Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Karla J Suchacki"'
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
Autor:
Karla J Suchacki, Benjamin J Thomas, Yoshiko M Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn
Publikováno v:
eLife, Vol 12 (2023)
Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased adiposity and improved insulin sensitivity, are important for its broader health benefits; however,
Externí odkaz:
https://doaj.org/article/b9038b3cadf8461faa31dbc4889698f6
Autor:
Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J. Rosen, Vicky E. MacRae, Jose Luis Millán, Colin Farquharson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulat
Externí odkaz:
https://doaj.org/article/23dc81b350d5458086f9e23af1515cc1
Autor:
Karla J. Suchacki, Adriana A. S. Tavares, Domenico Mattiucci, Erica L. Scheller, Giorgos Papanastasiou, Calum Gray, Matthew C. Sinton, Lynne E. Ramage, Wendy A. McDougald, Andrea Lovdel, Richard J. Sulston, Benjamin J. Thomas, Bonnie M. Nicholson, Amanda J. Drake, Carlos J. Alcaide-Corral, Diana Said, Antonella Poloni, Saverio Cinti, Gavin J. Macpherson, Marc R. Dweck, Jack P. M. Andrews, Michelle C. Williams, Robert J. Wallace, Edwin J. R. van Beek, Ormond A. MacDougald, Nicholas M. Morton, Roland H. Stimson, William P. Cawthorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in
Externí odkaz:
https://doaj.org/article/1d8037faca4e43bfbbf32bcfca139cb8
Autor:
Claire L. Wood, Karla J. Suchacki, Rob van ’t Hof, Will P. Cawthorn, Scott Dillon, Volker Straub, Sze Choong Wong, Syed F. Ahmed, Colin Farquharson, Annemieke Aartsma-Rus, James Dowling, Maaike van Putten
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 2 (2020)
The muscular dystrophy X-linked (mdx) mouse is commonly used as a mouse model of Duchenne muscular dystrophy (DMD). Its phenotype is, however, mild, and other mouse models have been explored. The mdx:Cmah−/− mouse carries a human-like mutation in
Externí odkaz:
https://doaj.org/article/115a85de5287469e82f3c757ce592baf
Autor:
Yoshiko M Ikushima, Benjamin J Thomas, Karla J Suchacki, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a068d96ee897a94f3927665eb5eb02d5
https://doi.org/10.7554/elife.88080.sa2
https://doi.org/10.7554/elife.88080.sa2
Autor:
Karla J Suchacki, Benjamin J. Thomas, Claire Fyfe, Adriana Tavares, Richard J. Sulston, Andrea Lovdel, Holly J. Woodward, Xuan Han, Domenico Mattiucci, Eleanor J. Brain, Carlos Jose Alcaide-Corral, Gillian A. Gray, Phillip D. Whitfield, Roland H Stimson, Nik Morton, Alexandra M. Johnstone, William P. Cawthorn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680f7508bee3b5965c4129ac59aa188a
https://doi.org/10.15252/rc.2022757889
https://doi.org/10.15252/rc.2022757889
Publikováno v:
European Journal of Endocrinology
Excessive accumulation of white adipose tissue leads to obesity and its associated metabolic health consequences such as type 2 diabetes and cardiovascular disease. Several approaches to treat or prevent obesity including public health interventions,
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
Autor:
Karla J. Suchacki, Ben J. Thomas, Yoshiko Matsumoto Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana A.S. Tavares, Richard J. Sulston, Andrea Lovdel, Holly J. Woodward, Xuan Han, Domenico Mattiucci, Eleanor J. Brain, Carlos J. Alcaide-Corral, Hiroshi Kobayashi, Gillian A. Gray, Phillip D. Whitfield, Roland H. Stimson, Nicholas M. Morton, Alexandra M. Johnstone, William P. Cawthorn
Publikováno v:
Suchacki, K, Thomas, B J, Matsumoto Ikushima, Y, Chen, K-C, Fyfe, C, Tavares, A A S, Sulston, R, Lovdel, A, Woodward, H J, Han, X, Mattiucci, D, Brain, E J, Alcaide-Corral, C J, Kobayashi, H, Gray, G A, Whitfield, P D, Stimson, R H, Morton, N M, Johnstone, A M & Cawthorn, W P 2023, ' The effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent ', eLIFE . https://doi.org/10.7554/eLife.88080
SUMMARYCaloric restriction (CR) is a nutritional intervention that reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased fat mass and improved insulin sensitivity, play an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e42ca1d20301119d82fd01a4b86df3
https://doi.org/10.1101/2022.02.20.481222
https://doi.org/10.1101/2022.02.20.481222
Autor:
Alexandra Kelman, Lynne Ramage, Roland Stimson, Joanna Simpson, Stewart Rodney, Beek Edwin van, Karla J. Suchacki, Sonia J. Wakelin, Alison Fletcher, Roderick N. Carter, Kwok T’ng Choong, Nicholas M. Morton, Natalie Z.M. Homer, Gillian Macnaught, Jonathan Manning, Matthew Keegan, Calum Gray, Ben T McNeill
Publikováno v:
Endocrine Abstracts.
Autor:
Andrew Clear, Anna Castleton, James D. Cavenagh, Heather Oakervee, Farideh Miraki-Moud, Pedro R. Cutillas, Bella Patel, Koorosh Korfi, Linda Ariza McNaughton, C. Xintaropoulou, F. Mardakheh, Dominique Bonnet, Ania Wilczynska, I. Pislariu, Ai Nagano, Michael J Austin, Martyn T. Smith, Karla J. Suchacki, John G. Gribben, Mariarita Calaminici, Q. Heydt, David Taussig, B. Peck, William P. Cawthorn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Heydt, Q, Xintaropoulou, C, Clear, A, Austin, M, Pislariu, I, Miraki-Moud, F, Cutillas, P, Korfi, K, Calaminici, M, Cawthorn, W P, Oldknow, K, Nagano, A, Gribben, J G, Smith, M, Cavenagh, J D, Oakervee, O, Castleton, A, Taussig, D, Peck, B, Wilczynska, A, McNaughton, L, Bonnett, D, Mardakheh, F & Patel, B 2021, ' Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence ', Nature Communications . https://doi.org/10.1038/s41467-021-25540-4
Nature Communications
Heydt, Q, Xintaropoulou, C, Clear, A, Austin, M, Pislariu, I, Miraki-Moud, F, Cutillas, P, Korfi, K, Calaminici, M, Cawthorn, W P, Oldknow, K, Nagano, A, Gribben, J G, Smith, M, Cavenagh, J D, Oakervee, O, Castleton, A, Taussig, D, Peck, B, Wilczynska, A, McNaughton, L, Bonnett, D, Mardakheh, F & Patel, B 2021, ' Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence ', Nature Communications . https://doi.org/10.1038/s41467-021-25540-4
The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show that Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c220a94fddf24cc1f0df4340c2278b
https://eprints.gla.ac.uk/252357/1/252357.pdf
https://eprints.gla.ac.uk/252357/1/252357.pdf