and Sterility. 89:318-324
Objective To assess the role of hormone receptor/binding protein variants in genetic predisposition to premature ovarian failure (POF). Design Case-control study. Setting Academic. Patient(s) Fifty-five POF patients, 107 control women from the genera
Publikováno v:
Cytogenetic and Genome Research. 111:260-265
Recently, we reported that skewed X chromosome inactivation (XCI) was more common in women who had experienced a trisomic pregnancy as compared to control women. Rather than an overall shift in the distribution of skewing there appears to only be an
Autor:
Joseph M. Connors, Angela Brooks-Wilson, Mark P. Purdue, Anne Kricker, Lindsay M. Morton, Karin E. Smedby, Johanna M. Schuetz, Christine F. Skibola, Brian R. Berry, Randy D. Gascoyne, Claire M. Vajdic, Henrik Hjalgrim, Bruce K. Armstrong, Andrew E. Grulich, Karla L. Bretherick, Lucia Conde, John J. Spinelli, Nathaniel Rothman, Richard P. Gallagher
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e74619 (2013)
PLoS ONE, Vol 8, Iss 9, p e74619 (2013)
H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by ch
Autor:
Jane L. Gair, Karla L. Bretherick, Margo R. Fluker, Mary D. Stephenson, Wendy P. Robinson, Courtney W. Hanna
Publikováno v:
Human Reproduction (Oxford, England)
Previous studies have suggested an association between rates of biological and reproductive aging. Short telomere length is a marker for cellular aging and may occur more frequently in women with poor oocyte quality and a history of premature reprodu
Autor:
Jean-Pierre Chanoine, Wan L. Lam, Daniel Metzger, Margo R. Fluker, Karla L. Bretherick, Carolyn J. Brown, Spencer K. Watson, Constadina Panagiotopoulos, Wendy P. Robinson
Publikováno v:
American journal of medical genetics. Part A. (9)
Premature ovarian failure (POF) is the occurrence of menopause before the age of 40, and may present with either primary or secondary amenorrhea. Numerous cases of POF in women with X-chromosome deletions or translocations have been reported; thus, i