Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Karla J. Schramm"'
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Supplementary Figure 2 from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak
PDF file - 241K, Histological analysis of LC3 spatial expression patterns in relation to pimonidazole hydrochloride (Hypoxia) and Glut1 expression. MDA-MB-231 MFP tumor was histologically stained for LC3, Glut1, and pimonidazole hydrochloride. Pixel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eb7e9cdf609d834a80106a3be4b0fc
https://doi.org/10.1158/0008-5472.22391631
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2
Supplementary Figure 3 from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak
PDF file - 431K, Histological analysis of in-vivo LC3 expression in HS766T subcutaneous tumors buffered with sodium bicarbonate. (A) Whole cell lysates from HS766T cells cultured at neutral pH 7.4 or pH 6.7 for 48 hours were analyzed for LC3-II expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5bccdfdb9906bb431380bcab3b43fe
https://doi.org/10.1158/0008-5472.22391628
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4
Data from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak
Tumor cell survival relies upon adaptation to the acidic conditions of the tumor microenvironment. To investigate potential acidosis survival mechanisms, we examined the effect of low pH (6.7) on human breast carcinoma cells. Acute low pH exposure re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b59da9ba728c46c24503129860ba359
https://doi.org/10.1158/0008-5472.c.6503307.v1
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5
Supplementary Figure 1 from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak
PDF file - 344K, (A) Reference guide for the phospho-protein array. (B) Representative fluorescent arrays for whole cell lysates from MDA-MB-231 cells cultured at pH 7.4 or pH 6.7 for 72 hours. (C-D) Quantitative analysis of fluorescence intensity fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fd77e890cfb8ab1a9bc10d1ec68df4
https://doi.org/10.1158/0008-5472.22391634
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6
Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Autor: Virendra Kumar, Jennifer M. Rothberg, Joshua B. Proemsey, Jonathan W. Wojtkowiak, Karla J. Schramm, Bonnie F. Sloane, Mark C. Lloyd, Edward M Haller, Robert J. Gillies
Publikováno v: Cancer Research. 72:3938-3947
Tumor cell survival relies upon adaptation to the acidic conditions of the tumor microenvironment. To investigate potential acidosis survival mechanisms, we examined the effect of low pH (6.7) on human breast carcinoma cells. Acute low pH exposure re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b37d5813047c13f588c463ddf8ae28b
https://doi.org/10.1158/0008-5472.can-11-3881
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7
Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
Autor: Robert J. Gillies, Daniel Verduzco, Jonathan W. Wojtkowiak, Karla J. Schramm
Publikováno v: Molecular Pharmaceutics. 8:2032-2038
Despite advances in developing novel therapeutic strategies, a major factor underlying cancer related death remains resistance to therapy. In addition to biochemical resistance, mediated by xenobiotic transporters or binding site mutations, resistanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8214fed7756d94066e7cd1d32f47f2db
https://doi.org/10.1021/mp200292c
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8
Abstract A65: Changes in protein expression related to acidosis in the tumor microenvironment
Autor: Karla J. Schramm, John M. Koomen, Umut Oguz, Robert J. Gillies, Jonathan W. Wojtkowiak, Sophie Vibet
Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 19:A65-A65
Background: Acidosis, due to poor perfusion coupled with increased glycolysis, alters the immediate tumor microenvironment; tumor cells that adapt to lower pH have a growth advantage and become more invasive leading to metastasis. The phenotypic chan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de1a0308a82ea78fe4eafa26e46d366
https://doi.org/10.1158/1055-9965.disp-10-a65
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9
Abstract B29: Training cancer researchers that are community advocates
Autor: Joel Aliancy, Danyell S. Wilson, Eric B. Haura, John M. Koomen, Nicholas J. Eustace, Karla J. Schramm, Robert J. Gillies, William S. Dalton, Kenneth H. Shain, Cathy D. Meade, Beulah D. Joseph, Bin Fang, Keiran S.M. Smalley
Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 19:B29-B29
Introduction: Eleven years ago, Moffitt Cancer Center developed Project LINK (Leaders In New Knowledge), a program that created mentoring relationships between established researchers and high school and college level students. The success of this pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07a34e2fb68241f1940de64ad2c56c8d
https://doi.org/10.1158/1055-9965.disp-10-b29
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