Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karla D. Thrall"'
Autor:
Se-Ran Jun, Marjan Boerma, Zulema Udaondo, Sasha Richardson, Karla D. Thrall, Isabelle R. Miousse, John Seng, Rupak Pathak, Martin Hauer-Jensen
Publikováno v:
Metabolites, Vol 11, Iss 8, p 540 (2021)
The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependent changes i
Externí odkaz:
https://doaj.org/article/debcbe541b9b43d6826e90aa3a23a680
Autor:
Simon Authier, Francis Herodin, Melanie Doyle-Eisele, Michel Drouet, Karla D. Thrall, Jean-Marc Bertho, Ann M. Farese, Thomas J. MacVittie
Publikováno v:
Health physics. 121(4)
Medical countermeasure development under the US Food and Drug Administration animal rule requires validated animal models of acute radiation effects. The key large animal model is the non-human primate, rhesus macaque. To date, only the rhesus macaqu
Autor:
Martin Hauer-Jensen, Karla D Thrall, John E. Seng, Rupak Pathak, Isabelle R. Miousse, Marjan Boerma, Se-Ran Jun, Sasha Richardson, Zulema Udaondo
Publikováno v:
Metabolites
Volume 11
Issue 8
Metabolites, Vol 11, Iss 540, p 540 (2021)
Volume 11
Issue 8
Metabolites, Vol 11, Iss 540, p 540 (2021)
The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependent changes i
Autor:
M.K. Jackson, William E. Jackson, Thomas J. MacVittie, Ann M. Farese, Karla D. Thrall, Saikanth Mahendra
Publikováno v:
Health Physics. 116:354-365
Radiation-induced lung injury is a characteristic, dose- and time-dependent sequela of potentially lethal, delayed effects of acute radiation exposure. Understanding of these delayed effects to include development of medical countermeasures requires
Publikováno v:
International journal of radiation biology. 97(sup1)
Total body irradiation of the Gottingen minipig results in a characteristic hematopoietic response, including anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Currently, there are no well-characterized large or small animal models for radi
Autor:
Espoir M. Kyubwa, Saikanth Mahendra, Thomas A. Miller, Karla D. Thrall, Jason Yamada-Hanff, Seth Wallack, Naresh Menon, Mark A. Starbird, Claude J. Rogers, Asa A. Phelps, Agnes I. Lukaszewicz
Publikováno v:
Radiation research. 196(5)
Thoracic exposure to ionizing radiation can lead to delayed injuries to the heart and lung that are serious and even life-threatening. These injuries are difficult to predict since they manifest over many weeks and months. To identify noninvasive, ti
Autor:
Anirudh Chaturvedi, Jamie Lovaglio, Karla D. Thrall, Mayur Mundada, Mark K. Murphy, Renee N. Cataneo, Michael Phillips, Urvish Patel
Publikováno v:
Health physics. 105(3)
There is a great deal of interest in the establishment of a standardized animal model for the acute radiation syndrome to allow development of diagnostic approaches and countermeasure treatments following radiological terrorist events. Due to physiol
Publikováno v:
Expert Opinion on Drug Discovery. 11:1131-1134
For drug development and approval by regulatory agencies, data from rodent and non-rodent animal models are required; canines and nonhuman primates (NHPs) have been the species of choice as non-rod...
Autor:
Tatiana G. Levitskaia, Teresa Luders, Jeffrey A. Creim, Karla D. Thrall, Samuel A. Bryan, James M. Peterson, Terry L. Curry
Publikováno v:
Drug Development Research. 73:252-273
In the event of an intentional or accidental release of ionizing radiation in a densely populated area, timely assessment and triage of the general population for the radiation exposure is critical. In particular, a significant number of the victims
Autor:
Jeffrey A. Creim, Barry Levinson, Karla D. Thrall, Teresa Luders, James M. Peterson, Terry L. Curry, Tatiana G. Levitskaia
Publikováno v:
Health Physics. 101:118-127
Cuprimine® and Syprine® are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation and accelerated excretion of internally-deposited copper. These oral therapeutics are base