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Akademický článek

Evaluation of inflammation and follicle depletion during ovarian ageing in mice

Autor: Carolina Lliberos, Seng H. Liew, Pirooz Zareie, Nicole L. La Gruta, Ashley Mansell, Karla Hutt

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Reproductive ageing in females is defined by a progressive decline in follicle number and oocyte quality. This is a natural process that leads to the loss of fertility and ovarian function, cycle irregularity and eventually menopause or repr

Externí odkaz: https://doaj.org/article/ccf2ef3a52fb47d880669b6ed595328e

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Akademický článek

Smchd1 is a maternal effect gene required for genomic imprinting

Autor: Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andrés Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt

Publikováno v: eLife, Vol 9 (2020)

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report e

Externí odkaz: https://doaj.org/article/e994c277b0c146169eb4f3f1fb17b649

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Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss

Autor: Kelly L Walton, Monica P Goney, Zoe Peppas, Jessica M Stringer, Amy Winship, Karla Hutt, Georgia Goodchild, Shreya Maskey, Karen L Chan, Emilie Brûlé, Daniel J Bernard, William A Stocker, Craig A Harrison

Publikováno v: Endocrinology. 163(4)

Inhibins are members of the transforming growth factor-β family, composed of a common α-subunit disulfide-linked to 1 of 2 β-subunits (βA in inhibin A or βB in inhibin B). Gonadal-derived inhibin A and B act in an endocrine manner to suppress th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74744ccb704f916802028cd56a6d5774
https://pubmed.ncbi.nlm.nih.gov/35255139

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