Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Karla C. Williams"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The development of successful treatment regimens for breast cancer requires strong pre-clinical data generated in physiologically relevant pre-clinical models. Here we report the development of the chick embryo chorioallantoic membrane (CAM)
Externí odkaz:
https://doaj.org/article/5143e5409bbd495eb8b697efc3164fe1
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Protein glycosylation, the attachment of carbohydrates onto proteins, is a fundamental process that alters the biological activity of proteins. Changes to glycosylation states are associated with many forms of cancer including breast cancer.
Externí odkaz:
https://doaj.org/article/cb23195f89574b36b7e544d22c1a6ce2
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106305- (2023)
Summary: Metastatic lesions produced through the process of systemic tumor cell dissemination and growth at distant sites are challenging to treat and the primary cause of patient mortality. Developing in vivo models of metastasis with utility in eva
Externí odkaz:
https://doaj.org/article/e249c26b8b754d30a206956d1cb89d07
Autor:
Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N. Kitova, Fahima Mozaneh, Gour Daskhan, Edward N. Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D. St. Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J. West, Karla C. Williams, John S. Klassen, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, wh
Externí odkaz:
https://doaj.org/article/c0a8a14897d44e9db090036236f8b1ee
Autor:
Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page
Publikováno v:
Metabolites, Vol 13, Iss 2, p 151 (2023)
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinic
Externí odkaz:
https://doaj.org/article/dc113ce5c5ce4058bae4c79c8ea7ac25
Autor:
Hai-Feng Zhang, Alberto Delaidelli, Sumreen Javed, Busra Turgu, Christopher S. Hughes, Xiaqiu Yang, Michael Lizardo, Daniel Martinez, John M. Maris, Kristopher R. Bosse, Karla C. Williams, Poul H. Sorensen
Publikováno v:
Cancer Research. 83:2593-2593
MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) that predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to aggressiveness in MNA+ NB remains poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953923c200d34e9a181a5eba21dbaa7a
https://doi.org/10.1158/1538-7445.am2023-2593
https://doi.org/10.1158/1538-7445.am2023-2593
Publikováno v:
NPJ breast cancer. 8(1)
Protein glycosylation, the attachment of carbohydrates onto proteins, is a fundamental process that alters the biological activity of proteins. Changes to glycosylation states are associated with many forms of cancer including breast cancer. Through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870637cc77e9b4ceba36b7ce250f4aaf
https://pubmed.ncbi.nlm.nih.gov/35780131
https://pubmed.ncbi.nlm.nih.gov/35780131
Autor:
Milica Krstic, Joseph Torchia, Connor D MacMillan, Haider M. Hassan, Karla C. Williams, Joseph Andrews, Ann F. Chambers, Carl O. Postenka, Matthew J. Cecchini, Alan B. Tuck, Bart Kolendowski, Muriel Brackstone, Hon S. Leong
Publikováno v:
Paediatrics Publications
The Journal of Pathology
The Journal of Pathology
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecular dynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955b99706156949f289d6264e3df9a25
https://doi.org/10.1002/path.5245
https://doi.org/10.1002/path.5245
Autor:
Karlee Searle, Yohan Kim, Karla C. Williams, Ann F. Chambers, Ashley V. Makela, Paula J. Foster, John A. Ronald, Alan B. Tuck, Sepideh Soukhtehzari, Mario A. Cepeda, Katie M. Parkins, Amanda M. Hamilton, Hon S. Leong, Sumreen Javed
Publikováno v:
Oncogene
Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebf1bd98128bba72b3a6e3e69be959
https://doi.org/10.1038/s41388-018-0667-4
https://doi.org/10.1038/s41388-018-0667-4
Publikováno v:
Nanoscale. 13(3)
Extracellular vesicles (EVs) are lipid membrane enclosed nano-sized structures released into the extracellular environment by all cell types. EV constituents include proteins, lipids and nucleic acids that reflect the cell from which they originated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6290bf1a052bcd319edb09d670704d2f
https://pubmed.ncbi.nlm.nih.gov/33449064
https://pubmed.ncbi.nlm.nih.gov/33449064