Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Karla J. Hutt"'
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-9 (2023)
Abstract Mammalian oocytes spend most of their life in a unique state of cell cycle arrest at meiotic prophase I, during which time they are exposed to countless DNA-damaging events. Recent studies have shown that DNA double-strand break repair occur
Externí odkaz:
https://doaj.org/article/6e3a0ec5d18f4730acd0ed98b0a61752
Autor:
Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, Karla J. Hutt
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosi
Externí odkaz:
https://doaj.org/article/5f5fb79aac544827af9939d421f1dc2e
Autor:
Meaghan J. Griffiths, Sarah A. Marshall, Fiona L. Cousins, Lauren R. Alesi, Jordan Higgins, Saranya Giridharan, Urooza C. Sarma, Ellen Menkhorst, Wei Zhou, Alison S. Care, Jacqueline F. Donoghue, Sarah J. Holdsworth-Carson, Peter A.W. Rogers, Evdokia Dimitriadis, Caroline E. Gargett, Sarah A. Robertson, Amy L. Winship, Karla J. Hutt
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Female cancer survivors are significantly more likely to experience infertility than the general population. It is well established that chemotherapy and radiotherapy can damage the ovary and compromise fertility, yet the ability of cancer treatments
Externí odkaz:
https://doaj.org/article/ee2f5e90ec17471e8dc9f94a729ae7b3
Autor:
Qiaochu Wang, Karla J. Hutt
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Background Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells t
Externí odkaz:
https://doaj.org/article/9f52c0f8f85f4aefaac91609e3469085
Publikováno v:
Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ovarian reserve. In t
Externí odkaz:
https://doaj.org/article/e92fae1583284f7d99a0e7ce18f2dff6
Autor:
Nicola D. Kolaitis, Bethany J. Finger, D. Jo Merriner, Joseph Nguyen, Brendan J. Houston, Moira K. O’Bryan, Jessica M. Stringer, Nadeen Zerafa, Ngoc Nguyen, Karla J. Hutt, Gerard A. Tarulli, Mark P. Green
Publikováno v:
Cells, Vol 12, Iss 4, p 648 (2023)
A common herbicide, atrazine, is associated with poor health. Atrazine acts as an endocrine disruptor at supra-environmental levels. Little research, however, has been conducted regarding chronic exposure to environmental atrazine concentrations acro
Externí odkaz:
https://doaj.org/article/8cd9e5dbc5724e82bdb3a848e25780d7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Ovarian aging is a natural process characterized by follicular depletion and a reduction in oocyte quality, resulting in loss of ovarian function, cycle irregularity and eventually infertility and menopause. The factors that contribute to ovarian agi
Externí odkaz:
https://doaj.org/article/2144ed2199814425ae78122c9886cfce
Autor:
Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib whi
Externí odkaz:
https://doaj.org/article/daa72fc740814394b7993401524f3f72
Publikováno v:
Reproduction. 164:V15-V18
Human genome-wide association studies and evidence from animal models link ovarian ageing to double-strand (ds)DNA break repair capacity. Is there a connection between single-strand (ss)DNA repair mechanisms and ovarian function? We hypothesize that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f54725b54fadb98ef46338f105b7f4
https://doi.org/10.1530/rep-22-0325
https://doi.org/10.1530/rep-22-0325
Autor:
Amy L. Winship, Lauren R. Alesi, Sneha Sant, Jessica M. Stringer, Aldana Cantavenera, Teharn Hegarty, Carolina Lliberos Requesens, Seng H. Liew, Urooza Sarma, Meaghan J. Griffiths, Nadeen Zerafa, Stephen B. Fox, Emmaline Brown, Franco Caramia, Pirooz Zareie, Nicole L. La Gruta, Kelly-Anne Phillips, Andreas Strasser, Sherene Loi, Karla J. Hutt
Publikováno v:
Nature Cancer. 3:1-13
Loss of fertility is a major concern for female reproductive-age cancer survivors, since a common side-effect of conventional cytotoxic cancer therapies is permanent damage to the ovary. While immunotherapies are increasingly becoming a standard of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5921ffaf7787f14ee404e6e7845c9f
https://doi.org/10.1038/s43018-022-00413-x
https://doi.org/10.1038/s43018-022-00413-x